دورية أكاديمية
أعرض في EDS

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

التفاصيل البيبلوغرافية
العنوان: Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
المؤلفون: Schmidt, Amand F, Holmes, Michael V, Preiss, David, Swerdlow, Daniel I, Denaxas, Spiros, Fatemifar, Ghazaleh, Faraway, Rupert, Finan, Chris, Valentine, Dennis, Fairhurst-Hunter, Zammy, Hartwig, Fernando Pires, Horta, Bernardo Lessa, Hypponen, Elina, Power, Christine, Moldovan, Max, van Iperen, Erik, Hovingh, Kees, Demuth, Ilja, Norman, Kristina, Steinhagen-Thiessen, Elisabeth, Demuth, Juri, Bertram, Lars, Lill, Christina M, Coassin, Stefan, Willeit, Johann, Kiechl, Stefan, Willeit, Karin, Mason, Dan, Wright, John, Morris, Richard, Wanamethee, Goya, Whincup, Peter, Ben-Shlomo, Yoav, McLachlan, Stela, Price, Jackie F, Kivimaki, Mika, Welch, Catherine, Sanchez-Galvez, Adelaida, Marques-Vidal, Pedro, Nicolaides, Andrew, Panayiotou, Andrie G, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Matullo, Giuseppe, Fiorito, Giovanni, Guarrera, Simonetta, Sacerdote, Carlotta, Wareham, Nicholas J, Langenberg, Claudia, Scott, Robert A, Luan, Jian'an, Bobak, Martin, Malyutina, Sofia, Pająk, Andrzej, Kubinova, Ruzena, Tamosiunas, Abdonas, Pikhart, Hynek, Grarup, Niels, Pedersen, Oluf, Hansen, Torben, Linneberg, Allan, Jess, Tine, Cooper, Jackie, Humphries, Steve E, Brilliant, Murray, Kitchner, Terrie, Hakonarson, Hakon, Carrell, David S, McCarty, Catherine A, Lester, Kirchner H, Larson, Eric B, Crosslin, David R, de Andrade, Mariza, Roden, Dan M, Denny, Joshua C, Carty, Cara, Hancock, Stephen, Attia, John, Holliday, Elizabeth, Scott, Rodney, Schofield, Peter, O'Donnell, Martin, Yusuf, Salim, Chong, Michael, Pare, Guillaume, van der Harst, Pim, Said, M Abdullah, Eppinga, Ruben N, Verweij, Niek, Snieder, Harold, Christen, Tim, Mook-Kanamori, D O, Gustafsson, Stefan, Lind, Lars, Ingelsson, Erik, Pazoki, Raha, Franco, Oscar, Hofman, Albert, Uitterlinden, Andre, Dehghan, Abbas, Teumer, Alexander, Baumeister, Sebastian, Dörr, Marcus, Lerch, Markus M, Völker, Uwe, Völzke, Henry, Ward, Joey, Pell, Jill P, Meade, Tom, Christophersen, Ingrid E, Maitland-van der Zee, Anke H, Baranova, Ekaterina V, Young, Robin, Ford, Ian, Campbell, Archie, Padmanabhan, Sandosh, Bots, Michiel L, Grobbee, Diederick E, Froguel, Philippe, Thuillier, Dorothée, Roussel, Ronan, Bonnefond, Amélie, Cariou, Bertrand, Smart, Melissa, Bao, Yanchun, Kumari, Meena, Mahajan, Anubha, Hopewell, Jemma C, Seshadri, Sudha, Dale, Caroline, Costa, Rui Providencia E, Ridker, Paul M, Chasman, Daniel I, Reiner, Alex P, Ritchie, Marylyn D, Lange, Leslie A, Cornish, Alex J, Dobbins, Sara E, Hemminki, Kari, Kinnersley, Ben, Sanson, Marc, Labreche, Karim, Simon, Matthias, Bondy, Melissa, Law, Philip, Speedy, Helen, Allan, James, Li, Ni, Went, Molly, Weinhold, Niels, Morgan, Gareth, Sonneveld, Pieter, Nilsson, Björn, Goldschmidt, Hartmut, Sud, Amit, Engert, Andreas, Hansson, Markus, Hemingway, Harry, Asselbergs, Folkert W, Patel, Riyaz S, Keating, Brendan J, Sattar, Naveed, Houlston, Richard, Casas, Juan P, Hingorani, Aroon D
المصدر: BMC cardiovascular disorders, London : BioMed Central, 2019, vol. 19, no. 1, 240, p. 1-10 ; eISSN 1471-2261
سنة النشر: 2019
المجموعة: LSRC VL (Lithuanian Social Research Centre Virtual Library) / LSTC VB (Lietuvos socialinių tyrimų centras virtualią biblioteką)
مصطلحات موضوعية: Genetic association studies, LDL-cholesterol, Mendelian randomisation, Phenome-wide association scan
الوصف: BACKGROUND: We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. METHODS: Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Seventeen randomized placebo controlled PCSK9 inhibitor trials were included, providing data on 79,578 participants. Results were scaled to a one mmol/L lower LDL-C concentration. RESULTS: The PCSK9 GS (comprising 4 SNPs) associations with plasma lipid and apolipoprotein levels were consistent in direction with treatment effects. The GS odds ratio (OR) for myocardial infarction (MI) was 0.53 (95% CI 0.42; 0.68), compared to a PCSK9 inhibitor effect of 0.90 (95% CI 0.86; 0.93). For ischemic stroke ORs were 0.84 (95% CI 0.57; 1.22) for the GS, compared to 0.85 (95% CI 0.78; 0.93) in the drug trials. ORs with type 2 diabetes mellitus (T2DM) were 1.29 (95% CI 1.11; 1.50) for the GS, as compared to 1.00 (95% CI 0.96; 1.04) for incident T2DM in PCSK9 inhibitor trials. No genetic associations were observed for cancer, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, or Alzheimer's disease - outcomes for which large-scale trial data were unavailable. CONCLUSIONS: Genetic variation at the PCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI. While indicating an increased risk of T2DM, no other possible safety concerns were shown; although precision was moderate.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
العلاقة: http://lsmu.oai.elaba.lt/documents/42516597.pdfTest; http://lsmu.lvb.lt/LSMU:ELABAPDB42516597&prefLang=en_USTest
الإتاحة: https://doi.org/10.1186/s12872-019-1187-zTest
http://lsmu.oai.elaba.lt/documents/42516597.pdfTest
http://lsmu.lvb.lt/LSMU:ELABAPDB42516597&prefLang=en_USTest
حقوق: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.68776EAF
قاعدة البيانات: BASE
ResultId 1
Header edsbas
BASE
edsbas.68776EAF
904
3
Academic Journal
academicJournal
903.687927246094
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.68776EAF&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://doi.org/10.1186/s12872-019-1187-z# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9 )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Schmidt%2C+Amand+F%22">Schmidt, Amand F</searchLink><br /><searchLink fieldCode="AR" term="%22Holmes%2C+Michael+V%22">Holmes, Michael V</searchLink><br /><searchLink fieldCode="AR" term="%22Preiss%2C+David%22">Preiss, David</searchLink><br /><searchLink fieldCode="AR" term="%22Swerdlow%2C+Daniel+I%22">Swerdlow, Daniel I</searchLink><br /><searchLink fieldCode="AR" term="%22Denaxas%2C+Spiros%22">Denaxas, Spiros</searchLink><br /><searchLink fieldCode="AR" term="%22Fatemifar%2C+Ghazaleh%22">Fatemifar, Ghazaleh</searchLink><br /><searchLink fieldCode="AR" term="%22Faraway%2C+Rupert%22">Faraway, Rupert</searchLink><br /><searchLink fieldCode="AR" term="%22Finan%2C+Chris%22">Finan, Chris</searchLink><br /><searchLink fieldCode="AR" term="%22Valentine%2C+Dennis%22">Valentine, Dennis</searchLink><br /><searchLink fieldCode="AR" term="%22Fairhurst-Hunter%2C+Zammy%22">Fairhurst-Hunter, Zammy</searchLink><br /><searchLink fieldCode="AR" term="%22Hartwig%2C+Fernando+Pires%22">Hartwig, Fernando Pires</searchLink><br /><searchLink fieldCode="AR" term="%22Horta%2C+Bernardo+Lessa%22">Horta, Bernardo Lessa</searchLink><br /><searchLink fieldCode="AR" term="%22Hypponen%2C+Elina%22">Hypponen, Elina</searchLink><br /><searchLink fieldCode="AR" term="%22Power%2C+Christine%22">Power, Christine</searchLink><br /><searchLink fieldCode="AR" term="%22Moldovan%2C+Max%22">Moldovan, Max</searchLink><br /><searchLink fieldCode="AR" term="%22van+Iperen%2C+Erik%22">van Iperen, Erik</searchLink><br /><searchLink fieldCode="AR" term="%22Hovingh%2C+Kees%22">Hovingh, Kees</searchLink><br /><searchLink fieldCode="AR" term="%22Demuth%2C+Ilja%22">Demuth, Ilja</searchLink><br /><searchLink fieldCode="AR" term="%22Norman%2C+Kristina%22">Norman, Kristina</searchLink><br /><searchLink fieldCode="AR" term="%22Steinhagen-Thiessen%2C+Elisabeth%22">Steinhagen-Thiessen, Elisabeth</searchLink><br /><searchLink fieldCode="AR" term="%22Demuth%2C+Juri%22">Demuth, Juri</searchLink><br /><searchLink fieldCode="AR" term="%22Bertram%2C+Lars%22">Bertram, Lars</searchLink><br /><searchLink fieldCode="AR" term="%22Lill%2C+Christina+M%22">Lill, Christina M</searchLink><br /><searchLink fieldCode="AR" term="%22Coassin%2C+Stefan%22">Coassin, Stefan</searchLink><br /><searchLink fieldCode="AR" term="%22Willeit%2C+Johann%22">Willeit, Johann</searchLink><br /><searchLink fieldCode="AR" term="%22Kiechl%2C+Stefan%22">Kiechl, Stefan</searchLink><br /><searchLink fieldCode="AR" term="%22Willeit%2C+Karin%22">Willeit, Karin</searchLink><br /><searchLink fieldCode="AR" term="%22Mason%2C+Dan%22">Mason, Dan</searchLink><br /><searchLink fieldCode="AR" term="%22Wright%2C+John%22">Wright, John</searchLink><br /><searchLink fieldCode="AR" term="%22Morris%2C+Richard%22">Morris, Richard</searchLink><br /><searchLink fieldCode="AR" term="%22Wanamethee%2C+Goya%22">Wanamethee, Goya</searchLink><br /><searchLink fieldCode="AR" term="%22Whincup%2C+Peter%22">Whincup, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22Ben-Shlomo%2C+Yoav%22">Ben-Shlomo, Yoav</searchLink><br /><searchLink fieldCode="AR" term="%22McLachlan%2C+Stela%22">McLachlan, Stela</searchLink><br /><searchLink fieldCode="AR" term="%22Price%2C+Jackie+F%22">Price, Jackie F</searchLink><br /><searchLink fieldCode="AR" term="%22Kivimaki%2C+Mika%22">Kivimaki, Mika</searchLink><br /><searchLink fieldCode="AR" term="%22Welch%2C+Catherine%22">Welch, Catherine</searchLink><br /><searchLink fieldCode="AR" term="%22Sanchez-Galvez%2C+Adelaida%22">Sanchez-Galvez, Adelaida</searchLink><br /><searchLink fieldCode="AR" term="%22Marques-Vidal%2C+Pedro%22">Marques-Vidal, Pedro</searchLink><br /><searchLink fieldCode="AR" term="%22Nicolaides%2C+Andrew%22">Nicolaides, Andrew</searchLink><br /><searchLink fieldCode="AR" term="%22Panayiotou%2C+Andrie+G%22">Panayiotou, Andrie G</searchLink><br /><searchLink fieldCode="AR" term="%22Onland-Moret%2C+N+Charlotte%22">Onland-Moret, N Charlotte</searchLink><br /><searchLink fieldCode="AR" term="%22van+der+Schouw%2C+Yvonne+T%22">van der Schouw, Yvonne T</searchLink><br /><searchLink fieldCode="AR" term="%22Matullo%2C+Giuseppe%22">Matullo, Giuseppe</searchLink><br /><searchLink fieldCode="AR" term="%22Fiorito%2C+Giovanni%22">Fiorito, Giovanni</searchLink><br /><searchLink fieldCode="AR" term="%22Guarrera%2C+Simonetta%22">Guarrera, Simonetta</searchLink><br /><searchLink fieldCode="AR" term="%22Sacerdote%2C+Carlotta%22">Sacerdote, Carlotta</searchLink><br /><searchLink fieldCode="AR" term="%22Wareham%2C+Nicholas+J%22">Wareham, Nicholas J</searchLink><br /><searchLink fieldCode="AR" term="%22Langenberg%2C+Claudia%22">Langenberg, Claudia</searchLink><br /><searchLink fieldCode="AR" term="%22Scott%2C+Robert+A%22">Scott, Robert A</searchLink><br /><searchLink fieldCode="AR" term="%22Luan%2C+Jian'an%22">Luan, Jian'an</searchLink><br /><searchLink fieldCode="AR" term="%22Bobak%2C+Martin%22">Bobak, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22Malyutina%2C+Sofia%22">Malyutina, Sofia</searchLink><br /><searchLink fieldCode="AR" term="%22Pająk%2C+Andrzej%22">Pająk, Andrzej</searchLink><br /><searchLink fieldCode="AR" term="%22Kubinova%2C+Ruzena%22">Kubinova, Ruzena</searchLink><br /><searchLink fieldCode="AR" term="%22Tamosiunas%2C+Abdonas%22">Tamosiunas, Abdonas</searchLink><br /><searchLink fieldCode="AR" term="%22Pikhart%2C+Hynek%22">Pikhart, Hynek</searchLink><br /><searchLink fieldCode="AR" term="%22Grarup%2C+Niels%22">Grarup, Niels</searchLink><br /><searchLink fieldCode="AR" term="%22Pedersen%2C+Oluf%22">Pedersen, Oluf</searchLink><br /><searchLink fieldCode="AR" term="%22Hansen%2C+Torben%22">Hansen, Torben</searchLink><br /><searchLink fieldCode="AR" term="%22Linneberg%2C+Allan%22">Linneberg, Allan</searchLink><br /><searchLink fieldCode="AR" term="%22Jess%2C+Tine%22">Jess, Tine</searchLink><br /><searchLink fieldCode="AR" term="%22Cooper%2C+Jackie%22">Cooper, Jackie</searchLink><br /><searchLink fieldCode="AR" term="%22Humphries%2C+Steve+E%22">Humphries, Steve E</searchLink><br /><searchLink fieldCode="AR" term="%22Brilliant%2C+Murray%22">Brilliant, Murray</searchLink><br /><searchLink fieldCode="AR" term="%22Kitchner%2C+Terrie%22">Kitchner, Terrie</searchLink><br /><searchLink fieldCode="AR" term="%22Hakonarson%2C+Hakon%22">Hakonarson, Hakon</searchLink><br /><searchLink fieldCode="AR" term="%22Carrell%2C+David+S%22">Carrell, David S</searchLink><br /><searchLink fieldCode="AR" term="%22McCarty%2C+Catherine+A%22">McCarty, Catherine A</searchLink><br /><searchLink fieldCode="AR" term="%22Lester%2C+Kirchner+H%22">Lester, Kirchner H</searchLink><br /><searchLink fieldCode="AR" term="%22Larson%2C+Eric+B%22">Larson, Eric B</searchLink><br /><searchLink fieldCode="AR" term="%22Crosslin%2C+David+R%22">Crosslin, David R</searchLink><br /><searchLink fieldCode="AR" term="%22de+Andrade%2C+Mariza%22">de Andrade, Mariza</searchLink><br /><searchLink fieldCode="AR" term="%22Roden%2C+Dan+M%22">Roden, Dan M</searchLink><br /><searchLink fieldCode="AR" term="%22Denny%2C+Joshua+C%22">Denny, Joshua C</searchLink><br /><searchLink fieldCode="AR" term="%22Carty%2C+Cara%22">Carty, Cara</searchLink><br /><searchLink fieldCode="AR" term="%22Hancock%2C+Stephen%22">Hancock, Stephen</searchLink><br /><searchLink fieldCode="AR" term="%22Attia%2C+John%22">Attia, John</searchLink><br /><searchLink fieldCode="AR" term="%22Holliday%2C+Elizabeth%22">Holliday, Elizabeth</searchLink><br /><searchLink fieldCode="AR" term="%22Scott%2C+Rodney%22">Scott, Rodney</searchLink><br /><searchLink fieldCode="AR" term="%22Schofield%2C+Peter%22">Schofield, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22O'Donnell%2C+Martin%22">O'Donnell, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22Yusuf%2C+Salim%22">Yusuf, Salim</searchLink><br /><searchLink fieldCode="AR" term="%22Chong%2C+Michael%22">Chong, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Pare%2C+Guillaume%22">Pare, Guillaume</searchLink><br /><searchLink fieldCode="AR" term="%22van+der+Harst%2C+Pim%22">van der Harst, Pim</searchLink><br /><searchLink fieldCode="AR" term="%22Said%2C+M+Abdullah%22">Said, M Abdullah</searchLink><br /><searchLink fieldCode="AR" term="%22Eppinga%2C+Ruben+N%22">Eppinga, Ruben N</searchLink><br /><searchLink fieldCode="AR" term="%22Verweij%2C+Niek%22">Verweij, Niek</searchLink><br /><searchLink fieldCode="AR" term="%22Snieder%2C+Harold%22">Snieder, Harold</searchLink><br /><searchLink fieldCode="AR" term="%22Christen%2C+Tim%22">Christen, Tim</searchLink><br /><searchLink fieldCode="AR" term="%22Mook-Kanamori%2C+D+O%22">Mook-Kanamori, D O</searchLink><br /><searchLink fieldCode="AR" term="%22Gustafsson%2C+Stefan%22">Gustafsson, Stefan</searchLink><br /><searchLink fieldCode="AR" term="%22Lind%2C+Lars%22">Lind, Lars</searchLink><br /><searchLink fieldCode="AR" term="%22Ingelsson%2C+Erik%22">Ingelsson, Erik</searchLink><br /><searchLink fieldCode="AR" term="%22Pazoki%2C+Raha%22">Pazoki, Raha</searchLink><br /><searchLink fieldCode="AR" term="%22Franco%2C+Oscar%22">Franco, Oscar</searchLink><br /><searchLink fieldCode="AR" term="%22Hofman%2C+Albert%22">Hofman, Albert</searchLink><br /><searchLink fieldCode="AR" term="%22Uitterlinden%2C+Andre%22">Uitterlinden, Andre</searchLink><br /><searchLink fieldCode="AR" term="%22Dehghan%2C+Abbas%22">Dehghan, Abbas</searchLink><br /><searchLink fieldCode="AR" term="%22Teumer%2C+Alexander%22">Teumer, Alexander</searchLink><br /><searchLink fieldCode="AR" term="%22Baumeister%2C+Sebastian%22">Baumeister, Sebastian</searchLink><br /><searchLink fieldCode="AR" term="%22Dörr%2C+Marcus%22">Dörr, Marcus</searchLink><br /><searchLink fieldCode="AR" term="%22Lerch%2C+Markus+M%22">Lerch, Markus M</searchLink><br /><searchLink fieldCode="AR" term="%22Völker%2C+Uwe%22">Völker, Uwe</searchLink><br /><searchLink fieldCode="AR" term="%22Völzke%2C+Henry%22">Völzke, Henry</searchLink><br /><searchLink fieldCode="AR" term="%22Ward%2C+Joey%22">Ward, Joey</searchLink><br /><searchLink fieldCode="AR" term="%22Pell%2C+Jill+P%22">Pell, Jill P</searchLink><br /><searchLink fieldCode="AR" term="%22Meade%2C+Tom%22">Meade, Tom</searchLink><br /><searchLink fieldCode="AR" term="%22Christophersen%2C+Ingrid+E%22">Christophersen, Ingrid E</searchLink><br /><searchLink fieldCode="AR" term="%22Maitland-van+der+Zee%2C+Anke+H%22">Maitland-van der Zee, Anke H</searchLink><br /><searchLink fieldCode="AR" term="%22Baranova%2C+Ekaterina+V%22">Baranova, Ekaterina V</searchLink><br /><searchLink fieldCode="AR" term="%22Young%2C+Robin%22">Young, Robin</searchLink><br /><searchLink fieldCode="AR" term="%22Ford%2C+Ian%22">Ford, Ian</searchLink><br /><searchLink fieldCode="AR" term="%22Campbell%2C+Archie%22">Campbell, Archie</searchLink><br /><searchLink fieldCode="AR" term="%22Padmanabhan%2C+Sandosh%22">Padmanabhan, Sandosh</searchLink><br /><searchLink fieldCode="AR" term="%22Bots%2C+Michiel+L%22">Bots, Michiel L</searchLink><br /><searchLink fieldCode="AR" term="%22Grobbee%2C+Diederick+E%22">Grobbee, Diederick E</searchLink><br /><searchLink fieldCode="AR" term="%22Froguel%2C+Philippe%22">Froguel, Philippe</searchLink><br /><searchLink fieldCode="AR" term="%22Thuillier%2C+Dorothée%22">Thuillier, Dorothée</searchLink><br /><searchLink fieldCode="AR" term="%22Roussel%2C+Ronan%22">Roussel, Ronan</searchLink><br /><searchLink fieldCode="AR" term="%22Bonnefond%2C+Amélie%22">Bonnefond, Amélie</searchLink><br /><searchLink fieldCode="AR" term="%22Cariou%2C+Bertrand%22">Cariou, Bertrand</searchLink><br /><searchLink fieldCode="AR" term="%22Smart%2C+Melissa%22">Smart, Melissa</searchLink><br /><searchLink fieldCode="AR" term="%22Bao%2C+Yanchun%22">Bao, Yanchun</searchLink><br /><searchLink fieldCode="AR" term="%22Kumari%2C+Meena%22">Kumari, Meena</searchLink><br /><searchLink fieldCode="AR" term="%22Mahajan%2C+Anubha%22">Mahajan, Anubha</searchLink><br /><searchLink fieldCode="AR" term="%22Hopewell%2C+Jemma+C%22">Hopewell, Jemma C</searchLink><br /><searchLink fieldCode="AR" term="%22Seshadri%2C+Sudha%22">Seshadri, Sudha</searchLink><br /><searchLink fieldCode="AR" term="%22Dale%2C+Caroline%22">Dale, Caroline</searchLink><br /><searchLink fieldCode="AR" term="%22Costa%2C+Rui+Providencia+E%22">Costa, Rui Providencia E</searchLink><br /><searchLink fieldCode="AR" term="%22Ridker%2C+Paul+M%22">Ridker, Paul M</searchLink><br /><searchLink fieldCode="AR" term="%22Chasman%2C+Daniel+I%22">Chasman, Daniel I</searchLink><br /><searchLink fieldCode="AR" term="%22Reiner%2C+Alex+P%22">Reiner, Alex P</searchLink><br /><searchLink fieldCode="AR" term="%22Ritchie%2C+Marylyn+D%22">Ritchie, Marylyn D</searchLink><br /><searchLink fieldCode="AR" term="%22Lange%2C+Leslie+A%22">Lange, Leslie A</searchLink><br /><searchLink fieldCode="AR" term="%22Cornish%2C+Alex+J%22">Cornish, Alex J</searchLink><br /><searchLink fieldCode="AR" term="%22Dobbins%2C+Sara+E%22">Dobbins, Sara E</searchLink><br /><searchLink fieldCode="AR" term="%22Hemminki%2C+Kari%22">Hemminki, Kari</searchLink><br /><searchLink fieldCode="AR" term="%22Kinnersley%2C+Ben%22">Kinnersley, Ben</searchLink><br /><searchLink fieldCode="AR" term="%22Sanson%2C+Marc%22">Sanson, Marc</searchLink><br /><searchLink fieldCode="AR" term="%22Labreche%2C+Karim%22">Labreche, Karim</searchLink><br /><searchLink fieldCode="AR" term="%22Simon%2C+Matthias%22">Simon, Matthias</searchLink><br /><searchLink fieldCode="AR" term="%22Bondy%2C+Melissa%22">Bondy, Melissa</searchLink><br /><searchLink fieldCode="AR" term="%22Law%2C+Philip%22">Law, Philip</searchLink><br /><searchLink fieldCode="AR" term="%22Speedy%2C+Helen%22">Speedy, Helen</searchLink><br /><searchLink fieldCode="AR" term="%22Allan%2C+James%22">Allan, James</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Ni%22">Li, Ni</searchLink><br /><searchLink fieldCode="AR" term="%22Went%2C+Molly%22">Went, Molly</searchLink><br /><searchLink fieldCode="AR" term="%22Weinhold%2C+Niels%22">Weinhold, Niels</searchLink><br /><searchLink fieldCode="AR" term="%22Morgan%2C+Gareth%22">Morgan, Gareth</searchLink><br /><searchLink fieldCode="AR" term="%22Sonneveld%2C+Pieter%22">Sonneveld, Pieter</searchLink><br /><searchLink fieldCode="AR" term="%22Nilsson%2C+Björn%22">Nilsson, Björn</searchLink><br /><searchLink fieldCode="AR" term="%22Goldschmidt%2C+Hartmut%22">Goldschmidt, Hartmut</searchLink><br /><searchLink fieldCode="AR" term="%22Sud%2C+Amit%22">Sud, Amit</searchLink><br /><searchLink fieldCode="AR" term="%22Engert%2C+Andreas%22">Engert, Andreas</searchLink><br /><searchLink fieldCode="AR" term="%22Hansson%2C+Markus%22">Hansson, Markus</searchLink><br /><searchLink fieldCode="AR" term="%22Hemingway%2C+Harry%22">Hemingway, Harry</searchLink><br /><searchLink fieldCode="AR" term="%22Asselbergs%2C+Folkert+W%22">Asselbergs, Folkert W</searchLink><br /><searchLink fieldCode="AR" term="%22Patel%2C+Riyaz+S%22">Patel, Riyaz S</searchLink><br /><searchLink fieldCode="AR" term="%22Keating%2C+Brendan+J%22">Keating, Brendan J</searchLink><br /><searchLink fieldCode="AR" term="%22Sattar%2C+Naveed%22">Sattar, Naveed</searchLink><br /><searchLink fieldCode="AR" term="%22Houlston%2C+Richard%22">Houlston, Richard</searchLink><br /><searchLink fieldCode="AR" term="%22Casas%2C+Juan+P%22">Casas, Juan P</searchLink><br /><searchLink fieldCode="AR" term="%22Hingorani%2C+Aroon+D%22">Hingorani, Aroon D</searchLink> )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => BMC cardiovascular disorders, London : BioMed Central, 2019, vol. 19, no. 1, 240, p. 1-10 ; eISSN 1471-2261 )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2019 )
Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => LSRC VL (Lithuanian Social Research Centre Virtual Library) / LSTC VB (Lietuvos socialinių tyrimų centras virtualią biblioteką) )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Genetic+association+studies%22">Genetic association studies</searchLink><br /><searchLink fieldCode="DE" term="%22LDL-cholesterol%22">LDL-cholesterol</searchLink><br /><searchLink fieldCode="DE" term="%22Mendelian+randomisation%22">Mendelian randomisation</searchLink><br /><searchLink fieldCode="DE" term="%22Phenome-wide+association+scan%22">Phenome-wide association scan</searchLink> )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => BACKGROUND: We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. METHODS: Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Seventeen randomized placebo controlled PCSK9 inhibitor trials were included, providing data on 79,578 participants. Results were scaled to a one mmol/L lower LDL-C concentration. RESULTS: The PCSK9 GS (comprising 4 SNPs) associations with plasma lipid and apolipoprotein levels were consistent in direction with treatment effects. The GS odds ratio (OR) for myocardial infarction (MI) was 0.53 (95% CI 0.42; 0.68), compared to a PCSK9 inhibitor effect of 0.90 (95% CI 0.86; 0.93). For ischemic stroke ORs were 0.84 (95% CI 0.57; 1.22) for the GS, compared to 0.85 (95% CI 0.78; 0.93) in the drug trials. ORs with type 2 diabetes mellitus (T2DM) were 1.29 (95% CI 1.11; 1.50) for the GS, as compared to 1.00 (95% CI 0.96; 1.04) for incident T2DM in PCSK9 inhibitor trials. No genetic associations were observed for cancer, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, or Alzheimer's disease - outcomes for which large-scale trial data were unavailable. CONCLUSIONS: Genetic variation at the PCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI. While indicating an increased risk of T2DM, no other possible safety concerns were shown; although precision was moderate. )
Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper )
Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => application/pdf )
Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English )
Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => http://lsmu.oai.elaba.lt/documents/42516597.pdf; http://lsmu.lvb.lt/LSMU:ELABAPDB42516597&prefLang=en_US )
Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://doi.org/10.1186/s12872-019-1187-z<br />http://lsmu.oai.elaba.lt/documents/42516597.pdf<br />http://lsmu.lvb.lt/LSMU:ELABAPDB42516597&prefLang=en_US )
Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => info:eu-repo/semantics/openAccess )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.68776EAF )
RecordInfo Array ( [BibEntity] => Array ( [Languages] => Array ( [0] => Array ( [Text] => English ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => Genetic association studies [Type] => general ) [1] => Array ( [SubjectFull] => LDL-cholesterol [Type] => general ) [2] => Array ( [SubjectFull] => Mendelian randomisation [Type] => general ) [3] => Array ( [SubjectFull] => Phenome-wide association scan [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9 [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Schmidt, Amand F ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Holmes, Michael V ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Preiss, David ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Swerdlow, Daniel I ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Denaxas, Spiros ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Fatemifar, Ghazaleh ) ) ) [6] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Faraway, Rupert ) ) ) [7] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Finan, Chris ) ) ) [8] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Valentine, Dennis ) ) ) [9] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Fairhurst-Hunter, Zammy ) ) ) [10] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hartwig, Fernando Pires ) ) ) [11] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Horta, Bernardo Lessa ) ) ) [12] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hypponen, Elina ) ) ) [13] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Power, Christine ) ) ) [14] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Moldovan, Max ) ) ) [15] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => van Iperen, Erik ) ) ) [16] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hovingh, Kees ) ) ) [17] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Demuth, Ilja ) ) ) [18] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Norman, Kristina ) ) ) [19] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Steinhagen-Thiessen, Elisabeth ) ) ) [20] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Demuth, Juri ) ) ) [21] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Bertram, Lars ) ) ) [22] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lill, Christina M ) ) ) [23] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Coassin, Stefan ) ) ) [24] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Willeit, Johann ) ) ) [25] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Kiechl, Stefan ) ) ) [26] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Willeit, Karin ) ) ) [27] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Mason, Dan ) ) ) [28] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Wright, John ) ) ) [29] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Morris, Richard ) ) ) [30] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Wanamethee, Goya ) ) ) [31] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Whincup, Peter ) ) ) [32] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Ben-Shlomo, Yoav ) ) ) [33] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => McLachlan, Stela ) ) ) [34] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Price, Jackie F ) ) ) [35] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Kivimaki, Mika ) ) ) [36] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Welch, Catherine ) ) ) [37] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Sanchez-Galvez, Adelaida ) ) ) [38] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Marques-Vidal, Pedro ) ) ) [39] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Nicolaides, Andrew ) ) ) [40] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Panayiotou, Andrie G ) ) ) [41] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Onland-Moret, N Charlotte ) ) ) [42] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => van der Schouw, Yvonne T ) ) ) [43] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Matullo, Giuseppe ) ) ) [44] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Fiorito, Giovanni ) ) ) [45] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Guarrera, Simonetta ) ) ) [46] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Sacerdote, Carlotta ) ) ) [47] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Wareham, Nicholas J ) ) ) [48] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Langenberg, Claudia ) ) ) [49] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Scott, Robert A ) ) ) [50] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Luan, Jian'an ) ) ) [51] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Bobak, Martin ) ) ) [52] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Malyutina, Sofia ) ) ) [53] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Pająk, Andrzej ) ) ) [54] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Kubinova, Ruzena ) ) ) [55] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Tamosiunas, Abdonas ) ) ) [56] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Pikhart, Hynek ) ) ) [57] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Grarup, Niels ) ) ) [58] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Pedersen, Oluf ) ) ) [59] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hansen, Torben ) ) ) [60] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Linneberg, Allan ) ) ) [61] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Jess, Tine ) ) ) [62] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Cooper, Jackie ) ) ) [63] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Humphries, Steve E ) ) ) [64] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Brilliant, Murray ) ) ) [65] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Kitchner, Terrie ) ) ) [66] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hakonarson, Hakon ) ) ) [67] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Carrell, David S ) ) ) [68] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => McCarty, Catherine A ) ) ) [69] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lester, Kirchner H ) ) ) [70] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Larson, Eric B ) ) ) [71] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Crosslin, David R ) ) ) [72] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => de Andrade, Mariza ) ) ) [73] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Roden, Dan M ) ) ) [74] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Denny, Joshua C ) ) ) [75] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Carty, Cara ) ) ) [76] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hancock, Stephen ) ) ) [77] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Attia, John ) ) ) [78] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Holliday, Elizabeth ) ) ) [79] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Scott, Rodney ) ) ) [80] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Schofield, Peter ) ) ) [81] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => O'Donnell, Martin ) ) ) [82] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Yusuf, Salim ) ) ) [83] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Chong, Michael ) ) ) [84] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Pare, Guillaume ) ) ) [85] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => van der Harst, Pim ) ) ) [86] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Said, M Abdullah ) ) ) [87] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Eppinga, Ruben N ) ) ) [88] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Verweij, Niek ) ) ) [89] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Snieder, Harold ) ) ) [90] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Christen, Tim ) ) ) [91] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Mook-Kanamori, D O ) ) ) [92] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Gustafsson, Stefan ) ) ) [93] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lind, Lars ) ) ) [94] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Ingelsson, Erik ) ) ) [95] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Pazoki, Raha ) ) ) [96] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Franco, Oscar ) ) ) [97] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hofman, Albert ) ) ) [98] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Uitterlinden, Andre ) ) ) [99] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Dehghan, Abbas ) ) ) [100] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Teumer, Alexander ) ) ) [101] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Baumeister, Sebastian ) ) ) [102] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Dörr, Marcus ) ) ) [103] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lerch, Markus M ) ) ) [104] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Völker, Uwe ) ) ) [105] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Völzke, Henry ) ) ) [106] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Ward, Joey ) ) ) [107] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Pell, Jill P ) ) ) [108] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Meade, Tom ) ) ) [109] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Christophersen, Ingrid E ) ) ) [110] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Maitland-van der Zee, Anke H ) ) ) [111] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Baranova, Ekaterina V ) ) ) [112] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Young, Robin ) ) ) [113] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Ford, Ian ) ) ) [114] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Campbell, Archie ) ) ) [115] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Padmanabhan, Sandosh ) ) ) [116] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Bots, Michiel L ) ) ) [117] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Grobbee, Diederick E ) ) ) [118] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Froguel, Philippe ) ) ) [119] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Thuillier, Dorothée ) ) ) [120] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Roussel, Ronan ) ) ) [121] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Bonnefond, Amélie ) ) ) [122] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Cariou, Bertrand ) ) ) [123] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Smart, Melissa ) ) ) [124] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Bao, Yanchun ) ) ) [125] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Kumari, Meena ) ) ) [126] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Mahajan, Anubha ) ) ) [127] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hopewell, Jemma C ) ) ) [128] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Seshadri, Sudha ) ) ) [129] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Dale, Caroline ) ) ) [130] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Costa, Rui Providencia E ) ) ) [131] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Ridker, Paul M ) ) ) [132] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Chasman, Daniel I ) ) ) [133] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Reiner, Alex P ) ) ) [134] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Ritchie, Marylyn D ) ) ) [135] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lange, Leslie A ) ) ) [136] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Cornish, Alex J ) ) ) [137] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Dobbins, Sara E ) ) ) [138] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hemminki, Kari ) ) ) [139] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Kinnersley, Ben ) ) ) [140] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Sanson, Marc ) ) ) [141] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Labreche, Karim ) ) ) [142] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Simon, Matthias ) ) ) [143] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Bondy, Melissa ) ) ) [144] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Law, Philip ) ) ) [145] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Speedy, Helen ) ) ) [146] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Allan, James ) ) ) [147] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Li, Ni ) ) ) [148] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Went, Molly ) ) ) [149] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Weinhold, Niels ) ) ) [150] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Morgan, Gareth ) ) ) [151] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Sonneveld, Pieter ) ) ) [152] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Nilsson, Björn ) ) ) [153] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Goldschmidt, Hartmut ) ) ) [154] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Sud, Amit ) ) ) [155] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Engert, Andreas ) ) ) [156] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hansson, Markus ) ) ) [157] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hemingway, Harry ) ) ) [158] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Asselbergs, Folkert W ) ) ) [159] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Patel, Riyaz S ) ) ) [160] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Keating, Brendan J ) ) ) [161] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Sattar, Naveed ) ) ) [162] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Houlston, Richard ) ) ) [163] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Casas, Juan P ) ) ) [164] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hingorani, Aroon D ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 01 [Type] => published [Y] => 2019 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-locals [Value] => edsbas ) [1] => Array ( [Type] => issn-locals [Value] => edsbas.oa ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => BMC cardiovascular disorders, London : BioMed Central, 2019, vol. 19, no. 1, 240, p. 1-10 ; eISSN 1471-2261 [Type] => main ) ) ) ) ) ) )
IllustrationInfo