مؤتمر
A fully integrated electrochemical bioMEMS fabrication process for cytokine detection: application for heart failure
| العنوان: | A fully integrated electrochemical bioMEMS fabrication process for cytokine detection: application for heart failure |
|---|---|
| المؤلفون: | Baraket, Abdoullatif, Lee, Michael, Zine, Nadia, Sigaud, Monique, Zabala, Miguel, Bausells, Joan, Errachid, Abdelhamid |
| المساهمون: | ISA-Micro & Nanobiotechnologies, Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Instituto de Microelectrònica de Barcelona (IMB-CNM), Consejo Superior de Investigaciones Cientificas España = Spanish National Research Council Spain (CSIC)-Centro Nacional de Microelectronica Spain (CNM) |
| المصدر: | EUROSENSORS 2014, the 28th European Conference on Solid-State Transducers ; https://hal.science/hal-01363713Test ; EUROSENSORS 2014, the 28th European Conference on Solid-State Transducers, Sep 2014, Brescia, Italy. pp.377-379, ⟨10.1016/j.proeng.2014.11.737⟩ |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2014 |
| المجموعة: | HAL Lyon 1 (University Claude Bernard Lyon 1) |
| مصطلحات موضوعية: | BioMEMS, heart failure, impedance spectroscopy, cytokine biomarkers, microtechnology, [CHIM.ANAL]Chemical Sciences/Analytical chemistry |
| جغرافية الموضوع: | Brescia, Italy |
| الوصف: | International audience ; In this present study, a fully integrated BioMEMS was developed using silicon technology to simultaneously detect varying cytokine biomarkers: interleukin-1 (IL-1), interleukin-10 (IL-10), and interleukin-6 (IL-6) using eight gold working microelectrodes (WE). The biomarkers are one of many antigens that are secreted in acute stages of inflammation after left ventricle assisted device (LVAD) implantation for patients suffering from heart failure (HF). The monoclonal antibodies (mAb): anti-human IL-1, IL-10, and IL-6 were immobilized onto gold microelectrodes through functionalization with carboxyl diazonium, respectively. Cyclic voltammetry (CV) was applied during the microelectrode functionalization process to characterize the gold microelectrode surface properties, while electrochemical impedance spectroscopy (EIS) was used to characterize the modified gold microelectrodes. The BioMEMS was highly sensitive towards the three cytokines in a range of 1 pg/mL to 15 pg/mL, which is the window where acute inflammations were observed. |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| العلاقة: | hal-01363713; https://hal.science/hal-01363713Test |
| DOI: | 10.1016/j.proeng.2014.11.737 |
| الإتاحة: | https://doi.org/10.1016/j.proeng.2014.11.737Test https://hal.science/hal-01363713Test |
| رقم الانضمام: | edsbas.7A0C987 |
| قاعدة البيانات: | BASE |
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