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Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort.

التفاصيل البيبلوغرافية
العنوان: Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort.
المؤلفون: Bravis, Vassiliki, Kaur, Akaal, Walkey, Helen C, Godsland, Ian F, Misra, Shivani, Bingley, Polly J, Williams, Alistair JK, Dunger, David B, Dayan, Colin M, Peakman, Mark, Oliver, Nick S, Johnston, Desmond G, ADDRESS-2 Management Committee, Patient Advocate Group and Investigators
بيانات النشر: BMJ
//dx.doi.org/10.1136/bmjopen-2017-020904
BMJ Open
سنة النشر: 2018
المجموعة: Apollo - University of Cambridge Repository
مصطلحات موضوعية: epidemiology, general diabetes, immunology, paediatric endocrinology, Adolescent, Adult, Autoantibodies, Child, Preschool, Cohort Studies, Diabetes Mellitus, Type 1, England, Female, Humans, Islets of Langerhans, Male, Wales
الوصف: OBJECTIVES: To describe the characteristics of children and adults with incident type 1 diabetes in contemporary, multiethnic UK, focusing on differences between the islet autoantibody negative and positive. DESIGN: Observational cohort study. SETTING: 146 mainly secondary care centres across England and Wales. PARTICIPANTS: 3312 people aged ≥5 years were recruited within 6 months of a clinical diagnosis of type 1 diabetes via the National Institute for Health Research Clinical Research Network. 3021 were of white European ethnicity and 291 (9%) were non-white. There was a small male predominance (57%). Young people <17 years comprised 59%. MAIN OUTCOME MEASURES: Autoantibody status and characteristics at presentation. RESULTS: The majority presented with classical osmotic symptoms, weight loss and fatigue. Ketoacidosis was common (42%), especially in adults, and irrespective of ethnicity. 35% were overweight or obese. Of the 1778 participants who donated a blood sample, 85% were positive for one or more autoantibodies against glutamate decarboxylase, islet antigen-2 and zinc transporter 8. Presenting symptoms were similar in the autoantibody-positive and autoantibody-negative participants, as was the frequency of ketoacidosis (43%vs40%, P=0.3). Autoantibody positivity was less common with increasing age (P=0.0001), in males compared with females (82%vs90%, P<0.0001) and in people of non-white compared with white ethnicity (73%vs86%, P<0.0001). Body mass index was higher in autoantibody-negative adults than autoantibody-positive adults (median, IQR 25.5, 23.1-29.2vs23.9, 21.4-26.7 kg/m2; P=0.0001). Autoantibody-negative participants were more likely to have a parent with diabetes (28%vs16%, P<0.0001) and less likely to have another autoimmune disease (4%vs8%, P=0.01). CONCLUSIONS: Most people assigned a diagnosis of type 1 diabetes presented with classical clinical features and islet autoantibodies. Although indistinguishable at an individual level, autoantibody-negative participants as a group ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: Electronic; application/pdf
اللغة: English
العلاقة: https://www.repository.cam.ac.uk/handle/1810/278548Test
DOI: 10.17863/CAM.25880
الإتاحة: https://doi.org/10.17863/CAM.25880Test
https://www.repository.cam.ac.uk/handle/1810/278548Test
حقوق: Attribution-NonCommercial 4.0 International ; http://creativecommons.org/licenses/by-nc/4.0Test/
رقم الانضمام: edsbas.B8D11EE
قاعدة البيانات: BASE
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