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Intermittently Scanned Continuous Glucose Monitoring for Type 1 Diabetes

التفاصيل البيبلوغرافية
العنوان: Intermittently Scanned Continuous Glucose Monitoring for Type 1 Diabetes
المؤلفون: Evans, Mark, Leelarathna, Lalantha, Sankalpa, Neupane, Gerry, Rayman, Sarah, Lumley, Iain, Cranston, Parth, Narendran, Katherine, Barnard-Kelly, Christopher, Sutton, Rachel, Elliott, Vicky, Taxiarchi, Georgios, Gkountouras, Matthew, Burns, Womba, Mubita, Naresh, Kanumilli, Maisie, Camm, Hood, Thabit, Emma, Wilmot
بيانات النشر: Massachusetts Medical Society
Department of Medicine
//dx.doi.org/10.1056/nejmoa2205650
New England Journal of Medicine
سنة النشر: 2022
المجموعة: Apollo - University of Cambridge Repository
مصطلحات موضوعية: Adult, Female, Humans, Male, Middle Aged, Blood Glucose, Blood Glucose Self-Monitoring, Diabetes Mellitus, Type 1, Glycated Hemoglobin, Hypoglycemia, Hypoglycemic Agents, Insulin
الوصف: Background The benefits of intermittently-scanned continuous glucose monitoring with optional alarms (isCGM) for people with Type 1 diabetes (T1D) and high glycated hemoglobin levels are unknown. Methods In this multicenter, parallel-design, randomized controlled trial, 156 people with T1D and glycated hemoglobin values between 7.5% and 11.0% with mean (SD) age 43.5 (14.9) years, diabetes duration 21.1 (12.6) years, 44% women, were allocated (1:1) to isCGM (n=78) or self-monitoring of blood glucose with finger sticks (SMBG, n=78). The primary outcome was glycated hemoglobin at 24 weeks analyzed according to ‘intention to treat.’ Key secondary outcomes were sensor metrics, participant-reported outcome measures, and safety. Results The mean (SD) baseline glycated hemoglobin (%) was 8.7 (0.9) in the isCGM group and 8.5 (0.8) in the SMBG group, decreased to 7.9 (0.8) vs. 8.3 (0.9), respectively, at 24 weeks (adjusted mean difference -0.5, 95% confidence interval [CI] -0.7 to -0.3; p<0.001]. The time per day with the glucose level in the target range was 9.0 (95% CI 4.7 to 13.3) percentage points or 130 (95% CI 68 to 192) minutes higher, the time spent in hypoglycemia (<70mg/dl) was 3.0 (95% CI 1.4 to 4.5) percentage points or 43 (95% CI 20 to 65) minutes lower. The Diabetes Treatment Satisfaction Questionnaire score was 7.0 (95% CI 5.2 to 8.7) points higher in the isCGM group. Two participants experienced severe hypoglycemia in the SMBG group while one participant in the isCGM group experienced skin reaction to sensor. Conclusions Among adults with T1D and high glycated hemoglobin levels, use of isCGM with optional alarms resulted in significantly lower glycated hemoglobin levels as compared with SMBG. ; Diabetes UK grant number 18/0005836 NIHR Cambridge Biomedical Research Centre
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/octet-stream
اللغة: English
العلاقة: https://www.repository.cam.ac.uk/handle/1810/343401Test
DOI: 10.17863/CAM.90824
الإتاحة: https://doi.org/10.17863/CAM.90824Test
https://www.repository.cam.ac.uk/handle/1810/343401Test
حقوق: Attribution-NoDerivatives 4.0 International ; https://creativecommons.org/licenses/by-nd/4.0Test/
رقم الانضمام: edsbas.4C02280D
قاعدة البيانات: BASE
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