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Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype

التفاصيل البيبلوغرافية
العنوان: Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype
المؤلفون: Toubiana, Julie, Okada, Satoshi, Hiller, Julia, Oleastro, Matias, Gomez, Macarena Lagos, Becerra, Juan Carlos Aldave, Ouachãe chardin, Marie, Fouyssac, Fanny, Girisha, Katta Mohan, Etzioni, Amos, Van Montfrans, Joris, Camcioglu, Yildiz, Kerns, Leigh Ann, Belohradsky, Bernd, Blanche, Stephane, Bousfiha, Aziz, Rodriguez gallego, Carlos, Meyts, Isabelle, Kisand, Kai, Reichenbach, Janine, Renner, Ellen D. , Rosenzweig, Sergio, Grimbacher, Bodo, Van De Veerdonk, Frank L. , Traidl hoffmann, Claudia, Picard, Capucine, Marodi, Laszlo, Morio, Tomohiro, Kobayashi, Masao, Lilic, Desa, Milner, Joshua D. , Holland, Steven, Casanova, Jean Laurent, Puel, Anne, Cypowyj, Sophie, Caroline Thumerelle, Antoine Toulon, Jacinta Bustamante, Natalia Tahuil, Aicha Salhi, Sorina Boiu, Charu Chopra, Daniela Di Giovanni, Liliana Bezrodnik, JeannetteBoutros, Caroline Thomas, Gina Lacuesta, Sarah Jannier, Anne-Sophie Korganow, Catherine Paillard, David Boutboul, M ́elanie Bu ́e, Aude Marie-Cardine, Sophie Bayart, Mélanie Migaud, Laurence Weiss, Marina Karmochkine, Juan-Miguel Garcia-Martinez, Jean-Louis Stephan, Philippe Bensaid, Guy-Patrick Jeannoel, Torsten Witte, Ulrich Baumann, Thomas Harrer, Carmen Navarrete, Antony Terance Benjamin, Davide Firinu, Claudio Pignata, Paolo Picco, David Mendoza, Saul Oswaldo Lugo Reyes, Carlos Torres Lozano, MargaritaOrtega-Cisneros, Mariana Cortina, Mehrnaz Mesdaghi, MohammadNabavi, Teresa Español, Maia Teresa Martinez- Saavedra, Nima Rezaei, Samaneh Zoghi, Malgorzata Pac, Vincent Barlogis, Gabriel Revon-Rivire, Yishai Haimi-Cohen, Ronen Spiegel, Dan Miron, Jabir Bouchaib, Lizbeth Blancas-Galicia, Beata Toth, Barbara Drexel, Pierre Simon Roherlich, Olivier Lesens, Miriam Hoernes, Elizabeth Drewe, Mario Abinum, Julie Sawalle-Belohradsky, Gerhard Kindle, Mark Depner, Lili Milani, Tiit Nikopensius, Maido Remm, Ulvi Gerst Talas, Mark Tucker, Mary Willis, Stephanie Leonard, Hilaire Meuwissen, Ronald M. Ferdman, Mark Wallace, Mukesh M. Desai, Prasad Taur, Raffaele Badolato, Beata Soltesz, Christina Schnopp, Annette F. Jansson, Deniz Ayvaz, Nadejda Shabashova, Liudmyla Chernyshova, Anastasia Bondarenko, Despina Moshous, Benedicte Neven, Chahinez Boubidi, Fatima Ailal, Giuliana Giardino, Stefano Del Giacco, Marie-Elisabeth Bougnoux, Kohsuke Imai, Teppei Okawa, Yoko Mizoguchi, Yusuke Ozaki, Masato Takeuchi, Akira Hayakawa, Birgit Logering, Kristian Reich, Timo Buhl, Kilian Eyerich, Martin Schaller, Peter D. Arkwright, Andrew R. Gennery, Andrew J. Cant, Adilia Warris, Stefanie Henriet, Najla Mekki, Ridha Barbouche, Imen BenMustapha, Christine Bodemer, Michel Polak, EmmanuelGrimprel, Pierre-R ́egis Burgel, Alain Fischer, Olivier Hermine, Marianne Debr ́e, Dilara Kocacyk, Fatima Dhalla, Smita Y. Patel, Leen Moens, Filomeen Haerynck, Melissa Dullaers, Levi Hoste, Ozden Sanal, Sara Sebnem Kilic, Joachim Roesler, Fanny Lanternier, Olivier Lortholary, Claire Fieschi, Joseph A. Church, Chaim Roifman, Araya Yuenyongviwat, Part Peterson, Stéphanie Boisson-Dupuis, Laurent Abel, Beatriz E. Marciano, Mihai G. Netea
المساهمون: Toubiana, Okada, Julie, Hiller, Satoshi, Oleastro, Julia, Gomez, Matia, Becerra, Macarena Lago, Ouachãe chardin, Juan Carlos Aldave, Fouyssac, Marie, Girisha, Fanny, Etzioni, Katta Mohan, Van Montfrans, Amo, Camcioglu, Jori, Kerns, Yildiz, Belohradsky, Leigh Ann, Blanche, Bernd, Bousfiha, Stephane, Rodriguez gallego, Aziz, Meyts, Carlo, Kisand, Isabelle, Reichenbach, Kai, Renner, Janine, Rosenzweig, Ellen D., Grimbacher, Sergio, Van De Veerdonk, Bodo, Traidl hoffmann, Frank L., Picard, Claudia, Marodi, Capucine, Morio, Laszlo, Kobayashi, Tomohiro, Lilic, Masao, Milner, Desa, Holland, Joshua D., Casanova, Steven, Puel, Jean Laurent, Cypowyj, Anne, Sophie, Thumerelle, Caroline, Toulon, Antoine, Bustamante, Jacinta, Tahuil, Natalia, Salhi, Aicha, Boiu, Sorina, Chopra, Charu, Di Giovanni, Daniela, Bezrodnik, Liliana, Jeannetteboutros, Thomas, Caroline, Lacuesta, Gina, Jannier, Sarah, Korganow, Anne-Sophie, Paillard, Catherine, Boutboul, David, Bu ́e, M ́elanie, Marie-Cardine, Aude, Bayart, Sophie, Migaud, Mélanie, Weiss, Laurence, Karmochkine, Marina, Garcia-Martinez, Juan-Miguel, Stephan, Jean-Loui, Bensaid, Philippe, Jeannoel, Guy-Patrick, Witte, Torsten, Baumann, Ulrich, Harrer, Thoma, Navarrete, Carmen, Terance Benjamin, Antony, Firinu, Davide, Pignata, Claudio, Picco, Paolo, Mendoza, David, Oswaldo Lugo Reyes, Saul, Torres Lozano, Carlo, MargaritaOrtega-Cisneros, Cortina, Mariana, Mesdaghi, Mehrnaz, Mohammadnabavi, Español, Teresa, Teresa Martinez- Saavedra, Maia, Rezaei, Nima, Zoghi, Samaneh, Pac, Malgorzata, Barlogis, Vincent, Revon-Rivire, Gabriel, Haimi-Cohen, Yishai, Spiegel, Ronen, Miron, Dan, Bouchaib, Jabir, Blancas-Galicia, Lizbeth, Toth, Beata, Drexel, Barbara, Simon Roherlich, Pierre, Lesens, Olivier, Hoernes, Miriam, Drewe, Elizabeth, Abinum, Mario, Sawalle-Belohradsky, Julie, Kindle, Gerhard, Depner, Mark, Milani, Lili
سنة النشر: 2016
المجموعة: Università degli Studi di Cagliari: UNICA IRIS
مصطلحات موضوعية: Adolescent, Adult, Aged, Candidiasis, Chronic mucocutaneou, Child, preschool, Cohort studie, Female, Genetic predisposition to disease, Heterozygote, Human, Infant, Male, Middle aged, Phenotype, STAT1 transcription factor, Young adult, Genetic association studie, Mutation, Biochemistry, Immunology, Hematology, Cell biology
الوصف: Since their discovery in patients with autosomal dominant (AD) chronic mucocutaneous candidiasis (CMC) in 2011, heterozygous STAT1 gain-of-function (GOF) mutations have increasingly been identified worldwide. The clinical spectrum associated with them needed to be delineated. We enrolled 274 patients from 167 kindreds originating from 40 countries from 5 continents. Demographic data, clinical features, immunological parameters, treatment, and outcome were recorded. The median age of the 274 patients was 22 years (range, 1-71 years); 98% of them had CMC, with a median age at onset of 1 year (range, 0-24 years). Patients often displayed bacterial (74%) infections, mostly because of Staphylococcus aureus (36%), including the respiratory tract and the skin in 47% and 28% of patients, respectively, and viral (38%) infections, mostly because of Herpesviridae (83%) and affecting the skin in 32% of patients. Invasive fungal infections (10%), mostly caused by Candida spp. (29%), and mycobacterial disease (6%) caused by Mycobacterium tuberculosis, environmental mycobacteria, or Bacille Calmette-Guérin vaccines were less common. Many patients had autoimmune manifestations (37%), including hypothyroidism (22%), type 1 diabetes (4%), blood cytopenia (4%), and systemic lupus erythematosus (2%). Invasive infections (25%), cerebral aneurysms (6%), and cancers (6%) were the strongest predictors of poor outcome. CMC persisted in 39% of the 202 patients receiving prolonged antifungal treatment. Circulating interleukin-17A-producing T-cell count was low for most (82%) but not all of the patients tested. STAT1 GOF mutations underlie AD CMC, as well as an unexpectedly wide range of other clinical features, including not only a variety of infectious and autoimmune diseases, but also cerebral aneurysms and carcinomas that confer a poor prognosis.
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27114460; info:eu-repo/semantics/altIdentifier/wos/WOS:000378337700009; volume:127; issue:25; firstpage:3154; lastpage:3164; numberofpages:11; journal:BLOOD; http://hdl.handle.net/11584/225549Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84977482520; http://www.bloodjournal.org/content/bloodjournal/127/25/3154.full.pdfTest
DOI: 10.1182/blood-2015-11-679902
الإتاحة: https://doi.org/10.1182/blood-2015-11-679902Test
http://hdl.handle.net/11584/225549Test
http://www.bloodjournal.org/content/bloodjournal/127/25/3154.full.pdfTest
حقوق: info:eu-repo/semantics/closedAccess
رقم الانضمام: edsbas.D76642B4
قاعدة البيانات: BASE
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Cant</searchLink><br /><searchLink fieldCode="AR" term="%22Adilia+Warris%22">Adilia Warris</searchLink><br /><searchLink fieldCode="AR" term="%22Stefanie+Henriet%22">Stefanie Henriet</searchLink><br /><searchLink fieldCode="AR" term="%22Najla+Mekki%22">Najla Mekki</searchLink><br /><searchLink fieldCode="AR" term="%22Ridha+Barbouche%22">Ridha Barbouche</searchLink><br /><searchLink fieldCode="AR" term="%22Imen+BenMustapha%22">Imen BenMustapha</searchLink><br /><searchLink fieldCode="AR" term="%22Christine+Bodemer%22">Christine Bodemer</searchLink><br /><searchLink fieldCode="AR" term="%22Michel+Polak%22">Michel Polak</searchLink><br /><searchLink fieldCode="AR" term="%22EmmanuelGrimprel%22">EmmanuelGrimprel</searchLink><br /><searchLink fieldCode="AR" term="%22Pierre-R+́egis+Burgel%22">Pierre-R ́egis Burgel</searchLink><br /><searchLink fieldCode="AR" term="%22Alain+Fischer%22">Alain Fischer</searchLink><br /><searchLink fieldCode="AR" term="%22Olivier+Hermine%22">Olivier Hermine</searchLink><br /><searchLink fieldCode="AR" term="%22Marianne+Debr+́e%22">Marianne Debr ́e</searchLink><br /><searchLink fieldCode="AR" term="%22Dilara+Kocacyk%22">Dilara Kocacyk</searchLink><br /><searchLink fieldCode="AR" term="%22Fatima+Dhalla%22">Fatima Dhalla</searchLink><br /><searchLink fieldCode="AR" term="%22Smita+Y%2E+Patel%22">Smita Y. Patel</searchLink><br /><searchLink fieldCode="AR" term="%22Leen+Moens%22">Leen Moens</searchLink><br /><searchLink fieldCode="AR" term="%22Filomeen+Haerynck%22">Filomeen Haerynck</searchLink><br /><searchLink fieldCode="AR" term="%22Melissa+Dullaers%22">Melissa Dullaers</searchLink><br /><searchLink fieldCode="AR" term="%22Levi+Hoste%22">Levi Hoste</searchLink><br /><searchLink fieldCode="AR" term="%22Ozden+Sanal%22">Ozden Sanal</searchLink><br /><searchLink fieldCode="AR" term="%22Sara+Sebnem+Kilic%22">Sara Sebnem Kilic</searchLink><br /><searchLink fieldCode="AR" term="%22Joachim+Roesler%22">Joachim Roesler</searchLink><br /><searchLink fieldCode="AR" term="%22Fanny+Lanternier%22">Fanny Lanternier</searchLink><br /><searchLink fieldCode="AR" term="%22Olivier+Lortholary%22">Olivier Lortholary</searchLink><br /><searchLink fieldCode="AR" term="%22Claire+Fieschi%22">Claire Fieschi</searchLink><br /><searchLink fieldCode="AR" term="%22Joseph+A%2E+Church%22">Joseph A. Church</searchLink><br /><searchLink fieldCode="AR" term="%22Chaim+Roifman%22">Chaim Roifman</searchLink><br /><searchLink fieldCode="AR" term="%22Araya+Yuenyongviwat%22">Araya Yuenyongviwat</searchLink><br /><searchLink fieldCode="AR" term="%22Part+Peterson%22">Part Peterson</searchLink><br /><searchLink fieldCode="AR" term="%22Stéphanie+Boisson-Dupuis%22">Stéphanie Boisson-Dupuis</searchLink><br /><searchLink fieldCode="AR" term="%22Laurent+Abel%22">Laurent Abel</searchLink><br /><searchLink fieldCode="AR" term="%22Beatriz+E%2E+Marciano%22">Beatriz E. Marciano</searchLink><br /><searchLink fieldCode="AR" term="%22Mihai+G%2E+Netea%22">Mihai G. Netea</searchLink> )
Array ( [Name] => Author [Label] => Contributors [Group] => Au [Data] => Toubiana<br />Okada, Julie<br />Hiller, Satoshi<br />Oleastro, Julia<br />Gomez, Matia<br />Becerra, Macarena Lago<br />Ouachãe chardin, Juan Carlos Aldave<br />Fouyssac, Marie<br />Girisha, Fanny<br />Etzioni, Katta Mohan<br />Van Montfrans, Amo<br />Camcioglu, Jori<br />Kerns, Yildiz<br />Belohradsky, Leigh Ann<br />Blanche, Bernd<br />Bousfiha, Stephane<br />Rodriguez gallego, Aziz<br />Meyts, Carlo<br />Kisand, Isabelle<br />Reichenbach, Kai<br />Renner, Janine<br />Rosenzweig, Ellen D.<br />Grimbacher, Sergio<br />Van De Veerdonk, Bodo<br />Traidl hoffmann, Frank L.<br />Picard, Claudia<br />Marodi, Capucine<br />Morio, Laszlo<br />Kobayashi, Tomohiro<br />Lilic, Masao<br />Milner, Desa<br />Holland, Joshua D.<br />Casanova, Steven<br />Puel, Jean Laurent<br />Cypowyj, Anne<br />Sophie<br />Thumerelle, Caroline<br />Toulon, Antoine<br />Bustamante, Jacinta<br />Tahuil, Natalia<br />Salhi, Aicha<br />Boiu, Sorina<br />Chopra, Charu<br />Di Giovanni, Daniela<br />Bezrodnik, Liliana<br />Jeannetteboutros<br />Thomas, Caroline<br />Lacuesta, Gina<br />Jannier, Sarah<br />Korganow, Anne-Sophie<br />Paillard, Catherine<br />Boutboul, David<br />Bu ́e, M ́elanie<br />Marie-Cardine, Aude<br />Bayart, Sophie<br />Migaud, Mélanie<br />Weiss, Laurence<br />Karmochkine, Marina<br />Garcia-Martinez, Juan-Miguel<br />Stephan, Jean-Loui<br />Bensaid, Philippe<br />Jeannoel, Guy-Patrick<br />Witte, Torsten<br />Baumann, Ulrich<br />Harrer, Thoma<br />Navarrete, Carmen<br />Terance Benjamin, Antony<br />Firinu, Davide<br />Pignata, Claudio<br />Picco, Paolo<br />Mendoza, David<br />Oswaldo Lugo Reyes, Saul<br />Torres Lozano, Carlo<br />MargaritaOrtega-Cisneros<br />Cortina, Mariana<br />Mesdaghi, Mehrnaz<br />Mohammadnabavi<br />Español, Teresa<br />Teresa Martinez- Saavedra, Maia<br />Rezaei, Nima<br />Zoghi, Samaneh<br />Pac, Malgorzata<br />Barlogis, Vincent<br />Revon-Rivire, Gabriel<br />Haimi-Cohen, Yishai<br />Spiegel, Ronen<br />Miron, Dan<br />Bouchaib, Jabir<br />Blancas-Galicia, Lizbeth<br />Toth, Beata<br />Drexel, Barbara<br />Simon Roherlich, Pierre<br />Lesens, Olivier<br />Hoernes, Miriam<br />Drewe, Elizabeth<br />Abinum, Mario<br />Sawalle-Belohradsky, Julie<br />Kindle, Gerhard<br />Depner, Mark<br />Milani, Lili )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2016 )
Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => Università degli Studi di Cagliari: UNICA IRIS )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Adolescent%22">Adolescent</searchLink><br /><searchLink fieldCode="DE" term="%22Adult%22">Adult</searchLink><br /><searchLink fieldCode="DE" term="%22Aged%22">Aged</searchLink><br /><searchLink fieldCode="DE" term="%22Candidiasis%22">Candidiasis</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+mucocutaneou%22">Chronic mucocutaneou</searchLink><br /><searchLink fieldCode="DE" term="%22Child%22">Child</searchLink><br /><searchLink fieldCode="DE" term="%22preschool%22">preschool</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+studie%22">Cohort studie</searchLink><br /><searchLink fieldCode="DE" term="%22Female%22">Female</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+predisposition+to+disease%22">Genetic predisposition to disease</searchLink><br /><searchLink fieldCode="DE" term="%22Heterozygote%22">Heterozygote</searchLink><br /><searchLink fieldCode="DE" term="%22Human%22">Human</searchLink><br /><searchLink fieldCode="DE" term="%22Infant%22">Infant</searchLink><br /><searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%22Middle+aged%22">Middle aged</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotype%22">Phenotype</searchLink><br /><searchLink fieldCode="DE" term="%22STAT1+transcription+factor%22">STAT1 transcription factor</searchLink><br /><searchLink fieldCode="DE" term="%22Young+adult%22">Young adult</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+association+studie%22">Genetic association studie</searchLink><br /><searchLink fieldCode="DE" term="%22Mutation%22">Mutation</searchLink><br /><searchLink fieldCode="DE" term="%22Biochemistry%22">Biochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Immunology%22">Immunology</searchLink><br /><searchLink fieldCode="DE" term="%22Hematology%22">Hematology</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+biology%22">Cell biology</searchLink> )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Since their discovery in patients with autosomal dominant (AD) chronic mucocutaneous candidiasis (CMC) in 2011, heterozygous STAT1 gain-of-function (GOF) mutations have increasingly been identified worldwide. The clinical spectrum associated with them needed to be delineated. We enrolled 274 patients from 167 kindreds originating from 40 countries from 5 continents. Demographic data, clinical features, immunological parameters, treatment, and outcome were recorded. The median age of the 274 patients was 22 years (range, 1-71 years); 98% of them had CMC, with a median age at onset of 1 year (range, 0-24 years). Patients often displayed bacterial (74%) infections, mostly because of Staphylococcus aureus (36%), including the respiratory tract and the skin in 47% and 28% of patients, respectively, and viral (38%) infections, mostly because of Herpesviridae (83%) and affecting the skin in 32% of patients. Invasive fungal infections (10%), mostly caused by Candida spp. (29%), and mycobacterial disease (6%) caused by Mycobacterium tuberculosis, environmental mycobacteria, or Bacille Calmette-Guérin vaccines were less common. Many patients had autoimmune manifestations (37%), including hypothyroidism (22%), type 1 diabetes (4%), blood cytopenia (4%), and systemic lupus erythematosus (2%). Invasive infections (25%), cerebral aneurysms (6%), and cancers (6%) were the strongest predictors of poor outcome. CMC persisted in 39% of the 202 patients receiving prolonged antifungal treatment. Circulating interleukin-17A-producing T-cell count was low for most (82%) but not all of the patients tested. STAT1 GOF mutations underlie AD CMC, as well as an unexpectedly wide range of other clinical features, including not only a variety of infectious and autoimmune diseases, but also cerebral aneurysms and carcinomas that confer a poor prognosis. )
Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper )
Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English )
Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => info:eu-repo/semantics/altIdentifier/pmid/27114460; info:eu-repo/semantics/altIdentifier/wos/WOS:000378337700009; volume:127; issue:25; firstpage:3154; lastpage:3164; numberofpages:11; journal:BLOOD; http://hdl.handle.net/11584/225549; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84977482520; http://www.bloodjournal.org/content/bloodjournal/127/25/3154.full.pdf )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1182/blood-2015-11-679902 )
Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://doi.org/10.1182/blood-2015-11-679902<br />http://hdl.handle.net/11584/225549<br />http://www.bloodjournal.org/content/bloodjournal/127/25/3154.full.pdf )
Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => info:eu-repo/semantics/closedAccess )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.D76642B4 )
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[51] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => David Boutboul ) ) ) [52] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => M ́elanie Bu ́e ) ) ) [53] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Aude Marie-Cardine ) ) ) [54] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Sophie Bayart ) ) ) [55] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Mélanie Migaud ) ) ) [56] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Laurence Weiss ) ) ) [57] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Marina Karmochkine ) ) ) [58] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Juan-Miguel Garcia-Martinez ) ) ) [59] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Jean-Louis Stephan ) ) ) [60] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Philippe Bensaid ) ) ) [61] => Array ( 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Array ( [NameFull] => Saul Oswaldo Lugo Reyes ) ) ) [72] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Carlos Torres Lozano ) ) ) [73] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => MargaritaOrtega-Cisneros ) ) ) [74] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Mariana Cortina ) ) ) [75] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Mehrnaz Mesdaghi ) ) ) [76] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => MohammadNabavi ) ) ) [77] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Teresa Español ) ) ) [78] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Maia Teresa Martinez- Saavedra ) ) ) [79] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Nima Rezaei ) ) ) [80] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Samaneh Zoghi ) ) ) [81] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Malgorzata Pac ) ) ) [82] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Vincent Barlogis ) ) ) [83] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Gabriel Revon-Rivire ) ) ) [84] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Yishai Haimi-Cohen ) ) ) [85] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Ronen Spiegel ) ) ) [86] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Dan Miron ) ) ) [87] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Jabir Bouchaib ) ) ) [88] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lizbeth Blancas-Galicia ) ) ) [89] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Beata Toth ) ) ) [90] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Barbara Drexel ) ) ) [91] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Pierre Simon Roherlich ) 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