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Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension

التفاصيل البيبلوغرافية
العنوان: Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension
المؤلفون: DEROSA, GIUSEPPE, D'ANGELO, ANGELA, Ciccarelli L, Piccinni MN, Pricolo F, Salvadeo S, Montagna L, Gravina A, Ferrari I, Galli S, Paniga S, Tinelli C, Cicero AFG
المساهمون: Derosa, Giuseppe, D'Angelo, Angela, Ciccarelli, L, Piccinni, Mn, Pricolo, F, Salvadeo, S, Montagna, L, Gravina, A, Ferrari, I, Galli, S, Paniga, S, Tinelli, C, Cicero, Afg
سنة النشر: 2006
المجموعة: IRIS UNIPV (Università degli studi di Pavia)
مصطلحات موضوعية: Adult, Blood Glucose, analysis, Blood Pressure Determination, Case-Control Studies, Female, Fibrinolysis, Humans, Hypertension, blood/enzymology, Inflammation, Lipid, blood, Male, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Middle Aged, Plasminogen Activator Inhibitor 1, Tissue Inhibitor of Metalloproteinase-1
الوصف: There are conflicting data in the literature regarding the expression pattern of the vascular matrix metalloproteinase (MMP) system and their inhibitors (TIMPs) in human hypertension. The authors hypothesized that MMP-2, MMP-9, and TIMP-1 would be abnormal in hypertension, reflecting alterations in extracellular matrix (ECM) turnover. The authors measured plasma levels and activities of MMP-2, MMP-9, and TIMP-1 in 44 hypertensive patients and 44 controls. MMP-2 levels and activity were significantly higher in hypertensive group (p < .0001). Significant increase was also observed for MMP-9 level and activity (p < .0001) and for TIMP-1 (p < .0001) in hypertensive patients. Plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal ECM metabolism.
نوع الوثيقة: article in journal/newspaper
وصف الملف: STAMPA
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/16840178; info:eu-repo/semantics/altIdentifier/wos/000239391800007; volume:13; firstpage:227; lastpage:231; numberofpages:5; journal:ENDOTHELIUM; http://hdl.handle.net/11571/379043Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33746380241; http://dx.doi.org/10.1080/10623320600780942Test
DOI: 10.1080/10623320600780942
الإتاحة: https://doi.org/10.1080/10623320600780942Test
http://hdl.handle.net/11571/379043Test
رقم الانضمام: edsbas.C571F64F
قاعدة البيانات: BASE
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