دورية أكاديمية
Unique composite hematolymphoid tumor consisting of a pro-T lymphoblastic lymphoma and an indeterminate dendritic cell tumor: evidence for divergent common progenitor cell differentiation
| العنوان: | Unique composite hematolymphoid tumor consisting of a pro-T lymphoblastic lymphoma and an indeterminate dendritic cell tumor: evidence for divergent common progenitor cell differentiation |
|---|---|
| المؤلفون: | Buser, Lorenz, Bihl, Michel, Rufle, Alexander, Mickys, Ugnius, Tavorienė, Ilma, Griškevičius, Laimonas, Tzankov, Alexandar |
| المصدر: | Pathobiology: exploring the basis of disease, Basel : S. Karger AG, 2014, vol. 81, no. 4, p. 199-205 ; ISSN 1015-2008 |
| سنة النشر: | 2014 |
| المجموعة: | LAEI VL (Lithuanian Institute of Agrarian Economics Virtual Library) / LAEI VB (Lietuvos agrarinės ekonomikos institutasvirtualią biblioteką) |
| مصطلحات موضوعية: | Lymphoblastic lymphoma, Indeterminate dendritic cell tumor, Transdifferentiation, Gene rearrangement, NRAS gene, PU.1 |
| الوصف: | Until recently, hematopoietic neoplasms were considered monoclonal proliferations belonging to one cell lineage. In the last years, evidence for transdifferentiation from one cell lineage to another or divergent common progenitor cell differentiation has accumulated, mainly based on composite hematolymphoid tumors, sharing common genetic abnormalities. We report the case of a 59-year-old woman with a composite pro-T lymphoblastic lymphoma (LBL) and indeterminate dendritic cell tumor infiltrating the lymph nodes, bone marrow and stomach. Genetic analyses revealed that both cell populations bore +21, while a G13D mutation of the NRAS gene and monosomy 18 were detected only in the pro-T LBL. The synchronous appearance of two distinct uncommon hematolymphoid tumors in the same patient, recurrent at three different anatomic locations, with an identifiable common genetic denominator, namely +21, but also with unique genetic anomalies in the pro-T LBL raises the hypothesis of a divergent common progenitor cell differentiation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://vu.lvb.lt/VU:ELABAPDB6150731&prefLang=en_USTest |
| الإتاحة: | https://doi.org/10.1159/000365396Test http://vu.lvb.lt/VU:ELABAPDB6150731&prefLang=en_USTest |
| رقم الانضمام: | edsbas.D492C5D |
| قاعدة البيانات: | BASE |
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