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Clinical and Molecular-Genetic Insights into the Role of Oxidative Stress in Diabetic Retinopathy: Antioxidant Strategies and Future Avenues

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العنوان: Clinical and Molecular-Genetic Insights into the Role of Oxidative Stress in Diabetic Retinopathy: Antioxidant Strategies and Future Avenues
المؤلفون: Silvia Sanz-González, José García-Medina, Vicente Zanón-Moreno, María López-Gálvez, David Galarreta-Mira, Lilianne Duarte, Mar Valero-Velló, Ana Ramírez, J. Arévalo, María Pinazo-Durán, on behalf of the Valencia Study Group on Diabetic Retinopathy (VSDR) Report number 4
المصدر: Antioxidants; Volume 9; Issue 11; Pages: 1101
بيانات النشر: Multidisciplinary Digital Publishing Institute
سنة النشر: 2020
المجموعة: MDPI Open Access Publishing
مصطلحات موضوعية: type 2 diabetes mellitus, retinopathy, oxidative stress, antioxidants, omega-3 fatty acids, candidate biomarkers, prevention of blindness
جغرافية الموضوع: agris
الوصف: Reactive oxygen species (ROS) overproduction and ROS-signaling pathways activation attack the eyes. We evaluated the oxidative stress (OS) and the effects of a daily, core nutritional supplement regimen containing antioxidants and omega 3 fatty acids (A/ω3) in type 2 diabetics (T2DM). A case-control study was carried out in 480 participants [287 T2DM patients with (+)/without (−) diabetic retinopathy (DR) and 193 healthy controls (CG)], randomly assigned to a daily pill of A/ω3. Periodic evaluation through 38 months allowed to outline patient characteristics, DR features, and classic/OS blood parameters. Statistics were performed by the SPSS 24.0 program. Diabetics displayed significantly higher circulating pro-oxidants (p = 0.001) and lower antioxidants (p = 0.0001) than the controls. Significantly higher plasma malondialdehyde/thiobarbituric acid reactive substances (MDA/TBARS; p = 0.006) and lower plasma total antioxidant capacity (TAC; p = 0.042) and vitamin C (0.020) was found in T2DM + DR versus T2DM-DR. The differential expression profile of solute carrier family 23 member 2 (SLC23A2) gene was seen in diabetics versus the CG (p = 0.001), and in T2DM + DR versus T2DM − DR (p < 0.05). The A/ω3 regime significantly reduced the pro-oxidants (p < 0.05) and augmented the antioxidants (p < 0.05). This follow-up study supports that a regular A/ω3 supplementation reduces the oxidative load and may serve as a dietary prophylaxis/adjunctive intervention for patients at risk of diabetic blindness.
نوع الوثيقة: text
وصف الملف: application/pdf
اللغة: English
العلاقة: Health Outcomes of Antioxidants and Oxidative Stress; https://dx.doi.org/10.3390/antiox9111101Test
DOI: 10.3390/antiox9111101
الإتاحة: https://doi.org/10.3390/antiox9111101Test
حقوق: https://creativecommons.org/licenses/by/4.0Test/
رقم الانضمام: edsbas.6D22621B
قاعدة البيانات: BASE
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