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Prolactin response to an acute bromocriptine suppression test (ABST) following surgical debulking of macroprolactinomas

التفاصيل البيبلوغرافية
العنوان: Prolactin response to an acute bromocriptine suppression test (ABST) following surgical debulking of macroprolactinomas
المؤلفون: Lora Stanka Kirigin, Mateja Strinović, Gorana Mirošević, Darko Stipić, Vatroslav Čerina, Jana Ježková, Ludmila Brunerova, Michal Kršek, Milan Vrkljan
المصدر: Endocrine Oncology and Metabolism, Vol 2, Iss 2, Pp 88-93 (2016)
بيانات النشر: VBZ
سنة النشر: 2016
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: acute bromocriptine suppression test, macroprolactinoma, surgical debulking, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Introduction: In centers with tight budgets treating macroprolactinomas with transsphenoidal surgery remains an appealing option because it may increase the efficacy of dopamine agonists (DA) postoperatively. The aim of our study was to determine whether surgical debulking of prolactinomas enhances the response to DA using the results of an acute bromocriptine suppression test (ABST) performed pre and post operatively. Methods: This retrospective case-control study included 12 patients with macroprolactinomas that underwent surgical debulking procedures (9 males; median age: 40 years). ABSTs were performed pre and postoperatively using the following protocol: 1) basal prolactin levels were measured through an indwelling cannula; 2) 2.5 mg of bromocriptine was administered; 3) prolactin levels were measured at hourly intervals for 5 hours after bromocriptine administration. Analyses were performed on log-transformed data. Results: Postoperatively, patients had lower prolactin during the ABST (mean difference- 0.701, 95% CI -1.170 -.231, P=0.005), but without any difference in dynamics of prolactin decrease. Baseline prolactin levels correlated positively with prolactin levels at the end of the bromocriptine test. This was evident prior (ρ=0.715, P=0.009) and after surgery (ρ=0.909, P<0.001, P=0.009). Likewise, there was no correlation between baseline prolactin levels and absolute change in prolactin levels at the end of the bromocriptine test. Conclusion: Prolactin levels decreased significantly during the ABST both pre and postoperatively, but without any difference in dynamics of prolactin decrease. Although our results did not show that surgical debulking enhances the response to DA, further studies are required to determine whether absolute volume reduction affects this relationship.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1849-8922
1849-9031
العلاقة: http://eom.hdeo.eu/wp-content/uploads/2016/07/vol2-iss2-1Kirigin.pdfTest; https://doaj.org/toc/1849-8922Test; https://doaj.org/toc/1849-9031Test; https://doaj.org/article/cd6910fc874046ad97db58e87ff30295Test
DOI: 10.21040/eom/2016.2.2.1
الإتاحة: https://doi.org/10.21040/eom/2016.2.2.1Test
https://doaj.org/article/cd6910fc874046ad97db58e87ff30295Test
رقم الانضمام: edsbas.5414CE25
قاعدة البيانات: BASE
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