دورية أكاديمية
Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy
| العنوان: | Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy |
|---|---|
| المؤلفون: | Hoffmann, Emily, Gerwing, Mirjam, Kraehling, Tobias, Hansen, Uwe, Kronenberg, Katharina, Masthoff, Max, Geyer, Christiane, Hoeltke, Carsten, Wachsmuth, Lydia, Schinner, Regina, Hoerr, Verena, Heindel, Walter, Karst, Uwe, Eisenblätter, Michel, Maus, Bastian, Helfen, Anne, Faber, Cornelius, Wildgruber, Moritz |
| بيانات النشر: | BMC |
| سنة النشر: | 2023 |
| المجموعة: | PUB - Publications at Bielefeld University |
| مصطلحات موضوعية: | Tumor vasculature, Magnetic resonance imaging, Targeted therapy, Tumor, microenvironment, Immune checkpoint inhibition, Sorafenib |
| الوصف: | Hoffmann E, Gerwing M, Kraehling T, et al. Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy. Breast Cancer Research . 2023;25(1): 56. ; BackgroundResponse assessment of targeted cancer therapies is becoming increasingly challenging, as it is not adequately assessable with conventional morphological and volumetric analyses of tumor lesions. The tumor microenvironment is particularly constituted by tumor vasculature which is altered by various targeted therapies. The aim of this study was to noninvasively assess changes in tumor perfusion and vessel permeability after targeted therapy in murine models of breast cancer with divergent degrees of malignancy.MethodsLow malignant 67NR or highly malignant 4T1 tumor-bearing mice were treated with either the multi-kinase inhibitor sorafenib or immune checkpoint inhibitors (ICI, combination of anti-PD1 and anti-CTLA4). Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with i.v. injection of albumin-binding gadofosveset was conducted on a 9.4 T small animal MRI. Ex vivo validation of MRI results was achieved by transmission electron microscopy, immunohistochemistry and laser ablation-inductively coupled plasma-mass spectrometry.ResultsTherapy-induced changes in tumor vasculature differed between low and highly malignant tumors. Sorafenib treatment led to decreased tumor perfusion and endothelial permeability in low malignant 67NR tumors. In contrast, highly malignant 4T1 tumors demonstrated characteristics of a transient window of vascular normalization with an increase in tumor perfusion and permeability early after therapy initiation, followed by decreased perfusion and permeability parameters. In the low malignant 67NR model, ICI treatment also mediated vessel-stabilizing effects with decreased tumor perfusion and permeability, while ICI-treated 4T1 tumors exhibited increasing tumor perfusion with excessive vascular leakage.ConclusionDCE-MRI enables noninvasive assessment of early changes in ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/issn/1465-5411; info:eu-repo/semantics/altIdentifier/issn/1465-542X; info:eu-repo/semantics/altIdentifier/wos/000992436000001; info:eu-repo/semantics/altIdentifier/pmid/37221619; https://pub.uni-bielefeld.de/record/2979724Test |
| الإتاحة: | https://doi.org/10.1186/s13058-023-01658-9Test https://pub.uni-bielefeld.de/record/2979724Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.BF7E5B5A |
| قاعدة البيانات: | BASE |
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Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy. Breast Cancer Research . 2023;25(1): 56. ; BackgroundResponse assessment of targeted cancer therapies is becoming increasingly challenging, as it is not adequately assessable with conventional morphological and volumetric analyses of tumor lesions. The tumor microenvironment is particularly constituted by tumor vasculature which is altered by various targeted therapies. The aim of this study was to noninvasively assess changes in tumor perfusion and vessel permeability after targeted therapy in murine models of breast cancer with divergent degrees of malignancy.MethodsLow malignant 67NR or highly malignant 4T1 tumor-bearing mice were treated with either the multi-kinase inhibitor sorafenib or immune checkpoint inhibitors (ICI, combination of anti-PD1 and anti-CTLA4). 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