دورية أكاديمية
Prevalence of Clostridioides difficile in Canine Feces and Its Association with Intestinal Dysbiosis
| العنوان: | Prevalence of Clostridioides difficile in Canine Feces and Its Association with Intestinal Dysbiosis |
|---|---|
| المؤلفون: | Werner M., Ishii P. E., Pilla R., Lidbury J. A., Steiner J. M., Busch-Hahn K., Unterer S., Suchodolski J. S. |
| المساهمون: | M. Werner, P.E. Ishii, R. Pilla, J.A. Lidbury, J.M. Steiner, K. Busch-Hahn, S. Unterer, J.S. Suchodolski |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Clostridium, dog, enteropathogen, microbiome, microbiota, Settore VET/05 - Malattie Infettive degli Animali Domestici |
| الوصف: | The role of Clostridioides (C.) difficile as an enteropathogen in dogs is controversial. In humans, intestinal bile acid-dysmetabolism is associated with C. difficile prevalence. The relationship between fecal qPCR-based dysbiosis index (DI) and especially the abundance of bile acid-converting Clostridium hiranonis with the presence of C. difficile in dogs was explored across the following 4 cohorts: 358 fecal samples submitted for routine diagnostic work-up, 33 dogs with chronic enteropathy, 14 dogs with acute diarrhea, and 116 healthy dogs. Dogs that tested positive for C. difficile had significantly higher DI (median, 4.4 (range from 0.4 to 8.6)) and lower C. hiranonis (median, 0.1 (range from 0.0 to 7.5) logDNA/g) than dogs that tested negative for C. difficile (median DI, −1 (range from −7.2 to 8.9); median C. hiranonis abundance, 6.2 (range from 0.1 to 7.5) logDNA/g; p < 0.0001, respectively). In 33 dogs with CE and 14 dogs with acute diarrhea, the treatment response did not differ between C. difficile-positive and -negative dogs. In the group of clinically healthy dogs, 9/116 tested positive for C. difficile, and 6/9 of these had also an abnormal DI. In conclusion, C. difficile is strongly linked to intestinal dysbiosis and lower C. hiranonis levels in dogs, but its presence does not necessitate targeted treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37570250; info:eu-repo/semantics/altIdentifier/wos/WOS:001045281300001; volume:13; issue:15; firstpage:1; lastpage:13; numberofpages:13; journal:ANIMALS; https://hdl.handle.net/2434/1044437Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85167622792 |
| DOI: | 10.3390/ani13152441 |
| الإتاحة: | https://doi.org/10.3390/ani13152441Test https://hdl.handle.net/2434/1044437Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C3A8040C |
| قاعدة البيانات: | BASE |
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