دورية أكاديمية
أعرض في EDS

Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis

التفاصيل البيبلوغرافية
العنوان: Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis
المؤلفون: Wood, Marnie, Powell, Lawrie, Dixon, Jeannette, Subramaniam, V. Nathan, Ramm, Grant
المصدر: World Journal of Gastroenterology
بيانات النشر: WJG Press
سنة النشر: 2013
المجموعة: Queensland University of Technology: QUT ePrints
مصطلحات موضوعية: 8-oxoguanine DNA glycosylase, Biopsy, Chemokine (C-C motif) ligand 2, Chi-Square Distribution, DNA, DNA glycosyltransferase, Genetic Association Studies, Genetic Predisposition to Disease, Genetic polymorphism, Haemochromatosis, Homozygote, Humans, Interleukin 10, Liver fibrosis, Logistic Models, Monocyte chemoattractant protein 1, Multivariate Analysis, Odds Ratio, Phenotype, Polymorphism, Risk Factors, Severity of Illness Index, Single Nucleotide, Toll-like receptor 4, Transforming growth factor beta, Young Adult, adult, alcohol consumption, article, chemokine receptor CCR2
الوصف: Aim - To investigate the role of genetic polymorphisms in the progression of hepatic fibrosis in hereditary haemochromatosis. Methods - A cohort of 245 well-characterised C282Y homozygous patients with haemochromatosis was studied, with all subjects having liver biopsy data and DNA available for testing. This study assessed the association of eight single nucleotide polymorphisms (SNPs) in a total of six genes including toll-like receptor 4 (TLR4), transforming growth factor-beta (TGF-β), oxoguanine DNA glycosylase, monocyte chemoattractant protein 1, chemokine C-C motif receptor 2 and interleukin-10 with liver disease severity. Genotyping was performed using high resolution melt analysis and sequencing. The results were analysed in relation to the stage of hepatic fibrosis in multivariate analysis incorporating other cofactors including alcohol consumption and hepatic iron concentration. Results - There were significant associations between the cofactors of male gender (P = 0.0001), increasing age (P = 0.006), alcohol consumption (P = 0.0001), steatosis (P = 0.03), hepatic iron concentration (P < 0.0001) and the presence of hepatic fibrosis. Of the candidate gene polymorphisms studied, none showed a significant association with hepatic fibrosis in univariate or multivariate analysis incorporating cofactors. We also specifically studied patients with hepatic iron loading above threshold levels for cirrhosis and compared the genetic polymorphisms between those with no fibrosis vs cirrhosis however there was no significant effect from any of the candidate genes studied. Importantly, in this large, well characterised cohort of patients there was no association between SNPs for TGF-β or TLR4 and the presence of fibrosis, cirrhosis or increasing fibrosis stage in multivariate analysis. Conclusion - In our large, well characterised group of haemochromatosis subjects we did not demonstrate any relationship between candidate gene polymorphisms and hepatic fibrosis or cirrhosis.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: unknown
العلاقة: https://eprints.qut.edu.au/101157/1/WJG-19-9366.pdfTest; Wood, Marnie, Powell, Lawrie, Dixon, Jeannette, Subramaniam, V. Nathan, & Ramm, Grant (2013) Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis. World Journal of Gastroenterology, 19(48), pp. 9366-9376.; https://eprints.qut.edu.au/101157Test/
الإتاحة: https://doi.org/10.3748/wjg.v19.i48.9366Test
https://eprints.qut.edu.au/101157Test/
حقوق: free_to_read ; http://creativecommons.org/licenses/by-nc/2.5Test/ ; Consult author(s) regarding copyright matters ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au
رقم الانضمام: edsbas.84A37DD0
قاعدة البيانات: BASE
ResultId 1
Header edsbas
BASE
edsbas.84A37DD0
847
3
Academic Journal
academicJournal
846.889038085938
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.84A37DD0&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://doi.org/10.3748/wjg.v19.i48.9366# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wood%2C+Marnie%22&quot;&gt;Wood, Marnie&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Powell%2C+Lawrie%22&quot;&gt;Powell, Lawrie&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dixon%2C+Jeannette%22&quot;&gt;Dixon, Jeannette&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Subramaniam%2C+V%2E+Nathan%22&quot;&gt;Subramaniam, V. Nathan&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ramm%2C+Grant%22&quot;&gt;Ramm, Grant&lt;/searchLink&gt; )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => World Journal of Gastroenterology )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => WJG Press )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2013 )
Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => Queensland University of Technology: QUT ePrints )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%228-oxoguanine+DNA+glycosylase%22&quot;&gt;8-oxoguanine DNA glycosylase&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Biopsy%22&quot;&gt;Biopsy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Chemokine+%28C-C+motif%29+ligand+2%22&quot;&gt;Chemokine (C-C motif) ligand 2&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Chi-Square+Distribution%22&quot;&gt;Chi-Square Distribution&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22DNA%22&quot;&gt;DNA&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22DNA+glycosyltransferase%22&quot;&gt;DNA glycosyltransferase&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Genetic+Association+Studies%22&quot;&gt;Genetic Association Studies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Genetic+Predisposition+to+Disease%22&quot;&gt;Genetic Predisposition to Disease&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Genetic+polymorphism%22&quot;&gt;Genetic polymorphism&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Haemochromatosis%22&quot;&gt;Haemochromatosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Homozygote%22&quot;&gt;Homozygote&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Interleukin+10%22&quot;&gt;Interleukin 10&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Liver+fibrosis%22&quot;&gt;Liver fibrosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Logistic+Models%22&quot;&gt;Logistic Models&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Monocyte+chemoattractant+protein+1%22&quot;&gt;Monocyte chemoattractant protein 1&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Multivariate+Analysis%22&quot;&gt;Multivariate Analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Odds+Ratio%22&quot;&gt;Odds Ratio&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Phenotype%22&quot;&gt;Phenotype&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Polymorphism%22&quot;&gt;Polymorphism&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Risk+Factors%22&quot;&gt;Risk Factors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Severity+of+Illness+Index%22&quot;&gt;Severity of Illness Index&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Single+Nucleotide%22&quot;&gt;Single Nucleotide&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Toll-like+receptor+4%22&quot;&gt;Toll-like receptor 4&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Transforming+growth+factor+beta%22&quot;&gt;Transforming growth factor beta&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Young+Adult%22&quot;&gt;Young Adult&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22adult%22&quot;&gt;adult&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22alcohol+consumption%22&quot;&gt;alcohol consumption&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22article%22&quot;&gt;article&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22chemokine+receptor+CCR2%22&quot;&gt;chemokine receptor CCR2&lt;/searchLink&gt; )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Aim - To investigate the role of genetic polymorphisms in the progression of hepatic fibrosis in hereditary haemochromatosis. Methods - A cohort of 245 well-characterised C282Y homozygous patients with haemochromatosis was studied, with all subjects having liver biopsy data and DNA available for testing. This study assessed the association of eight single nucleotide polymorphisms (SNPs) in a total of six genes including toll-like receptor 4 (TLR4), transforming growth factor-beta (TGF-β), oxoguanine DNA glycosylase, monocyte chemoattractant protein 1, chemokine C-C motif receptor 2 and interleukin-10 with liver disease severity. Genotyping was performed using high resolution melt analysis and sequencing. The results were analysed in relation to the stage of hepatic fibrosis in multivariate analysis incorporating other cofactors including alcohol consumption and hepatic iron concentration. Results - There were significant associations between the cofactors of male gender (P = 0.0001), increasing age (P = 0.006), alcohol consumption (P = 0.0001), steatosis (P = 0.03), hepatic iron concentration (P &lt; 0.0001) and the presence of hepatic fibrosis. Of the candidate gene polymorphisms studied, none showed a significant association with hepatic fibrosis in univariate or multivariate analysis incorporating cofactors. We also specifically studied patients with hepatic iron loading above threshold levels for cirrhosis and compared the genetic polymorphisms between those with no fibrosis vs cirrhosis however there was no significant effect from any of the candidate genes studied. Importantly, in this large, well characterised cohort of patients there was no association between SNPs for TGF-β or TLR4 and the presence of fibrosis, cirrhosis or increasing fibrosis stage in multivariate analysis. Conclusion - In our large, well characterised group of haemochromatosis subjects we did not demonstrate any relationship between candidate gene polymorphisms and hepatic fibrosis or cirrhosis. )
Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper )
Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => application/pdf )
Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => unknown )
Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => https://eprints.qut.edu.au/101157/1/WJG-19-9366.pdf; Wood, Marnie, Powell, Lawrie, Dixon, Jeannette, Subramaniam, V. Nathan, &amp; Ramm, Grant (2013) Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis. World Journal of Gastroenterology, 19(48), pp. 9366-9376.; https://eprints.qut.edu.au/101157/ )
Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://doi.org/10.3748/wjg.v19.i48.9366&lt;br /&gt;https://eprints.qut.edu.au/101157/ )
Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => free_to_read ; http://creativecommons.org/licenses/by-nc/2.5/ ; Consult author(s) regarding copyright matters ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.84A37DD0 )
RecordInfo Array ( [BibEntity] => Array ( [Languages] => Array ( [0] => Array ( [Text] => unknown ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => 8-oxoguanine DNA glycosylase [Type] => general ) [1] => Array ( [SubjectFull] => Biopsy [Type] => general ) [2] => Array ( [SubjectFull] => Chemokine (C-C motif) ligand 2 [Type] => general ) [3] => Array ( [SubjectFull] => Chi-Square Distribution [Type] => general ) [4] => Array ( [SubjectFull] => DNA [Type] => general ) [5] => Array ( [SubjectFull] => DNA glycosyltransferase [Type] => general ) [6] => Array ( [SubjectFull] => Genetic Association Studies [Type] => general ) [7] => Array ( [SubjectFull] => Genetic Predisposition to Disease [Type] => general ) [8] => Array ( [SubjectFull] => Genetic polymorphism [Type] => general ) [9] => Array ( [SubjectFull] => Haemochromatosis [Type] => general ) [10] => Array ( [SubjectFull] => Homozygote [Type] => general ) [11] => Array ( [SubjectFull] => Humans [Type] => general ) [12] => Array ( [SubjectFull] => Interleukin 10 [Type] => general ) [13] => Array ( [SubjectFull] => Liver fibrosis [Type] => general ) [14] => Array ( [SubjectFull] => Logistic Models [Type] => general ) [15] => Array ( [SubjectFull] => Monocyte chemoattractant protein 1 [Type] => general ) [16] => Array ( [SubjectFull] => Multivariate Analysis [Type] => general ) [17] => Array ( [SubjectFull] => Odds Ratio [Type] => general ) [18] => Array ( [SubjectFull] => Phenotype [Type] => general ) [19] => Array ( [SubjectFull] => Polymorphism [Type] => general ) [20] => Array ( [SubjectFull] => Risk Factors [Type] => general ) [21] => Array ( [SubjectFull] => Severity of Illness Index [Type] => general ) [22] => Array ( [SubjectFull] => Single Nucleotide [Type] => general ) [23] => Array ( [SubjectFull] => Toll-like receptor 4 [Type] => general ) [24] => Array ( [SubjectFull] => Transforming growth factor beta [Type] => general ) [25] => Array ( [SubjectFull] => Young Adult [Type] => general ) [26] => Array ( [SubjectFull] => adult [Type] => general ) [27] => Array ( [SubjectFull] => alcohol consumption [Type] => general ) [28] => Array ( [SubjectFull] => article [Type] => general ) [29] => Array ( [SubjectFull] => chemokine receptor CCR2 [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Wood, Marnie ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Powell, Lawrie ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Dixon, Jeannette ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Subramaniam, V. Nathan ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Ramm, Grant ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 01 [Type] => published [Y] => 2013 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-locals [Value] => edsbas ) [1] => Array ( [Type] => issn-locals [Value] => edsbas.oa ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => World Journal of Gastroenterology [Type] => main ) ) ) ) ) ) )
IllustrationInfo