صورة
Association Between the ACE Insertion/Deletion Polymorphism and Risk of Lower-Limb Amputation in Patients With Long-Standing Type 1 Diabetes
| العنوان: | Association Between the ACE Insertion/Deletion Polymorphism and Risk of Lower-Limb Amputation in Patients With Long-Standing Type 1 Diabetes |
|---|---|
| المؤلفون: | Kamel Mohammedi (562764), Yawa Abouleka (10189920), Charlyne Carpentier (10189923), Louis Potier (3406322), Severine Dubois (10189924), Ninon Foussard (9220301), Vincent Rigalleau (135135), Jean-François Gautier (82359), Pierre Gourdy (122444), Guillaume Charpentier (58252), Ronan Roussel (101806), André Scheen (8967179), Bernard Bauduceau (11642339), Samy Hadjadj (91107), François Alhenc-Gelas (135130), Michel Marre (91106), Gilberto Velho (562767) |
| سنة النشر: | 2021 |
| المجموعة: | Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: | Clinical Sciences not elsewhere classified, Type 1 Diabetes, Lower Limb Amputation, ACE/ID Polymorphism, Angiotensin Converting Enzyme (ACE) Activity, ACE Inhibitor(s) |
| الوصف: | OBJECTIVE. The ACE insertion/deletion (I/D) polymorphism has been widely studied in people with diabetes, albeit not regarding lower-limb amputation (LLA). We examined associations between this polymorphism, plasma ACE concentration and LLA in people with type 1 diabetes. RESEARCH DESIGN AND METHODS. ACE I/D genotype and plasma ACE were assessed in three prospective cohorts of participants with type 1 diabetes. LLA was defined as minor (below the ankle amputation consisting of at least 1-ray metatarsal resection) or major (transtibial or transfemoral) amputation. Linear, logistic and Cox regression models were computed to evaluate the likelihood of prevalent and incident LLA by ACE genotype (XD [ID or ID] versus II) and plasma ACE, after adjusting for confounders. RESULTS. Among 1301 participants (male 54%, age 41±13 years), 90 (6.9%) participants had a baseline history of LLA. Baseline LLA was more prevalent in XD (7.4%) than in II genotype (4.5%): OR 2.17 (95%CI, 1.03–4.60). Incident LLA occurred in 53 individuals during 14-year follow-up. It was higher in XD versus II carriers: HR 3.26 (1.16–13.67). This association was driven by excess risk of minor, but not major, LLA. The D-allele was associated with increased prevalent LLA at the end of follow-up (OR 2.48 [1.33–4.65]). LLA was associated with higher ACE levels in II (449 [360–539] versus 354 [286–423] ng/ml), but not in XD carriers (512 [454–570] versus 537 [488–586]). CONCLUSIONS . This is the first report of an independent association between ACE D-allele and excess LLA risk, mainly minor amputations, in patients with type 1 diabetes. |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/figure/Association_Between_the_ACE_Insertion_Deletion_Polymorphism_and_Risk_of_Lower-Limb_Amputation_in_Patients_With_Long-Standing_Type_1_Diabetes/16924237Test |
| DOI: | 10.2337/figshare.16924237.v1 |
| الإتاحة: | https://doi.org/10.2337/figshare.16924237.v1Test |
| حقوق: | CC BY-NC-SA 4.0 |
| رقم الانضمام: | edsbas.ABA0308D |
| قاعدة البيانات: | BASE |
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