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Human N-acetyltransferase 2 (NAT2) gene variability in Brazilian populations from different geographical areas

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العنوان: Human N-acetyltransferase 2 (NAT2) gene variability in Brazilian populations from different geographical areas
المؤلفون: Márcia Quinhones P. Lopes, Raquel Lima F. Teixeira, Pedro Hernan Cabello, José Augusto C. Nery, Anna Maria Sales, Edilbert Pellegrini Nahn J. R., Marilda Vieira Moreira, Ewalda Von Rosen Stahlke, Lia Gonçalves Possuelo, Maria Lucia R. Rossetti, Marcelo F. Rabahi, Luciana F. M. Silva, Patrícia Almeida Leme, William John Woods, Mauricio Lisboa Nobre, Maria Leide Wan-Del-Rey de Oliveira, Kazuê Narahashi, Milde Cavalcanti, Philip Noel Suffys, Sotiria Boukouvala, Maria Eugênia N. Gallo, Adalberto Rezende Santos
المصدر: Frontiers in Pharmacology, Vol 14 (2023)
بيانات النشر: Frontiers Media S.A.
سنة النشر: 2023
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: human NAT2, N-acetyltransferase 2, polymorphisms, admixed population, sequencing, Therapeutics. Pharmacology, RM1-950
الوصف: Introduction: Several polymorphisms altering the NAT2 activity have already been identified. The geographical distribution of NAT2 variants has been extensively studied and has been demonstrated to vary significantly among different ethnic population. Here, we describe the genetic variability of human N-acetyltransferase 2 (NAT2) gene and the predominant genotype-deduced acetylation profiles of Brazilians.Methods: A total of 964 individuals, from five geographical different regions, were genotyped for NAT2 by sequencing the entire coding exon.Results: Twenty-three previously described NAT2 single nucleotide polymorphisms (SNPs) were identified, including the seven most common ones globally (c.191G>A, c.282C>T, c.341T>C, c.481C>T, c.590G>A, c.803A>G and c.857G>A). The main allelic groups were NAT2*5 (36%) and NAT2*6 (18.2%), followed to the reference allele NAT2*4 (20.4%). Combined into genotypes, the most prevalent allelic groups were NAT2*5/*5 (14.6%), NAT2*5/*6 (11.9%) and NAT2*6/*6 (6.2%). The genotype deduced NAT2 slow acetylation phenotype was predominant but showed significant variability between geographical regions. The prevalence of slow acetylation phenotype was higher in the Northeast, North and Midwest (51.3%, 45.5% and 41.5%, respectively) of the country. In the Southeast, the intermediate acetylation phenotype was the most prevalent (40.3%) and, in the South, the prevalence of rapid acetylation phenotype was significantly higher (36.7%), when compared to other Brazilian states (p < 0.0001). Comparison of the predicted acetylation profile among regions showed homogeneity among the North and Northeast but was significantly different when compared to the Southeast (p = 0.0396). The Southern region was significantly different from all other regions (p < 0.0001).Discussion: This study contributes not only to current knowledge of the NAT2 population genetic diversity in different geographical regions of Brazil, but also to the reconstruction of a more accurate phenotypic ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1663-9812
العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2023.1278720/fullTest; https://doaj.org/toc/1663-9812Test; https://doaj.org/article/eb92ce59510f48f8a05329b36d2ff020Test
DOI: 10.3389/fphar.2023.1278720
الإتاحة: https://doi.org/10.3389/fphar.2023.1278720Test
https://doaj.org/article/eb92ce59510f48f8a05329b36d2ff020Test
رقم الانضمام: edsbas.491A1F0A
قاعدة البيانات: BASE
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