دورية أكاديمية
The emerging role of MicroRNA-182 in tumorigenesis; a promising therapeutic target
| العنوان: | The emerging role of MicroRNA-182 in tumorigenesis; a promising therapeutic target |
|---|---|
| المؤلفون: | Sameti, Pouriya, Tohidast, Maryam, Amini, Mohammad, Bahojb Mahdavi, Seyedeh Zahra, Najafi, Souzan, Mokhtarzadeh, Ahad |
| المصدر: | Cancer Cell International ; volume 23, issue 1 ; ISSN 1475-2867 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Cancer Research, Genetics, Oncology |
| الوصف: | A wide range of studies have indicated that microRNAs (miRNAs), a type of small single-stranded regulatory RNAs, are dysregulated in a different variety of human cancers. Therefore, they are expected to play important roles in tumorigenesis by functioning as oncogenic (oncomiRs) or tumor-suppressive miRNAs. Subsequently, their potential as diagnostic and therapeutic targets for malignancies has attracted attention in recent years. In particular, studies have revealed the aberrant expression of miR-182 through tumorigenesis and its important roles in various aspects of malignancies, including proliferation, metastasis, and chemoresistance. Accumulating reports have illustrated that miR-182, as a dual-role regulator, directly or indirectly regulates the expression of a wide range of genes and modulates the activity of various signaling pathways involved in tumor progression, such as JAK / STAT3, Wnt / β-catenin, TGF-β, and P13K / AKT. Therefore, considering the high therapeutic and diagnostic potential of miR-182, this review aims to point out the effects of miR-182 dysregulation on the signaling pathways involved in tumorigenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12935-023-02972-0 |
| DOI: | 10.1186/s12935-023-02972-0.pdf |
| DOI: | 10.1186/s12935-023-02972-0/fulltext.html |
| الإتاحة: | https://doi.org/10.1186/s12935-023-02972-0Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.C5AC181A |
| قاعدة البيانات: | BASE |
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