دورية أكاديمية
Neurophysiological explorations across the spectrum of psychosis, autism, and depression, during wakefulness and sleep: protocol of a prospective case–control transdiagnostic multimodal study (DEMETER)
العنوان: | Neurophysiological explorations across the spectrum of psychosis, autism, and depression, during wakefulness and sleep: protocol of a prospective case–control transdiagnostic multimodal study (DEMETER) |
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المؤلفون: | Lucarini, Valeria, Alouit, Anaëlle, Yeh, Delphine, Le Coq, Jeanne, Savatte, Romane, Charre, Mylène, Louveau, Cécile, Houamri, Meryem Benlaifa, Penaud, Sylvain, Gaston-Bellegarde, Alexandre, Rio, Stéphane, Drouet, Laurent, Elbaz, Maxime, Becchio, Jean, Pourchet, Sylvain, Pruvost-Robieux, Estelle, Marchi, Angela, Moyal, Mylène, Lefebvre, Aline, Chaumette, Boris, Grice, Martine, Lindberg, Påvel G., Dupin, Lucile, Piolino, Pascale, Lemogne, Cédric, Léger, Damien, Gavaret, Martine, Krebs, Marie-Odile, Iftimovici, Anton |
المساهمون: | Fondation FondaMental - Fondation Bettencourt-Schueller, Agence Nationale de la Recherche, GHU Paris Psychiatrie et Neurosciences |
المصدر: | BMC Psychiatry ; volume 23, issue 1 ; ISSN 1471-244X |
بيانات النشر: | Springer Science and Business Media LLC |
سنة النشر: | 2023 |
مصطلحات موضوعية: | Psychiatry and Mental health |
الوصف: | Background Quantitative electroencephalography (EEG) analysis offers the opportunity to study high-level cognitive processes across psychiatric disorders. In particular, EEG microstates translate the temporal dynamics of neuronal networks throughout the brain. Their alteration may reflect transdiagnostic anomalies in neurophysiological functions that are impaired in mood, psychosis, and autism spectrum disorders, such as sensorimotor integration, speech, sleep, and sense of self. The main questions this study aims to answer are as follows: 1) Are EEG microstate anomalies associated with clinical and functional prognosis, both in resting conditions and during sleep, across psychiatric disorders? 2) Are EEG microstate anomalies associated with differences in sensorimotor integration, speech, sense of self, and sleep? 3) Can the dynamic of EEG microstates be modulated by a non-drug intervention such as light hypnosis? Methods This prospective cohort will include a population of adolescents and young adults, aged 15 to 30 years old, with ultra-high-risk of psychosis (UHR), first-episode psychosis (FEP), schizophrenia (SCZ), autism spectrum disorder (ASD), and major depressive disorder (MDD), as well as healthy controls (CTRL) ( N = 21 × 6), who will be assessed at baseline and after one year of follow-up. Participants will undergo deep phenotyping based on psychopathology, neuropsychological assessments, 64-channel EEG recordings, and biological sampling at the two timepoints. At baseline, the EEG recording will also be coupled to a sensorimotor task and a recording of the characteristics of their speech (prosody and turn-taking), a one-night polysomnography, a self-reference effect task in virtual reality (only in UHR, FEP, and CTRL). An interventional ancillary study will involve only healthy controls, in order to assess whether light hypnosis can modify the EEG microstate architecture in a direction opposite to what is seen in disease. Discussion This transdiagnostic longitudinal case–control study will ... |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
DOI: | 10.1186/s12888-023-05347-x |
DOI: | 10.1186/s12888-023-05347-x.pdf |
DOI: | 10.1186/s12888-023-05347-x/fulltext.html |
الإتاحة: | https://doi.org/10.1186/s12888-023-05347-xTest |
حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
رقم الانضمام: | edsbas.4F8F14DF |
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