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The effect of a subcutaneous infusion of GLP-1, OXM, and PYY on energy intake and expenditure in obese volunteers

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العنوان: The effect of a subcutaneous infusion of GLP-1, OXM, and PYY on energy intake and expenditure in obese volunteers
المؤلفون: Tan, T, Behary, P, Tharakan, G, Minnion, J, Al-Najim, W, Albrechtsen, NJW, Holst, JJ, Bloom, SR
المساهمون: Medical Research Council (MRC), Imperial College Healthcare NHS Trust, National Institute for Health Research, Imperial College Healthcare NHS Trust- BRC Funding, Imperial Health Charity, Imperial College Healthcare NHS Trust - CLRN Funding
المصدر: 2372 ; 2364
بيانات النشر: Endocrine Society
سنة النشر: 2017
المجموعة: Imperial College London: Spiral
مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, GLUCAGON-LIKE PEPTIDE-1, GASTRIC BYPASS-SURGERY, PLACEBO-CONTROLLED TRIAL, FOOD-INTAKE, BARIATRIC SURGERY, WEIGHT MANAGEMENT, EATING BEHAVIOR, OXYNTOMODULIN, APPETITE, HUMANS, Adult, Analysis of Variance, Area Under Curve, Body Mass Index, Cross-Over Studies, Energy Metabolism, Female, Follow-Up Studies, Gastric Bypass, Glucagon-Like Peptide 1, Infusions, Subcutaneous, Male, Middle Aged, Obesity, Morbid, Pain Measurement
الوصف: Background: Roux-en-Y gastric bypass (RYGB) surgery is currently the most effective treatment of obesity, although limited by availability and operative risk. The gut hormones Glucagon-like peptide-1 (GLP-1), Peptide YY (PYY), and Oxyntomodulin (OXM) are elevated postprandially after RYGB, which has been postulated to contribute to its metabolic benefits. Objective: We hypothesized that infusion of the three gut hormones to achieve levels similar to those encountered postprandially in RYGB patients might be effective in suppressing appetite. The aim of this study was to investigate the effect of a continuous infusion of GLP-1, OXM, and PYY (GOP) on energy intake and expenditure in obese volunteers. Methods: Obese volunteers were randomized to receive an infusion of GOP or placebo in a single-blinded, randomized, placebo-controlled crossover study for 10.5 hours a day. This was delivered subcutaneously using a pump device, allowing volunteers to remain ambulatory. Ad libitum food intake studies were performed during the infusion, and energy expenditure was measured using a ventilated hood calorimeter. Results: Postprandial levels of GLP-1, OXM, and PYY seen post RYGB were successfully matched using 4 pmol/kg/min, 4 pmol/kg/min, and 0.4 pmol/kg/min, respectively. This dose led to a mean reduction of 32% in food intake. No significant effects on resting energy expenditure were observed. Conclusion: This is, to our knowledge, the first time that an acute continuous subcutaneous
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 0021-972X
العلاقة: Journal of Clinical Endocrinology and Metabolism; http://hdl.handle.net/10044/1/82896Test; MR/K02115X/1; RDC06 79560; RDA11 79560; P31576; 7006/R50U; G0802390; G1000474; MR/J010731/1
DOI: 10.1210/jc.2017-00469
الإتاحة: https://doi.org/10.1210/jc.2017-00469Test
http://hdl.handle.net/10044/1/82896Test
حقوق: © 2017, the authors. This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). ; https://creativecommons.org/licenses/by/4.0Test/
رقم الانضمام: edsbas.B55B8AF8
قاعدة البيانات: BASE
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