دورية أكاديمية
ORIGINAL ARTICLE DOI:10.3904/kjim.2010.25.1.77 Application of Cystatin C Reduction Ratio to High-Flux Hemodialysis as an Alternative Indicator of the Clearance of Middle Molecules
| العنوان: | ORIGINAL ARTICLE DOI:10.3904/kjim.2010.25.1.77 Application of Cystatin C Reduction Ratio to High-Flux Hemodialysis as an Alternative Indicator of the Clearance of Middle Molecules |
|---|---|
| المؤلفون: | Joon-sung Park, Gheun-ho Kim, Chong Myung Kang, Chang Hwa Lee |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/34/44/Korean_J_Intern_Med_2010_Mar_26_25(1)_77-81.tar.gz |
| المجموعة: | CiteSeerX |
| مصطلحات موضوعية: | Dialysis, beta 2-Microglobulin, Cystatin C |
| الوصف: | Background/Aims: Although high-flux (HF) dialyzers with enhanced membrane permeability are widely used in current hemodialysis (HD) practice, urea kinetic modeling is still being applied to indicate the adequacy of both low-flux (LF) and HF HD. In comparison with urea (molecular weight, 60 Da) and β2-microglobulin (β2MG, 12 kDa), cystatin C (CyC, 13 kDa) is a larger molecule that has attractive features as a marker for assessing solute clearance. We postulated that CyC might be an alternative for indicating the clearance of middle molecules (MMs), especially with HF HD. Methods: Eighty-nine patients were divided into LF and HF groups. Using single pool urea kinetic modeling, the urea reduction ratio (URR) and equilibrated Kt/Vurea (eKt / Vurea) were calculated. The serum CyC concentrations were measured using particle-enhanced immunonephelometry. As indices of the middle molecular clearance, the reduction ratios of β2MG and CyC were calculated. Results: The β2MG reduction ratio (β2MGRR) and CyC reduction ratio (CyCRR) were higher in the HF group compared to the LF group. However, the URR and eKt/Vurea did not differ between the two groups. The CyCRR was significantly correlated with the eKt/Vurea and β2MGRR (r = 0.47 and 0.69, respectively, both p < 0.0001). Conclusions: Compared to the LF dialyzer, the HF dialyzer removed CyC and β2MG more efficiently. Unlike the β2MGRR, the CyCRR was correlated with the eKt/Vurea and β2MGRR. This study suggests a role for the CyCRR as an alternative indicator of the removal of MMs. (Korean J Intern Med 2010;25:77-81) |
| نوع الوثيقة: | text |
| وصف الملف: | application/zip |
| اللغة: | English |
| العلاقة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.356.7706Test |
| حقوق: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.D451A8B6 |
| قاعدة البيانات: | BASE |
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