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Percutaneous coronary intervention versus coronary artery bypass grafting in patients with three-vessel or left main coronary artery disease: 10-year follow-up of the multicentre randomised controlled SYNTAX trial.

التفاصيل البيبلوغرافية
العنوان: Percutaneous coronary intervention versus coronary artery bypass grafting in patients with three-vessel or left main coronary artery disease: 10-year follow-up of the multicentre randomised controlled SYNTAX trial.
المؤلفون: Thuijs, Daniel J. F. M., Kappetein, A. Pieter, Serruys, Patrick W., Mohr, Friedrich-Wilhelm, Morice, Marie-Claude, Mack, Michael J., Holmes, David R. Jr, Curzen, Nick, Davierwala, Piroze, Noack, Thilo, Milojevic, Milan, Dawkins, Keith D., da Costa, Bruno R., Juni, Peter, Head, Stuart J.
المساهمون: Casselman, Filip, de Bruyne, Bernard, Christiansen, Evald Hoj, Riuz-Nodar, Juan M, Vermeersch, Paul, Schultz, Werner, Sabate, Manel, Guagliumi, Giulio, Grubitzsch, Herko, Stangl, Karl, Darremont, Olivier, Bentala, M, den Heijer, Peter, Preda, Istvan, Stoler, Robert, Mack, Michael, Szerafin, Tamas, Buckner, John, Guber, Myles, Verberkmoes, Niels, Akca, ferdi, Feldman, Ted, Beyersdorf, Friedhelm, Drieghe, Benny, Oldroyd, Keith, Berg, Geoff, Jeppsson, Anders, Barber, Kimberly, Wolschleger, Kevin, Heiser, John, van der Harst, Pim, Mariani, Massimo, Reichenspurner, Hermann, Stark, Christoffer, Laine, Mika, Ho, Paul, Chen, John, Zelman, Richard, Horwitz, Phillip, Bochenek, Andrzef, Krauze, Agata, Grothusen, Christina, Dudek, Dariusz, Heyrich, George, Davierwala, Piroze, Noack, Thilo, Kolh, Philippe, Legrand, Victor, Coelho, Pedro, Ensminger, Stephan, Nasseri, Boris, Ingemansson, Richard, Olivecrona, Goran, Escaned, Javier, Guera, Reddy, Berti, Sergio, Morice, Marie-Claude, Chieffo, Alaide, Burke, Nicholas, Mooney, Michael, Spolaor, Alvise, Hagl, Christian, Näbauer, Michael, Suttorp, Maarten Jan, Stine, Ronald, McGarry, Thomas, Lucas, Scott, Endresen, Knut, Taussig, Andrew, Accola, Kevin, Canosi, Umberto, Horvath, Ivan, Cannon, Louis, Talbott, John, Akins, Chris, Kramer, Robert, Aschermann, Michael, Killinger, William, Narbute, Inga, Holmes, David, Burzotta, Francesco, Bogers, Ad, Zijstra, Felix, Eltchaninoff, Hélène, Berland, Jacques, Stefanini, Giulio, Gonzalez, Ignacio Cruz, Hoppe, Uta, Kiesz, Stefan, Gora, Bartlomiej, Ahlsson, Anders, Corbascio, Matthias, Bilfinger, Thomas, Carrie, Didier, Tchétché, Didier, Hauptman, Karl-Eugen, Stahle, Elisabeth, James, Stefan, Sandner, Sigrid, Laufer, Günther
المصدر: Lancet (London, England), 394 (10206), 1325-1334 (2019)
بيانات النشر: Elsevier
سنة النشر: 2019
المجموعة: University of Liège: ORBi (Open Repository and Bibliography)
مصطلحات موضوعية: Aged, Coronary Artery Bypass, Coronary Artery Disease/mortality/pathology/surgery, Drug-Eluting Stents, Female, Follow-Up Studies, Humans, Male, Middle Aged, Percutaneous Coronary Intervention, Survival Rate, Treatment Outcome, Human health sciences, Cardiovascular & respiratory systems, Sciences de la santé humaine, Systèmes cardiovasculaire & respiratoire
الوصف: peer reviewed ; BACKGROUND: The Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) trial was a non-inferiority trial that compared percutaneous coronary intervention (PCI) using first-generation paclitaxel-eluting stents with coronary artery bypass grafting (CABG) in patients with de-novo three-vessel and left main coronary artery disease, and reported results up to 5 years. We now report 10-year all-cause death results. METHODS: The SYNTAX Extended Survival (SYNTAXES) study is an investigator-driven extension of follow-up of a multicentre, randomised controlled trial done in 85 hospitals across 18 North American and European countries. Patients with de-novo three-vessel and left main coronary artery disease were randomly assigned (1:1) to the PCI group or CABG group. Patients with a history of PCI or CABG, acute myocardial infarction, or an indication for concomitant cardiac surgery were excluded. The primary endpoint of the SYNTAXES study was 10-year all-cause death, which was assessed according to the intention-to-treat principle. Prespecified subgroup analyses were performed according to the presence or absence of left main coronary artery disease and diabetes, and according to coronary complexity defined by core laboratory SYNTAX score tertiles. This study is registered with ClinicalTrials.gov, NCT03417050. FINDINGS: From March, 2005, to April, 2007, 1800 patients were randomly assigned to the PCI (n=903) or CABG (n=897) group. Vital status information at 10 years was complete for 841 (93%) patients in the PCI group and 848 (95%) patients in the CABG group. At 10 years, 244 (27%) patients had died after PCI and 211 (24%) after CABG (hazard ratio 1.17 [95% CI 0.97-1.41], p=0.092). Among patients with three-vessel disease, 151 (28%) of 546 had died after PCI versus 113 (21%) of 549 after CABG (hazard ratio 1.41 [95% CI 1.10-1.80]), and among patients with left main coronary artery disease, 93 (26%) of 357 had died after PCI versus 98 (28%) of 348 after CABG (0.90 [0.68-1.20], pinteraction=0.019). ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 0140-6736
1474-547X
العلاقة: urn:issn:0140-6736; urn:issn:1474-547X; https://orbi.uliege.be/handle/2268/250399Test; info:hdl:2268/250399; scopus-id:2-s2.0-85073022337; info:pmid:31488373
DOI: 10.1016/S0140-6736(19)31997-X
الإتاحة: https://doi.org/10.1016/S0140-6736Test(19)31997-X
https://orbi.uliege.be/handle/2268/250399Test
حقوق: restricted access ; http://purl.org/coar/access_right/c_16ecTest ; info:eu-repo/semantics/restrictedAccess
رقم الانضمام: edsbas.8FFD4548
قاعدة البيانات: BASE
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IllustrationInfo