دورية أكاديمية
أعرض في EDS

The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis

التفاصيل البيبلوغرافية
العنوان: The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis
المؤلفون: Brown, Matthew A., Kennedy, L. G., Darke, C., Gibson, K., Pile, K. D., Shatford, J. L., Taylor, A., Calin, A., Wordsworth, B. P.
المصدر: Arthritis and Rheumatism
بيانات النشر: John Wiley & Sons
سنة النشر: 1998
المجموعة: Queensland University of Technology: QUT ePrints
مصطلحات موضوعية: HLA antigen class 1, HLA DR antigen, adult, aged, ankylosing spondylitis, article, bone marrow cell, disease severity, drug effect, female, gene linkage disequilibrium, genetic susceptibility, HLA typing, human, major clinical study, male, priority journal, restriction fragment length polymorphism, Age of Onset, Arthritis, Genetic Predisposition to Disease, Heterozygote, HLA-DR Antigens, Homozygote, Humans, Risk Factors, Spondylitis, Ankylosing
الوصف: Objective. To analyze the effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis (AS). Methods. Three hundred sixty- three white British AS patients were studied; 149 were carefully assessed for a range of clinical manifestations, and disease severity was assessed using a structured questionnaire. Limited HLA class I typing and complete HLA-DR typing were performed using DNA-based methods. HLA data from 13,634 healthy white British bone marrow donors were used for comparison. Results. A significant association between DR1 and AS was found, independent of HLA-B27 (overall odds ratio [OR] 1.4, 95% confidence interval [95% CI] 1.1-1.8, P = 0.02; relative risk [RR] 2.7, 95% CI 1.5-4.8, P = 6 x 10-4 among homozygotes; RR 2.1, 95% CI 1.5-2.8, P = 5 x 10-6 among heterozygotes). A large but weakly significant association between DR8 and AS was noted, particularly among DR8 homozygotes (RR 6.8, 95% CI 1.6-29.2, P = 0.01 among homozygotes; RR 1.6, 95% CI 1.0-2.7, P = 0.07 among heterozygotes). A negative association with DR12 (OR 0.22, 95% CI 0.09-0.5, P = 0.001) was noted. HLA-DR7 was associated with younger age at onset of disease (mean age at onset 18 years for DR7-positive patients and 23 years for DR7-negative patients; Z score 3.21, P = 0.001). No other HLA class I or class H associations with disease severity or with different clinical manifestations of AS were found. Conclusion. The results of this study suggest that HLA-DR genes may have a weak effect on susceptibility to AS independent of HLA-B27, but do not support suggestions that they affect disease severity or different clinical manifestations.
نوع الوثيقة: article in journal/newspaper
اللغة: unknown
العلاقة: Brown, Matthew A., Kennedy, L. G., Darke, C., Gibson, K., Pile, K. D., Shatford, J. L., Taylor, A., Calin, A., & Wordsworth, B. P. (1998) The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis. Arthritis and Rheumatism, 41(3), pp. 460-465.; https://eprints.qut.edu.au/87767Test/; Institute of Health and Biomedical Innovation
الإتاحة: https://doi.org/10.1002/1529-0131Test(199803)41:3<460::AID-ART12>3.0.CO;2-X
https://eprints.qut.edu.au/87767Test/
حقوق: Consult author(s) regarding copyright matters ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au
رقم الانضمام: edsbas.2753AF93
قاعدة البيانات: BASE
ResultId 1
Header edsbas
BASE
edsbas.2753AF93
754
3
Academic Journal
academicJournal
753.78955078125
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.2753AF93&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://doi.org/10.1002/1529-0131(199803)41:3<460::AID-ART12>3.0.CO;2-X# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Brown%2C+Matthew+A%2E%22&quot;&gt;Brown, Matthew A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kennedy%2C+L%2E+G%2E%22&quot;&gt;Kennedy, L. G.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Darke%2C+C%2E%22&quot;&gt;Darke, C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gibson%2C+K%2E%22&quot;&gt;Gibson, K.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pile%2C+K%2E+D%2E%22&quot;&gt;Pile, K. D.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shatford%2C+J%2E+L%2E%22&quot;&gt;Shatford, J. L.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Taylor%2C+A%2E%22&quot;&gt;Taylor, A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Calin%2C+A%2E%22&quot;&gt;Calin, A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wordsworth%2C+B%2E+P%2E%22&quot;&gt;Wordsworth, B. P.&lt;/searchLink&gt; )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Arthritis and Rheumatism )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => John Wiley &amp; Sons )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 1998 )
Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => Queensland University of Technology: QUT ePrints )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22HLA+antigen+class+1%22&quot;&gt;HLA antigen class 1&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22HLA+DR+antigen%22&quot;&gt;HLA DR antigen&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22adult%22&quot;&gt;adult&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22aged%22&quot;&gt;aged&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ankylosing+spondylitis%22&quot;&gt;ankylosing spondylitis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22article%22&quot;&gt;article&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22bone+marrow+cell%22&quot;&gt;bone marrow cell&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22disease+severity%22&quot;&gt;disease severity&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22drug+effect%22&quot;&gt;drug effect&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22female%22&quot;&gt;female&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22gene+linkage+disequilibrium%22&quot;&gt;gene linkage disequilibrium&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22genetic+susceptibility%22&quot;&gt;genetic susceptibility&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22HLA+typing%22&quot;&gt;HLA typing&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22human%22&quot;&gt;human&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22major+clinical+study%22&quot;&gt;major clinical study&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22male%22&quot;&gt;male&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22priority+journal%22&quot;&gt;priority journal&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22restriction+fragment+length+polymorphism%22&quot;&gt;restriction fragment length polymorphism&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Age+of+Onset%22&quot;&gt;Age of Onset&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Arthritis%22&quot;&gt;Arthritis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Genetic+Predisposition+to+Disease%22&quot;&gt;Genetic Predisposition to Disease&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Heterozygote%22&quot;&gt;Heterozygote&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22HLA-DR+Antigens%22&quot;&gt;HLA-DR Antigens&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Homozygote%22&quot;&gt;Homozygote&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Risk+Factors%22&quot;&gt;Risk Factors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Spondylitis%22&quot;&gt;Spondylitis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Ankylosing%22&quot;&gt;Ankylosing&lt;/searchLink&gt; )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Objective. To analyze the effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis (AS). Methods. Three hundred sixty- three white British AS patients were studied; 149 were carefully assessed for a range of clinical manifestations, and disease severity was assessed using a structured questionnaire. Limited HLA class I typing and complete HLA-DR typing were performed using DNA-based methods. HLA data from 13,634 healthy white British bone marrow donors were used for comparison. Results. A significant association between DR1 and AS was found, independent of HLA-B27 (overall odds ratio [OR] 1.4, 95% confidence interval [95% CI] 1.1-1.8, P = 0.02; relative risk [RR] 2.7, 95% CI 1.5-4.8, P = 6 x 10-4 among homozygotes; RR 2.1, 95% CI 1.5-2.8, P = 5 x 10-6 among heterozygotes). A large but weakly significant association between DR8 and AS was noted, particularly among DR8 homozygotes (RR 6.8, 95% CI 1.6-29.2, P = 0.01 among homozygotes; RR 1.6, 95% CI 1.0-2.7, P = 0.07 among heterozygotes). A negative association with DR12 (OR 0.22, 95% CI 0.09-0.5, P = 0.001) was noted. HLA-DR7 was associated with younger age at onset of disease (mean age at onset 18 years for DR7-positive patients and 23 years for DR7-negative patients; Z score 3.21, P = 0.001). No other HLA class I or class H associations with disease severity or with different clinical manifestations of AS were found. Conclusion. The results of this study suggest that HLA-DR genes may have a weak effect on susceptibility to AS independent of HLA-B27, but do not support suggestions that they affect disease severity or different clinical manifestations. )
Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper )
Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => unknown )
Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => Brown, Matthew A., Kennedy, L. G., Darke, C., Gibson, K., Pile, K. D., Shatford, J. L., Taylor, A., Calin, A., &amp; Wordsworth, B. P. (1998) The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis. Arthritis and Rheumatism, 41(3), pp. 460-465.; https://eprints.qut.edu.au/87767/; Institute of Health and Biomedical Innovation )
Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://doi.org/10.1002/1529-0131(199803)41:3&lt;460::AID-ART12&gt;3.0.CO;2-X&lt;br /&gt;https://eprints.qut.edu.au/87767/ )
Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => Consult author(s) regarding copyright matters ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.2753AF93 )
RecordInfo Array ( [BibEntity] => Array ( [Languages] => Array ( [0] => Array ( [Text] => unknown ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => HLA antigen class 1 [Type] => general ) [1] => Array ( [SubjectFull] => HLA DR antigen [Type] => general ) [2] => Array ( [SubjectFull] => adult [Type] => general ) [3] => Array ( [SubjectFull] => aged [Type] => general ) [4] => Array ( [SubjectFull] => ankylosing spondylitis [Type] => general ) [5] => Array ( [SubjectFull] => article [Type] => general ) [6] => Array ( [SubjectFull] => bone marrow cell [Type] => general ) [7] => Array ( [SubjectFull] => disease severity [Type] => general ) [8] => Array ( [SubjectFull] => drug effect [Type] => general ) [9] => Array ( [SubjectFull] => female [Type] => general ) [10] => Array ( [SubjectFull] => gene linkage disequilibrium [Type] => general ) [11] => Array ( [SubjectFull] => genetic susceptibility [Type] => general ) [12] => Array ( [SubjectFull] => HLA typing [Type] => general ) [13] => Array ( [SubjectFull] => human [Type] => general ) [14] => Array ( [SubjectFull] => major clinical study [Type] => general ) [15] => Array ( [SubjectFull] => male [Type] => general ) [16] => Array ( [SubjectFull] => priority journal [Type] => general ) [17] => Array ( [SubjectFull] => restriction fragment length polymorphism [Type] => general ) [18] => Array ( [SubjectFull] => Age of Onset [Type] => general ) [19] => Array ( [SubjectFull] => Arthritis [Type] => general ) [20] => Array ( [SubjectFull] => Genetic Predisposition to Disease [Type] => general ) [21] => Array ( [SubjectFull] => Heterozygote [Type] => general ) [22] => Array ( [SubjectFull] => HLA-DR Antigens [Type] => general ) [23] => Array ( [SubjectFull] => Homozygote [Type] => general ) [24] => Array ( [SubjectFull] => Humans [Type] => general ) [25] => Array ( [SubjectFull] => Risk Factors [Type] => general ) [26] => Array ( [SubjectFull] => Spondylitis [Type] => general ) [27] => Array ( [SubjectFull] => Ankylosing [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Brown, Matthew A. ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Kennedy, L. G. ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Darke, C. ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Gibson, K. ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Pile, K. D. ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Shatford, J. L. ) ) ) [6] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Taylor, A. ) ) ) [7] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Calin, A. ) ) ) [8] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Wordsworth, B. P. ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 01 [Type] => published [Y] => 1998 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-locals [Value] => edsbas ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Arthritis and Rheumatism [Type] => main ) ) ) ) ) ) )
IllustrationInfo