دورية أكاديمية
Effectiveness of Modified Vaccinia Ankara-Bavaria Nordic Vaccination in a Population at High Risk of Mpox: A Spanish Cohort Study
| العنوان: | Effectiveness of Modified Vaccinia Ankara-Bavaria Nordic Vaccination in a Population at High Risk of Mpox: A Spanish Cohort Study |
|---|---|
| المؤلفون: | Fontán-Vela, Mario, Hernando, Victoria, Olmedo, Carmen, Coma, Ermengol, Martínez, Montse, Moreno-Perez, David, Lorusso, Nicola, Vázquez Torres, María, Barbas del Buey, José Francisco, Roig-Sena, Javier, Pastor, Eliseo, Galmés Truyols, Antònia, Artigues Serra, Francisca, Sancho Martínez, Rosa María, Latasa Zamalloa, Pello, Pérez Martínez, Olaia, Vázquez Estepa, Ana, García Rojas, Amós José, Barreno Estévez, Ana Isabel, Sánchez-Migallón Naranjo, Alonso, Pérez Martín, Jaime Jesús, Peces Jiménez, Pilar, Morales Romero, Raquel, Castilla, Jesús, García Cenoz, Manuel, Huerta Huerta, Marta, Boone, An Lieve Dirk, Macías Ortiz, María José, Álvarez Río, Virginia, Rodríguez Recio, María Jesús, Merino Díaz, María, Berradre Sáenz, Belén, Villegas-Moreno, María Teresa, Limia, Aurora, Diaz, Asuncion, Monge, Susana, Rodrigo, José Antonio Lluch, Juaneda, Juan, Malonda, Rosa Carbo, Mendioroz, Jacobo, Farran, Joan Colom, Carril, Fernando González, Echevarría, Lorea Oscoz, Barros, María Teresa Otero, Gaiche, Nuria Suárez, Martínez, José Angélica Gómez, Bastante, Borja Alcázar, Santos, Rocío Sánchez, Sanjurjo, Lucía Fuster, del Carmen Pacheco Martínez, María |
| المصدر: | Clinical Infectious Diseases ; volume 78, issue 2, page 476-483 ; ISSN 1058-4838 1537-6591 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| الوصف: | Background With more than 7500 cases reported since April 2022, Spain has experienced the highest incidence of mpox in Europe. From 12 July onward, the modified vaccinia Ankara-Bavaria Nordic (MVA-BN) smallpox vaccine was offered as pre-exposure prophylaxis for those receiving pre-exposure prophylaxis for human immunodeficiency virus (HIV-PrEP). Our aim was to assess the effectiveness of 1 dose of MVA-BN vaccine as pre-exposure prophylaxis against mpox virus (MPXV) infection in persons on HIV-PrEP. Methods National retrospective cohort study between 12 July and 12 December 2022. Individuals aged ≥18 years receiving HIV-PrEP as of 12 July with no previous MPXV infection or vaccination were eligible. Each day, we matched individuals receiving a first dose of vaccine and unvaccinated controls of the same age and region. We used a Kaplan–Meier estimator, calculated risk ratios (RR) and vaccine effectiveness (VE = [1 − RR]x100). Results We included 5660 matched pairs, with a median follow-up of 62 days (interquartile range, 24–97). Mpox cumulative incidence was 5.6 per 1000 (25 cases) in unvaccinated and 3.5 per 1000 (18 cases) in vaccinated. No effect was found during days 0–6 post-vaccination (VE, −38.3; 95% confidence interval [CI], −332.7 to 46.4), but VE was 65% at ≥7 days (95% CI, 22.9 to 88.0) and 79% at ≥14 days (95% CI, 33.3 to 100.0) post-vaccination. Conclusions One dose of MVA-BN vaccine offered protection against mpox in most-at-risk population shortly after the vaccination. Further studies need to assess the VE of a second dose and the duration of protection over time. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/cid/ciad645 |
| DOI: | 10.1093/cid/ciad645/54948558/ciad645.pdf |
| الإتاحة: | https://doi.org/10.1093/cid/ciad645Test https://academic.oup.com/cid/article-pdf/78/2/476/56697890/ciad645.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.76ECC9E8 |
| قاعدة البيانات: | BASE |
| ResultId |
1 |
|---|---|
| Header |
edsbas BASE edsbas.76ECC9E8 975 3 Academic Journal academicJournal 975.149597167969 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.76ECC9E8&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://doi.org/10.1093/cid/ciad645# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Effectiveness of Modified Vaccinia Ankara-Bavaria Nordic Vaccination in a Population at High Risk of Mpox: A Spanish Cohort Study
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Fontán-Vela%2C+Mario%22">Fontán-Vela, Mario</searchLink><br /><searchLink fieldCode="AR" term="%22Hernando%2C+Victoria%22">Hernando, Victoria</searchLink><br /><searchLink fieldCode="AR" term="%22Olmedo%2C+Carmen%22">Olmedo, Carmen</searchLink><br /><searchLink fieldCode="AR" term="%22Coma%2C+Ermengol%22">Coma, Ermengol</searchLink><br /><searchLink fieldCode="AR" term="%22Martínez%2C+Montse%22">Martínez, Montse</searchLink><br /><searchLink fieldCode="AR" term="%22Moreno-Perez%2C+David%22">Moreno-Perez, David</searchLink><br /><searchLink fieldCode="AR" term="%22Lorusso%2C+Nicola%22">Lorusso, Nicola</searchLink><br /><searchLink fieldCode="AR" term="%22Vázquez+Torres%2C+María%22">Vázquez Torres, María</searchLink><br /><searchLink fieldCode="AR" term="%22Barbas+del+Buey%2C+José+Francisco%22">Barbas del Buey, José Francisco</searchLink><br /><searchLink fieldCode="AR" term="%22Roig-Sena%2C+Javier%22">Roig-Sena, Javier</searchLink><br /><searchLink fieldCode="AR" term="%22Pastor%2C+Eliseo%22">Pastor, Eliseo</searchLink><br /><searchLink fieldCode="AR" term="%22Galmés+Truyols%2C+Antònia%22">Galmés Truyols, Antònia</searchLink><br /><searchLink fieldCode="AR" term="%22Artigues+Serra%2C+Francisca%22">Artigues Serra, Francisca</searchLink><br /><searchLink fieldCode="AR" term="%22Sancho+Martínez%2C+Rosa+María%22">Sancho Martínez, Rosa María</searchLink><br /><searchLink fieldCode="AR" term="%22Latasa+Zamalloa%2C+Pello%22">Latasa Zamalloa, Pello</searchLink><br /><searchLink fieldCode="AR" term="%22Pérez+Martínez%2C+Olaia%22">Pérez Martínez, Olaia</searchLink><br /><searchLink fieldCode="AR" term="%22Vázquez+Estepa%2C+Ana%22">Vázquez Estepa, Ana</searchLink><br /><searchLink fieldCode="AR" term="%22García+Rojas%2C+Amós+José%22">García Rojas, Amós José</searchLink><br /><searchLink fieldCode="AR" term="%22Barreno+Estévez%2C+Ana+Isabel%22">Barreno Estévez, Ana Isabel</searchLink><br /><searchLink fieldCode="AR" term="%22Sánchez-Migallón+Naranjo%2C+Alonso%22">Sánchez-Migallón Naranjo, Alonso</searchLink><br /><searchLink fieldCode="AR" term="%22Pérez+Martín%2C+Jaime+Jesús%22">Pérez Martín, Jaime Jesús</searchLink><br /><searchLink fieldCode="AR" term="%22Peces+Jiménez%2C+Pilar%22">Peces Jiménez, Pilar</searchLink><br /><searchLink fieldCode="AR" term="%22Morales+Romero%2C+Raquel%22">Morales Romero, Raquel</searchLink><br /><searchLink fieldCode="AR" term="%22Castilla%2C+Jesús%22">Castilla, Jesús</searchLink><br /><searchLink fieldCode="AR" term="%22García+Cenoz%2C+Manuel%22">García Cenoz, Manuel</searchLink><br /><searchLink fieldCode="AR" term="%22Huerta+Huerta%2C+Marta%22">Huerta Huerta, Marta</searchLink><br /><searchLink fieldCode="AR" term="%22Boone%2C+An+Lieve+Dirk%22">Boone, An Lieve Dirk</searchLink><br /><searchLink fieldCode="AR" term="%22Macías+Ortiz%2C+María+José%22">Macías Ortiz, María José</searchLink><br /><searchLink fieldCode="AR" term="%22Álvarez+Río%2C+Virginia%22">Álvarez Río, Virginia</searchLink><br /><searchLink fieldCode="AR" term="%22Rodríguez+Recio%2C+María+Jesús%22">Rodríguez Recio, María Jesús</searchLink><br /><searchLink fieldCode="AR" term="%22Merino+Díaz%2C+María%22">Merino Díaz, María</searchLink><br /><searchLink fieldCode="AR" term="%22Berradre+Sáenz%2C+Belén%22">Berradre Sáenz, Belén</searchLink><br /><searchLink fieldCode="AR" term="%22Villegas-Moreno%2C+María+Teresa%22">Villegas-Moreno, María Teresa</searchLink><br /><searchLink fieldCode="AR" term="%22Limia%2C+Aurora%22">Limia, Aurora</searchLink><br /><searchLink fieldCode="AR" term="%22Diaz%2C+Asuncion%22">Diaz, Asuncion</searchLink><br /><searchLink fieldCode="AR" term="%22Monge%2C+Susana%22">Monge, Susana</searchLink><br /><searchLink fieldCode="AR" term="%22Rodrigo%2C+José+Antonio+Lluch%22">Rodrigo, José Antonio Lluch</searchLink><br /><searchLink fieldCode="AR" term="%22Juaneda%2C+Juan%22">Juaneda, Juan</searchLink><br /><searchLink fieldCode="AR" term="%22Malonda%2C+Rosa+Carbo%22">Malonda, Rosa Carbo</searchLink><br /><searchLink fieldCode="AR" term="%22Mendioroz%2C+Jacobo%22">Mendioroz, Jacobo</searchLink><br /><searchLink fieldCode="AR" term="%22Farran%2C+Joan+Colom%22">Farran, Joan Colom</searchLink><br /><searchLink fieldCode="AR" term="%22Carril%2C+Fernando+González%22">Carril, Fernando González</searchLink><br /><searchLink fieldCode="AR" term="%22Echevarría%2C+Lorea+Oscoz%22">Echevarría, Lorea Oscoz</searchLink><br /><searchLink fieldCode="AR" term="%22Barros%2C+María+Teresa+Otero%22">Barros, María Teresa Otero</searchLink><br /><searchLink fieldCode="AR" term="%22Gaiche%2C+Nuria+Suárez%22">Gaiche, Nuria Suárez</searchLink><br /><searchLink fieldCode="AR" term="%22Martínez%2C+José+Angélica+Gómez%22">Martínez, José Angélica Gómez</searchLink><br /><searchLink fieldCode="AR" term="%22Bastante%2C+Borja+Alcázar%22">Bastante, Borja Alcázar</searchLink><br /><searchLink fieldCode="AR" term="%22Santos%2C+Rocío+Sánchez%22">Santos, Rocío Sánchez</searchLink><br /><searchLink fieldCode="AR" term="%22Sanjurjo%2C+Lucía+Fuster%22">Sanjurjo, Lucía Fuster</searchLink><br /><searchLink fieldCode="AR" term="%22del+Carmen+Pacheco+Martínez%2C+María%22">del Carmen Pacheco Martínez, María</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Clinical Infectious Diseases ; volume 78, issue 2, page 476-483 ; ISSN 1058-4838 1537-6591 ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Oxford University Press (OUP) ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2023 ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Background With more than 7500 cases reported since April 2022, Spain has experienced the highest incidence of mpox in Europe. From 12 July onward, the modified vaccinia Ankara-Bavaria Nordic (MVA-BN) smallpox vaccine was offered as pre-exposure prophylaxis for those receiving pre-exposure prophylaxis for human immunodeficiency virus (HIV-PrEP). Our aim was to assess the effectiveness of 1 dose of MVA-BN vaccine as pre-exposure prophylaxis against mpox virus (MPXV) infection in persons on HIV-PrEP. Methods National retrospective cohort study between 12 July and 12 December 2022. Individuals aged ≥18 years receiving HIV-PrEP as of 12 July with no previous MPXV infection or vaccination were eligible. Each day, we matched individuals receiving a first dose of vaccine and unvaccinated controls of the same age and region. We used a Kaplan–Meier estimator, calculated risk ratios (RR) and vaccine effectiveness (VE = [1 − RR]x100). Results We included 5660 matched pairs, with a median follow-up of 62 days (interquartile range, 24–97). Mpox cumulative incidence was 5.6 per 1000 (25 cases) in unvaccinated and 3.5 per 1000 (18 cases) in vaccinated. No effect was found during days 0–6 post-vaccination (VE, −38.3; 95% confidence interval [CI], −332.7 to 46.4), but VE was 65% at ≥7 days (95% CI, 22.9 to 88.0) and 79% at ≥14 days (95% CI, 33.3 to 100.0) post-vaccination. Conclusions One dose of MVA-BN vaccine offered protection against mpox in most-at-risk population shortly after the vaccination. Further studies need to assess the VE of a second dose and the duration of protection over time. ) Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1093/cid/ciad645 ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1093/cid/ciad645/54948558/ciad645.pdf ) Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://doi.org/10.1093/cid/ciad645<br />https://academic.oup.com/cid/article-pdf/78/2/476/56697890/ciad645.pdf ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => https://creativecommons.org/licenses/by/4.0/ ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.76ECC9E8 ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1093/cid/ciad645
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => English
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Effectiveness of Modified Vaccinia Ankara-Bavaria Nordic Vaccination in a Population at High Risk of Mpox: A Spanish Cohort Study
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Fontán-Vela, Mario
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Hernando, Victoria
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Olmedo, Carmen
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Coma, Ermengol
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Martínez, Montse
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Moreno-Perez, David
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Lorusso, Nicola
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Vázquez Torres, María
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Barbas del Buey, José Francisco
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Roig-Sena, Javier
)
)
)
[10] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Pastor, Eliseo
)
)
)
[11] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Galmés Truyols, Antònia
)
)
)
[12] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Artigues Serra, Francisca
)
)
)
[13] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Sancho Martínez, Rosa María
)
)
)
[14] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Latasa Zamalloa, Pello
)
)
)
[15] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Pérez Martínez, Olaia
)
)
)
[16] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Vázquez Estepa, Ana
)
)
)
[17] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => García Rojas, Amós José
)
)
)
[18] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Barreno Estévez, Ana Isabel
)
)
)
[19] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Sánchez-Migallón Naranjo, Alonso
)
)
)
[20] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Pérez Martín, Jaime Jesús
)
)
)
[21] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Peces Jiménez, Pilar
)
)
)
[22] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Morales Romero, Raquel
)
)
)
[23] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Castilla, Jesús
)
)
)
[24] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => García Cenoz, Manuel
)
)
)
[25] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Huerta Huerta, Marta
)
)
)
[26] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Boone, An Lieve Dirk
)
)
)
[27] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Macías Ortiz, María José
)
)
)
[28] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Álvarez Río, Virginia
)
)
)
[29] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Rodríguez Recio, María Jesús
)
)
)
[30] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Merino Díaz, María
)
)
)
[31] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Berradre Sáenz, Belén
)
)
)
[32] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Villegas-Moreno, María Teresa
)
)
)
[33] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Limia, Aurora
)
)
)
[34] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Diaz, Asuncion
)
)
)
[35] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Monge, Susana
)
)
)
[36] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Rodrigo, José Antonio Lluch
)
)
)
[37] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Juaneda, Juan
)
)
)
[38] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Malonda, Rosa Carbo
)
)
)
[39] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Mendioroz, Jacobo
)
)
)
[40] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Farran, Joan Colom
)
)
)
[41] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Carril, Fernando González
)
)
)
[42] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Echevarría, Lorea Oscoz
)
)
)
[43] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Barros, María Teresa Otero
)
)
)
[44] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Gaiche, Nuria Suárez
)
)
)
[45] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Martínez, José Angélica Gómez
)
)
)
[46] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Bastante, Borja Alcázar
)
)
)
[47] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Santos, Rocío Sánchez
)
)
)
[48] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Sanjurjo, Lucía Fuster
)
)
)
[49] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => del Carmen Pacheco Martínez, María
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 01
[Type] => published
[Y] => 2023
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-locals
[Value] => edsbas
)
[1] => Array
(
[Type] => issn-locals
[Value] => edsbas.oa
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Clinical Infectious Diseases ; volume 78, issue 2, page 476-483 ; ISSN 1058-4838 1537-6591
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |