دورية أكاديمية
Differential Regulation of Protein Subdomain Activity with Caged Bivalent Ligands
| العنوان: | Differential Regulation of Protein Subdomain Activity with Caged Bivalent Ligands |
|---|---|
| المؤلفون: | Mayer, Günter, Müller, Jens, Mack, Timo, Freitag, Daniel F., Höver, Thomas, Pötzsch, Bernd, Heckel, Alexander |
| المصدر: | ChemBioChem ; volume 10, issue 4, page 654-657 ; ISSN 1439-4227 1439-7633 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2009 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Subtle change : Spatiotemporal modulation of individual protein subdomains with light as the trigger signal becomes possible by using bivalent aptamers and introducing photolabile “caging groups” to switch individual aptamer modules ON or OFF differentially. To the best of our knowledge, this is the first study to show that it is possible to modulate individual domain activity in aptamers, and thus also domain activity in proteins, with light. magnified image |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/cbic.200800814 |
| الإتاحة: | https://doi.org/10.1002/cbic.200800814Test |
| حقوق: | http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: | edsbas.D1B16691 |
| قاعدة البيانات: | BASE |
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