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Middle-term outcomes in renal transplant recipients with COVID-19: A national, multicenter, controlled study

التفاصيل البيبلوغرافية
العنوان: Middle-term outcomes in renal transplant recipients with COVID-19: A national, multicenter, controlled study
المؤلفون: Oto O.A., Ozturk S., Arici M., Velio?lu A., Dursun B., Guller N., Sahin I.
بيانات النشر: Oxford University Press
سنة النشر: 2022
مصطلحات موضوعية: COVID-19, kidney transplantation, mortality, outcome, registry, alanine aminotransferase, anakinra, aspartate aminotransferase, C reactive protein, creatinine, favipiravir, ferritin, glucocorticoid, hemoglobin, lactate dehydrogenase, mycophenolic acid, serum albumin, tocilizumab, acute graft rejection, acute kidney failure, adult, alanine aminotransferase blood level, albumin blood level, antiviral therapy, arterial thromboembolism, Article, aspartate aminotransferase blood level, bk virus infection, body mass, chronic obstructive lung disease
الوصف: Background: In this study, we evaluated 3-month clinical outcomes of kidney transplant recipients (KTR) recovering from COVID-19 and compared them with a control group. Method: The primary endpoint was death in the third month. Secondary endpoints were ongoing respiratory symptoms, need for home oxygen therapy, rehospitalization for any reason, lower respiratory tract infection, urinary tract infection, biopsy-proven acute rejection, venous/arterial thromboembolic event, cytomegalovirus (CMV) infection/disease and BK viruria/viremia at 3 months. Results: A total of 944 KTR from 29 different centers were included in this study (523 patients in the COVID-19 group; 421 patients in the control group). The mean age was 46 ± 12 years (interquartile range 37-55) and 532 (56.4%) of them were male. Total number of deaths was 8 [7 (1.3%) in COVID-19 group, 1 (0.2%) in control group; P = 0.082]. The proportion of patients with ongoing respiratory symptoms [43 (8.2%) versus 4 (1.0%); P < 0.001] was statistically significantly higher in the COVID-19 group compared with the control group. There was no significant difference between the two groups in terms of other secondary endpoints. Conclusion: The prevalence of ongoing respiratory symptoms increased in the first 3 months post-COVID in KTRs who have recovered from COVID-19, but mortality was not significantly different. © 2022 The Author(s). Published by Oxford University Press on behalf of the ERA.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 20488505
العلاقة: Clinical Kidney Journal; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1093/ckj/sfac045Test; https://hdl.handle.net/20.500.12831/12849Test; 15; 999; 1006; 2-s2.0-85142620316
DOI: 10.1093/ckj/sfac045
الإتاحة: https://doi.org/10.1093/ckj/sfac045Test
https://doi.org/20.500.12831/12849Test
https://hdl.handle.net/20.500.12831/12849Test
حقوق: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.8C51C885
قاعدة البيانات: BASE
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