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Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study.

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العنوان: Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study.
المؤلفون: Gill, D., Karhunen, V., Malik, R., Dichgans, M., Sofat, N.
المصدر: Osteoarthritis and cartilage 29(3), 365 - 371 (2021). doi:10.1016/j.joca.2020.12.015
بيانات النشر: Elsevier
سنة النشر: 2021
مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Aged, Blood Pressure: genetics, Body Mass Index, Cardiometabolic Risk Factors, Cholesterol, LDL: genetics, Educational Status, Female, Genome-Wide Association Study, Humans, Male, Mediation Analysis, Mendelian Randomization Analysis, Middle Aged, Obesity: epidemiology, Obesity: genetics, Odds Ratio, Osteoarthritis: epidemiology, Osteoarthritis: genetics, Smoking: epidemiology, Smoking: genetics, Cardiometabolic, Education, Mendelian randomization, Osteoarthritis
جغرافية الموضوع: DE
الوصف: To investigate which cardiometabolic factors underlie clustering of osteoarthritis (OA) with cardiovascular disease, and the extent to which these mediate an effect of education.Genome-wide association study (GWAS) of OA was performed in UK Biobank (60,800 cases and 328,251 controls) to obtain genetic association estimates for OA risk. Genetic instruments and association estimates for body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), smoking and education were obtained from existing GWAS summary data (sample sizes 188,577-866,834 individuals). Two-sample Mendelian randomization (MR) analyses were performed to investigate the effects of exposure traits on OA risk. MR mediation analyses were undertaken to investigate whether the cardiometabolic traits mediate any effect of education on OA risk.MR analyses identified protective effects of higher genetically predicted education (main MR analysis odds ratio (OR) per standard deviation increase 0.59, 95% confidence interval (CI) 0.54-0.64) and LDL-C levels (OR 0.94, 95%CI 0.91-0.98) on OA risk, and unfavourable effects of higher genetically predicted BMI (OR 1.82, 95%CI 1.73-1.92) and smoking (OR 2.23, 95%CI 1.85-2.68). There was no strong evidence of an effect of genetically predicted SBP on OA risk (OR 0.98, 95% CI 0.90-1.06). The proportion of the effect of genetically predicted education mediated through genetically predicted BMI and smoking was 35% (95%CI 13-57%).These findings highlight education, obesity and smoking as common mechanisms underlying OA and cardiovascular disease. These risk factors represent clinical and public health targets for reducing multi-morbidity related to the burden these common conditions.
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/issn/1522-9653; info:eu-repo/semantics/altIdentifier/pmid/pmid:33422704; info:eu-repo/semantics/altIdentifier/issn/1063-4584; https://pub.dzne.de/record/155976Test; https://pub.dzne.de/search?p=id:%22DZNE-2021-01108%22Test
الإتاحة: https://doi.org/10.1016/j.joca.2020.12.015Test
https://pub.dzne.de/record/155976Test
https://pub.dzne.de/search?p=id:%22DZNE-2021-01108%22Test
حقوق: info:eu-repo/semantics/closedAccess
رقم الانضمام: edsbas.5C0D7E4D
قاعدة البيانات: BASE
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