دورية أكاديمية
The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma
| العنوان: | The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma |
|---|---|
| المؤلفون: | Wagener, R., Seufert, J., Raimondi, F., Bens, S., Kleinheinz, K., Nagel, I., Altmueller, J., Thiele, H., Huebschmann, D., Kohler, Christian, Nürnberg, P., Au-Yeung, R., Burkhardt, B., Horn, H., Leoncini, L., Jaffe, E. S., Ott, G., Rymkiewicz, G., Schlesner, M., Russell, R. B., Klapper, W., Siebert, R. |
| بيانات النشر: | AMER SOC HEMATOLOGY |
| سنة النشر: | 2018 |
| المجموعة: | University of Regensburg Publication Server |
| مصطلحات موضوعية: | 610 Medizin, ddc:610 |
| الوصف: | The new recently described provisional lymphoma category Burkitt-like lymphoma with 11q aberration comprises cases similar to Burkitt lymphoma (BL) on morphological, immunophenotypic and gene-expression levels but lacking the IG-MYC translocation. They are characterized by a peculiar imbalance pattern on chromosome 11, but the landscape of mutations is not yet described. Thus, we investigated 15 MYC-negative Burkitt-like lymphoma with 11q aberration (mnBLL, 11q,) cases by copy-number analysis and whole-exome sequencing. We refined the regions of 11q imbalance and identified the INO80 complex-associated gene NFRKB as a positional candidate in 11q24.3. Next to recurrent gains in 12q13.11-q24.32 and 7q34-qter as well as losses in 13q32.3-q34, we identified 47 genes recurrently affected by protein-changing mutations (each >= 3 of 15 cases). Strikingly, we did not detect recurrent mutations in genes of the ID3-TCF3 axis or the SWI/SNF complex that are frequently altered in BL, or in genes frequently mutated in germinal center-derived B-cell lymphomas like KMT2D or CREBBP. An exception is GNA13, which was mutated in 7 of 15 cases. We conclude that the genomic landscape of mnBLL, 11q, differs from that of BL both at the chromosomal and mutational levels. Our findings implicate that mnBLL, 11q, is a lymphoma category distinct from BL at the molecular level. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Wagener, R., Seufert, J., Raimondi, F., Bens, S., Kleinheinz, K., Nagel, I., Altmueller, J., Thiele, H., Huebschmann, D., Kohler, Christian, Nürnberg, P., Au-Yeung, R., Burkhardt, B., Horn, H., Leoncini, L., Jaffe, E. S., Ott, G., Rymkiewicz, G. , Schlesner, M. , Russell, R. B. , Klapper, W. und Siebert, R. (2018) The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma. Blood. |
| الإتاحة: | https://epub.uni-regensburg.de/38169Test/ http://www.bloodjournal.org/content/early/2018/12/19/blood-2018-07-864025Test |
| رقم الانضمام: | edsbas.69A2D0D2 |
| قاعدة البيانات: | BASE |
| ResultId |
1 |
|---|---|
| Header |
edsbas BASE edsbas.69A2D0D2 821 3 Academic Journal academicJournal 821.334289550781 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.69A2D0D2&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://epub.uni-regensburg.de/38169/# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Wagener%2C+R%2E%22">Wagener, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Seufert%2C+J%2E%22">Seufert, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Raimondi%2C+F%2E%22">Raimondi, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Bens%2C+S%2E%22">Bens, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Kleinheinz%2C+K%2E%22">Kleinheinz, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Nagel%2C+I%2E%22">Nagel, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Altmueller%2C+J%2E%22">Altmueller, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Thiele%2C+H%2E%22">Thiele, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Huebschmann%2C+D%2E%22">Huebschmann, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Kohler%2C+Christian%22">Kohler, Christian</searchLink><br /><searchLink fieldCode="AR" term="%22Nürnberg%2C+P%2E%22">Nürnberg, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Au-Yeung%2C+R%2E%22">Au-Yeung, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Burkhardt%2C+B%2E%22">Burkhardt, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Horn%2C+H%2E%22">Horn, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Leoncini%2C+L%2E%22">Leoncini, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Jaffe%2C+E%2E+S%2E%22">Jaffe, E. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Ott%2C+G%2E%22">Ott, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Rymkiewicz%2C+G%2E%22">Rymkiewicz, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Schlesner%2C+M%2E%22">Schlesner, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Russell%2C+R%2E+B%2E%22">Russell, R. B.</searchLink><br /><searchLink fieldCode="AR" term="%22Klapper%2C+W%2E%22">Klapper, W.</searchLink><br /><searchLink fieldCode="AR" term="%22Siebert%2C+R%2E%22">Siebert, R.</searchLink> ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => AMER SOC HEMATOLOGY ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2018 ) Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => University of Regensburg Publication Server ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22610+Medizin%22">610 Medizin</searchLink><br /><searchLink fieldCode="DE" term="%22ddc%3A610%22">ddc:610</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => The new recently described provisional lymphoma category Burkitt-like lymphoma with 11q aberration comprises cases similar to Burkitt lymphoma (BL) on morphological, immunophenotypic and gene-expression levels but lacking the IG-MYC translocation. They are characterized by a peculiar imbalance pattern on chromosome 11, but the landscape of mutations is not yet described. Thus, we investigated 15 MYC-negative Burkitt-like lymphoma with 11q aberration (mnBLL, 11q,) cases by copy-number analysis and whole-exome sequencing. We refined the regions of 11q imbalance and identified the INO80 complex-associated gene NFRKB as a positional candidate in 11q24.3. Next to recurrent gains in 12q13.11-q24.32 and 7q34-qter as well as losses in 13q32.3-q34, we identified 47 genes recurrently affected by protein-changing mutations (each >= 3 of 15 cases). Strikingly, we did not detect recurrent mutations in genes of the ID3-TCF3 axis or the SWI/SNF complex that are frequently altered in BL, or in genes frequently mutated in germinal center-derived B-cell lymphomas like KMT2D or CREBBP. An exception is GNA13, which was mutated in 7 of 15 cases. We conclude that the genomic landscape of mnBLL, 11q, differs from that of BL both at the chromosomal and mutational levels. Our findings implicate that mnBLL, 11q, is a lymphoma category distinct from BL at the molecular level. ) Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => unknown ) Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => Wagener, R., Seufert, J., Raimondi, F., Bens, S., Kleinheinz, K., Nagel, I., Altmueller, J., Thiele, H., Huebschmann, D., Kohler, Christian, Nürnberg, P., Au-Yeung, R., Burkhardt, B., Horn, H., Leoncini, L., Jaffe, E. S., Ott, G., Rymkiewicz, G. , Schlesner, M. , Russell, R. B. , Klapper, W. und Siebert, R. (2018) The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma. Blood. ) Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://epub.uni-regensburg.de/38169/<br />http://www.bloodjournal.org/content/early/2018/12/19/blood-2018-07-864025 ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.69A2D0D2 ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Languages] => Array
(
[0] => Array
(
[Text] => unknown
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => 610 Medizin
[Type] => general
)
[1] => Array
(
[SubjectFull] => ddc:610
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Wagener, R.
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Seufert, J.
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Raimondi, F.
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Bens, S.
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kleinheinz, K.
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Nagel, I.
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Altmueller, J.
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Thiele, H.
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Huebschmann, D.
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kohler, Christian
)
)
)
[10] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Nürnberg, P.
)
)
)
[11] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Au-Yeung, R.
)
)
)
[12] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Burkhardt, B.
)
)
)
[13] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Horn, H.
)
)
)
[14] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Leoncini, L.
)
)
)
[15] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jaffe, E. S.
)
)
)
[16] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Ott, G.
)
)
)
[17] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Rymkiewicz, G.
)
)
)
[18] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Schlesner, M.
)
)
)
[19] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Russell, R. B.
)
)
)
[20] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Klapper, W.
)
)
)
[21] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Siebert, R.
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 01
[Type] => published
[Y] => 2018
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-locals
[Value] => edsbas
)
)
)
)
)
)
)
|
| IllustrationInfo |