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Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan

التفاصيل البيبلوغرافية
العنوان: Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan
المؤلفون: Parker, Nadine, Vidal-Pineiro, Didac, French, Leon, Shin, Jean, Adams, Hieab HH, Brodaty, Henry, Cox, Simon R, Deary, Ian J, Fjell, Anders M, Frenzel, Stefan, Grabe, Hans, Hosten, Norbert, Ikram, Mohammad Arfan, Jiang, Jiyang, Knol, Maria J, Mazoyer, Bernard, Mishra, Aniket, Sachdev, Perminder S, Salum, Giovanni, Satizabal, Claudia L, Schmidt, Helena, Schmidt, Reinhold, Seshadri, Sudha, Schumann, Gunter, Völzke, Henry, Walhovd, Kristine B, Wen, Wei, Wittfeld, Katharina, Yang, Qiong, Debette, Stephanie, Pausova, Zdenka, Paus, Tomáš
المصدر: urn:ISSN:1047-3211 ; urn:ISSN:1460-2199 ; Cerebral Cortex, 30, 2, 575-586
بيانات النشر: Oxford University Press (OUP)
سنة النشر: 2019
المجموعة: UNSW Sydney (The University of New South Wales): UNSWorks
مصطلحات موضوعية: Aging, Brain Disorders, Neurosciences, 2 Aetiology, 1 Underpinning research, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Neurological, Adolescent, Adult, Aged, 80 and over, Cerebral Cortex, Child, Preschool, Female, Gene Expression, Humans, Male, Middle Aged, Receptors, Glucocorticoid, Mineralocorticoid, Young Adult, anzsrc-for: 1109 Neurosciences, anzsrc-for: 1701 Psychology, anzsrc-for: 1702 Cognitive Sciences
الوصف: Exposures to life stressors accumulate across the lifespan, with possible impact on brain health. Little is known, however, about the mechanisms mediating age-related changes in brain structure. We use a lifespan sample of participants (n = 21 251; 4-97 years) to investigate the relationship between the thickness of cerebral cortex and the expression of the glucocorticoid- and the mineralocorticoid-receptor genes (NR3C1 and NR3C2, respectively), obtained from the Allen Human Brain Atlas. In all participants, cortical thickness correlated negatively with the expression of both NR3C1 and NR3C2 across 34 cortical regions. The magnitude of this correlation varied across the lifespan. From childhood through early adulthood, the profile similarity (between NR3C1/NR3C2 expression and thickness) increased with age. Conversely, both profile similarities decreased with age in late life. These variations do not reflect age-related changes in NR3C1 and NR3C2 expression, as observed in 5 databases of gene expression in the human cerebral cortex (502 donors). Based on the co-expression of NR3C1 (and NR3C2) with genes specific to neural cell types, we determine the potential involvement of microglia, astrocytes, and CA1 pyramidal cells in mediating the relationship between corticosteroid exposure and cortical thickness. Therefore, corticosteroids may influence brain structure to a variable degree throughout life.
نوع الوثيقة: article in journal/newspaper
اللغة: unknown
العلاقة: http://purl.org/au-research/grants/nhmrc/APP1093083Test; http://purl.org/au-research/grants/nhmrc/APP1045325Test; http://hdl.handle.net/1959.4/unsworks_59599Test; https://doi.org/10.1093/cercor/bhz108Test
DOI: 10.1093/cercor/bhz108
الإتاحة: https://doi.org/10.1093/cercor/bhz108Test
http://hdl.handle.net/1959.4/unsworks_59599Test
حقوق: open access ; https://purl.org/coar/access_right/c_abf2Test ; CC BY ; https://creativecommons.org/licenses/by/4.0Test/
رقم الانضمام: edsbas.DDB56EE0
قاعدة البيانات: BASE
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