دورية أكاديمية
Phencyclidine and related compounds evoke [ 3 H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site
| العنوان: | Phencyclidine and related compounds evoke [ 3 H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site |
|---|---|
| المؤلفون: | Mount, Howard, Boksa, Patricia, Chaudieu, Isabelle, Quirion, Rémi |
| المصدر: | Canadian Journal of Physiology and Pharmacology ; volume 68, issue 9, page 1200-1206 ; ISSN 0008-4212 1205-7541 |
| بيانات النشر: | Canadian Science Publishing |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Physiology (medical), Pharmacology, General Medicine, Physiology |
| الوصف: | At concentrations ≥100 μM, phencyclidine (PCP), N-(1-(2-thienyl)-cyclohexyl)piperidine (TCP), and MK-801 induced [ 3 H]dopamine release from dissociated cell cultures of rat mesencephalon. This release was Ca 2+ independent and tetrodotoxin insensitive. Tetrodotoxin (2 μM) itself had no effect on spontaneous release of [ 3 H]dopamine. [ 3 H]Dopamine release was induced by 1,3-di(2-tolyl)guanidine, a sigma ligand, and by 4-aminopyridine (1–3 mM), a K + channel blocker. No stereoselectivity was observed for [ 3 H]dopamine release evoked by the dioxadrol enantiomers, dexoxadrol, and levoxadrol, or by enantiomers of N-allylnormetazocine (SKF 10,047). The selective dopamine uptake inhibitor 1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (GBR 12909) did not affect spontaneous or TCP-evoked [ 3 H]dopamine release. Together, these data suggest that the dopamine-releasing effects of PCP-like compounds on the mesencephalic cells were not mediated by actions at the PCP receptor or sigma binding site, Ca 2+ , or Na + channels, or at the high affinity dopamine uptake site. It remains conceivable that blocking actions of PCP-like compounds at voltage-regulated K + channels may at least partly explain the response. These results are discussed in comparison with findings in intact brain.Key words: dopamine, phencyclidine, cell culture, mesencephalon. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1139/y90-180 |
| الإتاحة: | https://doi.org/10.1139/y90-180Test |
| حقوق: | http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMiningTest |
| رقم الانضمام: | edsbas.2BDB1DC2 |
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