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Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019

التفاصيل البيبلوغرافية
العنوان: Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019
المؤلفون: Rubin, Sebastien, Orieux, Arthur, Prevel, Renaud, Garric, Antoine, Bats, Marie-Lise, Dabernat, Sandrine, Camou, Fabrice, Guisset, Olivier, Issa, Nahema, Mourissoux, Gaelle, Dewitte, Antoine, Joannes-Boyau, Olivier, Fleureau, Catherine, Rozé, Hadrien, Carrié, Cédric, Petit, Laurent, Clouzeau, Benjamin, Sazio, Charline, Bui, Hoang-Nam, Pillet, Odile, Rigothier, Claire, Vargas, Frederic, Combe, Christian, Gruson, Didier, Boyer, Alexandre
المساهمون: Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases, Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Pellegrin, CHU Bordeaux-Groupe hospitalier Pellegrin, CHU Bordeaux
المصدر: ISSN: 2048-8505.
بيانات النشر: HAL CCSD
Oxford University Press
سنة النشر: 2020
المجموعة: Inserm: HAL (Institut national de la santé et de la recherche médicale)
مصطلحات موضوعية: acute interstitial nephritis, acute kidney injury, acute tubular injury, COVID-19, critically ill patients, renal replacement therapy, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
الوصف: International audience ; Abstract Background Coronavirus disease 2019 (COVID-19)-associated acute kidney injury (AKI) frequency, severity and characterization in critically ill patients has not been reported.Methods Single-centre cohort performed from 3 March 2020 to 14 April 2020 in four intensive care units in Bordeaux University Hospital, France. All patients with COVID-19 and pulmonary severity criteria were included. AKI was defined using Kidney Disease: Improving Global Outcomes (KDIGO) criteria. A systematic urinary analysis was performed. The incidence, severity, clinical presentation, biological characterization (transient versus persistent AKI; proteinuria, haematuria and glycosuria) and short-term outcomes were evaluated.Results Seventy-one patients were included, with basal serum creatinine (SCr) of 69 ± 21 µmol/L. At admission, AKI was present in 8/71 (11%) patients. Median [interquartile range (IQR)] follow-up was 17 (12–23) days. AKI developed in a total of 57/71 (80%) patients, with 35% Stage 1, 35% Stage 2 and 30% Stage 3 AKI; 10/57 (18%) required renal replacement therapy (RRT). Transient AKI was present in only 4/55 (7%) patients and persistent AKI was observed in 51/55 (93%). Patients with persistent AKI developed a median (IQR) urine protein/creatinine of 82 (54–140) (mg/mmol) with an albuminuria/proteinuria ratio of 0.23 ± 20, indicating predominant tubulointerstitial injury. Only two (4%) patients had glycosuria. At Day 7 after onset of AKI, six (11%) patients remained dependent on RRT, nine (16%) had SCr >200 µmol/L and four (7%) had died. Day 7 and Day 14 renal recovery occurred in 28% and 52%, respectively.Conclusion Severe COVID-19-associated AKI is frequent, persistent, severe and characterized by an almost exclusive tubulointerstitial injury without glycosuria.
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: hal-03194408; https://hal.science/hal-03194408Test; https://hal.science/hal-03194408/documentTest; https://hal.science/hal-03194408/file/BMC_ClinKidneyJ_2020_Rubin.pdfTest
DOI: 10.1093/ckj/sfaa099
الإتاحة: https://doi.org/10.1093/ckj/sfaa099Test
https://hal.science/hal-03194408Test
https://hal.science/hal-03194408/documentTest
https://hal.science/hal-03194408/file/BMC_ClinKidneyJ_2020_Rubin.pdfTest
حقوق: http://creativecommons.org/licenses/by-ncTest/ ; info:eu-repo/semantics/OpenAccess
رقم الانضمام: edsbas.2DFB9C80
قاعدة البيانات: BASE
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