دورية أكاديمية
Q192R and L55M polymorphisms of paraoxonase 1 gene in chronic myelogenous leukemia and chronic lymphocytic leukemia
| العنوان: | Q192R and L55M polymorphisms of paraoxonase 1 gene in chronic myelogenous leukemia and chronic lymphocytic leukemia |
|---|---|
| المؤلفون: | Pehlivan, S., Sahin, H.H., Balci, S.O., Budeyri, S., Pehlivan, M., Tomatir, AyÅŸe Gaye |
| بيانات النشر: | International Institute of Anticancer Research |
| سنة النشر: | 2015 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Myelogenous, BCR-ABL Positive, Male, Middle Aged, Polymorphism, Single Nucleotide, Young Adult, genotype, human, major clinical study, polymerase chain reaction, Chronic myeoloid leukemia (CML), Chronic lymphocytic leukemia (CLL), L55M polymorphism, Paraoxonase-1 (PON1), PCR-RFLP, Q192R polymorphism, agarose, aryldialkylphosphatase 1, aryldialkylphosphatase, PON1 protein, adult, aged, allele, Article |
| الوصف: | Aim: The aim of the present study was to investigate the association between Paraoxonase 1 (PON1) gene polymorphisms Q192R, and L55M in patients with Chronic Myelogenous Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL) patients. Materials and Methods: We analyzed samples from 60 patients with CML, 60 with CLL and 84 healthy controls. Polymerase Chain Reaction (PCR) - Restriction Fragment Length Polymorphism (RLFP) was performed and samples were run in agarose gel. Results: We found statistically significant results showing an increase in both the RR genotype (p=0.044) and the R allele (p=0.011) for PON1 Q192R, and an increase in the MM genotype (p=0.007) and a decrease in the LL genotype (p=0.004) and R allele (p=0.001) in PON1 L55M in patients with CLL. Conclusion: We concluded that both the Q192R gene polymorphism with an increase in the genotype R allele, and the M/L55 with an increase in the MM genotype play a role in CLL susceptibility, and a decrease in the LL genotype can act against disease in the Turkish population. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0250-7005 |
| العلاقة: | Anticancer Research; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/10478Test; 35; 4807; 4812; 2-s2.0-84939599445; WOS:000359311000029 |
| الإتاحة: | https://hdl.handle.net/11499/10478Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.ADF9DFB9 |
| قاعدة البيانات: | BASE |
Full Text Finder | ResultId |
1 |
|---|---|
| Header |
edsbas BASE edsbas.ADF9DFB9 862 3 Academic Journal academicJournal 862.1474609375 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.ADF9DFB9&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://hdl.handle.net/11499/10478# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) [1] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edsbas&genre=article&issn=02507005&ISBN=&volume=&issue=&date=20150101&spage=&pages=&title=Q192R and L55M polymorphisms of paraoxonase 1 gene in chronic myelogenous leukemia and chronic lymphocytic leukemia&atitle=Q192R%20and%20L55M%20polymorphisms%20of%20paraoxonase%201%20gene%20in%20chronic%20myelogenous%20leukemia%20and%20chronic%20lymphocytic%20leukemia&id=DOI: [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Q192R and L55M polymorphisms of paraoxonase 1 gene in chronic myelogenous leukemia and chronic lymphocytic leukemia
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Pehlivan%2C+S%2E%22">Pehlivan, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Sahin%2C+H%2EH%2E%22">Sahin, H.H.</searchLink><br /><searchLink fieldCode="AR" term="%22Balci%2C+S%2EO%2E%22">Balci, S.O.</searchLink><br /><searchLink fieldCode="AR" term="%22Budeyri%2C+S%2E%22">Budeyri, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Pehlivan%2C+M%2E%22">Pehlivan, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Tomatir%2C+AyÅŸe+Gaye%22">Tomatir, AyÅŸe Gaye</searchLink> ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => International Institute of Anticancer Research ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2015 ) Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Leukemia%22">Leukemia</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphocytic%22">Lymphocytic</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic%22">Chronic</searchLink><br /><searchLink fieldCode="DE" term="%22B-Cell%22">B-Cell</searchLink><br /><searchLink fieldCode="DE" term="%22Myelogenous%22">Myelogenous</searchLink><br /><searchLink fieldCode="DE" term="%22BCR-ABL+Positive%22">BCR-ABL Positive</searchLink><br /><searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%22Middle+Aged%22">Middle Aged</searchLink><br /><searchLink fieldCode="DE" term="%22Polymorphism%22">Polymorphism</searchLink><br /><searchLink fieldCode="DE" term="%22Single+Nucleotide%22">Single Nucleotide</searchLink><br /><searchLink fieldCode="DE" term="%22Young+Adult%22">Young Adult</searchLink><br /><searchLink fieldCode="DE" term="%22genotype%22">genotype</searchLink><br /><searchLink fieldCode="DE" term="%22human%22">human</searchLink><br /><searchLink fieldCode="DE" term="%22major+clinical+study%22">major clinical study</searchLink><br /><searchLink fieldCode="DE" term="%22polymerase+chain+reaction%22">polymerase chain reaction</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+myeoloid+leukemia+%28CML%29%22">Chronic myeoloid leukemia (CML)</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+lymphocytic+leukemia+%28CLL%29%22">Chronic lymphocytic leukemia (CLL)</searchLink><br /><searchLink fieldCode="DE" term="%22L55M+polymorphism%22">L55M polymorphism</searchLink><br /><searchLink fieldCode="DE" term="%22Paraoxonase-1+%28PON1%29%22">Paraoxonase-1 (PON1)</searchLink><br /><searchLink fieldCode="DE" term="%22PCR-RFLP%22">PCR-RFLP</searchLink><br /><searchLink fieldCode="DE" term="%22Q192R+polymorphism%22">Q192R polymorphism</searchLink><br /><searchLink fieldCode="DE" term="%22agarose%22">agarose</searchLink><br /><searchLink fieldCode="DE" term="%22aryldialkylphosphatase+1%22">aryldialkylphosphatase 1</searchLink><br /><searchLink fieldCode="DE" term="%22aryldialkylphosphatase%22">aryldialkylphosphatase</searchLink><br /><searchLink fieldCode="DE" term="%22PON1+protein%22">PON1 protein</searchLink><br /><searchLink fieldCode="DE" term="%22adult%22">adult</searchLink><br /><searchLink fieldCode="DE" term="%22aged%22">aged</searchLink><br /><searchLink fieldCode="DE" term="%22allele%22">allele</searchLink><br /><searchLink fieldCode="DE" term="%22Article%22">Article</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Aim: The aim of the present study was to investigate the association between Paraoxonase 1 (PON1) gene polymorphisms Q192R, and L55M in patients with Chronic Myelogenous Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL) patients. Materials and Methods: We analyzed samples from 60 patients with CML, 60 with CLL and 84 healthy controls. Polymerase Chain Reaction (PCR) - Restriction Fragment Length Polymorphism (RLFP) was performed and samples were run in agarose gel. Results: We found statistically significant results showing an increase in both the RR genotype (p=0.044) and the R allele (p=0.011) for PON1 Q192R, and an increase in the MM genotype (p=0.007) and a decrease in the LL genotype (p=0.004) and R allele (p=0.001) in PON1 L55M in patients with CLL. Conclusion: We concluded that both the Q192R gene polymorphism with an increase in the genotype R allele, and the M/L55 with an increase in the MM genotype play a role in CLL susceptibility, and a decrease in the LL genotype can act against disease in the Turkish population. ) Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 0250-7005 ) Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => Anticancer Research; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/10478; 35; 4807; 4812; 2-s2.0-84939599445; WOS:000359311000029 ) Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://hdl.handle.net/11499/10478 ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => none ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.ADF9DFB9 ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Languages] => Array
(
[0] => Array
(
[Text] => English
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => Humans
[Type] => general
)
[1] => Array
(
[SubjectFull] => Leukemia
[Type] => general
)
[2] => Array
(
[SubjectFull] => Lymphocytic
[Type] => general
)
[3] => Array
(
[SubjectFull] => Chronic
[Type] => general
)
[4] => Array
(
[SubjectFull] => B-Cell
[Type] => general
)
[5] => Array
(
[SubjectFull] => Myelogenous
[Type] => general
)
[6] => Array
(
[SubjectFull] => BCR-ABL Positive
[Type] => general
)
[7] => Array
(
[SubjectFull] => Male
[Type] => general
)
[8] => Array
(
[SubjectFull] => Middle Aged
[Type] => general
)
[9] => Array
(
[SubjectFull] => Polymorphism
[Type] => general
)
[10] => Array
(
[SubjectFull] => Single Nucleotide
[Type] => general
)
[11] => Array
(
[SubjectFull] => Young Adult
[Type] => general
)
[12] => Array
(
[SubjectFull] => genotype
[Type] => general
)
[13] => Array
(
[SubjectFull] => human
[Type] => general
)
[14] => Array
(
[SubjectFull] => major clinical study
[Type] => general
)
[15] => Array
(
[SubjectFull] => polymerase chain reaction
[Type] => general
)
[16] => Array
(
[SubjectFull] => Chronic myeoloid leukemia (CML)
[Type] => general
)
[17] => Array
(
[SubjectFull] => Chronic lymphocytic leukemia (CLL)
[Type] => general
)
[18] => Array
(
[SubjectFull] => L55M polymorphism
[Type] => general
)
[19] => Array
(
[SubjectFull] => Paraoxonase-1 (PON1)
[Type] => general
)
[20] => Array
(
[SubjectFull] => PCR-RFLP
[Type] => general
)
[21] => Array
(
[SubjectFull] => Q192R polymorphism
[Type] => general
)
[22] => Array
(
[SubjectFull] => agarose
[Type] => general
)
[23] => Array
(
[SubjectFull] => aryldialkylphosphatase 1
[Type] => general
)
[24] => Array
(
[SubjectFull] => aryldialkylphosphatase
[Type] => general
)
[25] => Array
(
[SubjectFull] => PON1 protein
[Type] => general
)
[26] => Array
(
[SubjectFull] => adult
[Type] => general
)
[27] => Array
(
[SubjectFull] => aged
[Type] => general
)
[28] => Array
(
[SubjectFull] => allele
[Type] => general
)
[29] => Array
(
[SubjectFull] => Article
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Q192R and L55M polymorphisms of paraoxonase 1 gene in chronic myelogenous leukemia and chronic lymphocytic leukemia
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Pehlivan, S.
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Sahin, H.H.
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Balci, S.O.
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Budeyri, S.
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Pehlivan, M.
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Tomatir, AyÅŸe Gaye
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 01
[Type] => published
[Y] => 2015
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 02507005
)
[1] => Array
(
[Type] => issn-locals
[Value] => edsbas
)
[2] => Array
(
[Type] => issn-locals
[Value] => edsbas.oa
)
)
)
)
)
)
)
|
| IllustrationInfo |