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Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer.

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العنوان: Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer.
المؤلفون: Joanito, I., Wirapati, P., Zhao, N., Nawaz, Z., Yeo, G., Lee, F., Eng, CLP, Macalinao, D.C., Kahraman, M., Srinivasan, H., Lakshmanan, V., Verbandt, S., Tsantoulis, P., Gunn, N., Venkatesh, P.N., Poh, Z.W., Nahar, R., Oh, HLJ, Loo, J.M., Chia, S., Cheow, L.F., Cheruba, E., Wong, M.T., Kua, L., Chua, C., Nguyen, A., Golovan, J., Gan, A., Lim, W.J., Guo, Y.A., Yap, C.K., Tay, B., Hong, Y., Chong, D.Q., Chok, A.Y., Park, W.Y., Han, S., Chang, M.H., Seow-En, I., Fu, C., Mathew, R., Toh, E.L., Hong, L.Z., Skanderup, A.J., DasGupta, R., Ong, C.J., Lim, K.H., Tan, EKW, Koo, S.L., Leow, W.Q., Tejpar, S., Prabhakar, S., Tan, I.B.
المصدر: Nature genetics, vol. 54, no. 7, pp. 963-975
سنة النشر: 2022
المجموعة: Université de Lausanne (UNIL): Serval - Serveur académique lausannois
مصطلحات موضوعية: Colorectal Neoplasms/genetics, Colorectal Neoplasms/pathology, Epithelial Cells/pathology, Humans, Microsatellite Instability, Microsatellite Repeats/genetics, Neoplasms, Glandular and Epithelial/genetics, Transcriptome/genetics
الوصف: The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed 373,058 single-cell transcriptomes from 63 patients, focusing on 49,155 epithelial cells. We identified a pervasive genetic and transcriptomic dichotomy of malignant cells, based on distinct gene expression, DNA copy number and gene regulatory network. We recapitulated these subtypes in bulk transcriptomes from 3,614 patients. The two intrinsic subtypes, iCMS2 and iCMS3, refine CMS. iCMS3 comprises microsatellite unstable (MSI-H) cancers and one-third of microsatellite-stable (MSS) tumors. iCMS3 MSS cancers are transcriptomically more similar to MSI-H cancers than to other MSS cancers. CMS4 cancers had either iCMS2 or iCMS3 epithelium; the latter had the worst prognosis. We defined the intrinsic epithelial axis of colorectal cancer and propose a refined 'IMF' classification with five subtypes, combining intrinsic epithelial subtype (I), microsatellite instability status (M) and fibrosis (F).
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 1061-4036
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35773407; info:eu-repo/semantics/altIdentifier/eissn/1546-1718; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_27A9BBA898C96; https://serval.unil.ch/notice/serval:BIB_27A9BBA898C9Test; urn:issn:1061-4036; https://serval.unil.ch/resource/serval:BIB_27A9BBA898C9.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_27A9BBA898C96Test
DOI: 10.1038/s41588-022-01100-4
الإتاحة: https://doi.org/10.1038/s41588-022-01100-4Test
https://serval.unil.ch/notice/serval:BIB_27A9BBA898C9Test
https://serval.unil.ch/resource/serval:BIB_27A9BBA898C9.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_27A9BBA898C96Test
حقوق: info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0Test/
رقم الانضمام: edsbas.455B20A2
قاعدة البيانات: BASE
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