دورية أكاديمية
أعرض في EDS

Pro-inflammatory biomarkers during experimental gingivitis in patients with type 1 diabetes mellitus: A proof-of-concept study

التفاصيل البيبلوغرافية
العنوان: Pro-inflammatory biomarkers during experimental gingivitis in patients with type 1 diabetes mellitus: A proof-of-concept study
المؤلفون: Salvi, GE, Giannobile, WV, Lee, A, Rutger Persson, G, Franco, LM, Braun, TM, Lang, NP
بيانات النشر: //www.blackwellpublishing.com/journals/CPE
Denmark
سنة النشر: 2010
المجموعة: University of Hong Kong: HKU Scholars Hub
مصطلحات موضوعية: Periodontal Index, Nucleic Acid Hybridization, Matrix Metalloproteinase 9 - analysis, Matrix Metalloproteinase 8 - analysis, Interleukin-8 - analysis, Gingival Crevicular Fluid - chemistry, Gingivitis - metabolism, Case-Control Studies, Cohort Studies, Adolescent, Adult, Bacteria - classification, Biofilms, Biological Markers - analysis, Dental Plaque - microbiology, Humans, Interleukin-1beta - analysis, Inflammation Mediators - analysis, Dental Plaque Index, Diabetes Mellitus, Type 1 - complications - metabolism, Young Adult, Prospective Studies, Follow-Up Studies
الوصف: Aim: To compare gingival crevicular fluid (GCF) biomarker levels and microbial distribution in plaque biofilm (SP) samples for subjects with type 1 diabetes (T1DM) versus healthy subjects without diabetes during experimental gingivitis (EG). Materials and Methods: A total of nine T1DM patients and nine healthy controls of age and gender similar to the T1DM patients were monitored for 35 days during EG. Hygiene practices were stopped for 3 weeks, and GCF, SP, plaque index (PI) and gingival index were determined. IL-1β, IL-8, MMP-8 and MMP-9 were quantified by enzyme-linked immunosorbent assay, and SP samples were assessed by DNA-DNA hybridization for a panel of 40 subgingival microbial species. Results: IL-1β levels in T1DM patients were elevated compared with healthy individuals, and showed differences between groups at 7-21 days while healthy patients showed IL-1β increases from baseline to 14-21 days (p<0.05). Differences were observed in MMP-9 levels between patients with and without T1DM at 7-14 days (p<0.05). Orange complex species and PI measurements displayed a superior correlation with biomarker levels when compared with other complexes or clinical measurements during EG. Conclusions: The mean GCF biomarker levels for IL-1β and MMP-8 were most significantly elevated in T1DM subjects compared with healthy individuals during EG, not resulting from differences in the mean PI or microbial composition. © 2009 John Wiley & Sons A/S. ; link_to_subscribed_fulltext
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 0303-6979
العلاقة: Journal of Clinical Periodontology; http://www.scopus.com/mlt/select.url?eid=2-s2.0-72549107943&selection=ref&src=s&origin=recordpageTest; Journal Of Clinical Periodontology, 2010, v. 37 n. 1, p. 9-16; 6466146; 16; 169087; WOS:000272771700002; http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0303-6979&volume=37&spage=9&epage=16&date=2010&atitle=Pro-inflammatory+biomarkers+during+experimental+gingivitis+in+patients+with+type+1+diabetes+mellitus:+a+proof-of-concept+studyTest; eid_2-s2.0-72549107943; http://hdl.handle.net/10722/66053Test; 37
DOI: 10.1111/j.1600-051X.2009.01500.x
الإتاحة: https://doi.org/10.1111/j.1600-051X.2009.01500.xTest
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0303-6979&volume=37&spage=9&epage=16&date=2010&atitle=Pro-inflammatory+biomarkers+during+experimental+gingivitis+in+patients+with+type+1+diabetes+mellitus:+a+proof-of-concept+studyTest
http://hdl.handle.net/10722/66053Test
رقم الانضمام: edsbas.1D1DED08
قاعدة البيانات: BASE
ResultId 1
Header edsbas
BASE
edsbas.1D1DED08
771
3
Academic Journal
academicJournal
771.324340820313
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.1D1DED08&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://doi.org/10.1111/j.1600-051X.2009.01500.x# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Pro-inflammatory biomarkers during experimental gingivitis in patients with type 1 diabetes mellitus: A proof-of-concept study )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Salvi%2C+GE%22&quot;&gt;Salvi, GE&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Giannobile%2C+WV%22&quot;&gt;Giannobile, WV&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lee%2C+A%22&quot;&gt;Lee, A&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rutger+Persson%2C+G%22&quot;&gt;Rutger Persson, G&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Franco%2C+LM%22&quot;&gt;Franco, LM&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Braun%2C+TM%22&quot;&gt;Braun, TM&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lang%2C+NP%22&quot;&gt;Lang, NP&lt;/searchLink&gt; )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => //www.blackwellpublishing.com/journals/CPE&lt;br /&gt;Denmark )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2010 )
Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => University of Hong Kong: HKU Scholars Hub )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Periodontal+Index%22&quot;&gt;Periodontal Index&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Nucleic+Acid+Hybridization%22&quot;&gt;Nucleic Acid Hybridization&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Matrix+Metalloproteinase+9+-+analysis%22&quot;&gt;Matrix Metalloproteinase 9 - analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Matrix+Metalloproteinase+8+-+analysis%22&quot;&gt;Matrix Metalloproteinase 8 - analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Interleukin-8+-+analysis%22&quot;&gt;Interleukin-8 - analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Gingival+Crevicular+Fluid+-+chemistry%22&quot;&gt;Gingival Crevicular Fluid - chemistry&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Gingivitis+-+metabolism%22&quot;&gt;Gingivitis - metabolism&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Case-Control+Studies%22&quot;&gt;Case-Control Studies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cohort+Studies%22&quot;&gt;Cohort Studies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Adolescent%22&quot;&gt;Adolescent&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Adult%22&quot;&gt;Adult&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bacteria+-+classification%22&quot;&gt;Bacteria - classification&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Biofilms%22&quot;&gt;Biofilms&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Biological+Markers+-+analysis%22&quot;&gt;Biological Markers - analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Dental+Plaque+-+microbiology%22&quot;&gt;Dental Plaque - microbiology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Interleukin-1beta+-+analysis%22&quot;&gt;Interleukin-1beta - analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Inflammation+Mediators+-+analysis%22&quot;&gt;Inflammation Mediators - analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Dental+Plaque+Index%22&quot;&gt;Dental Plaque Index&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Diabetes+Mellitus%22&quot;&gt;Diabetes Mellitus&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Type+1+-+complications+-+metabolism%22&quot;&gt;Type 1 - complications - metabolism&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Young+Adult%22&quot;&gt;Young Adult&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Prospective+Studies%22&quot;&gt;Prospective Studies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Follow-Up+Studies%22&quot;&gt;Follow-Up Studies&lt;/searchLink&gt; )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Aim: To compare gingival crevicular fluid (GCF) biomarker levels and microbial distribution in plaque biofilm (SP) samples for subjects with type 1 diabetes (T1DM) versus healthy subjects without diabetes during experimental gingivitis (EG). Materials and Methods: A total of nine T1DM patients and nine healthy controls of age and gender similar to the T1DM patients were monitored for 35 days during EG. Hygiene practices were stopped for 3 weeks, and GCF, SP, plaque index (PI) and gingival index were determined. IL-1β, IL-8, MMP-8 and MMP-9 were quantified by enzyme-linked immunosorbent assay, and SP samples were assessed by DNA-DNA hybridization for a panel of 40 subgingival microbial species. Results: IL-1β levels in T1DM patients were elevated compared with healthy individuals, and showed differences between groups at 7-21 days while healthy patients showed IL-1β increases from baseline to 14-21 days (p&lt;0.05). Differences were observed in MMP-9 levels between patients with and without T1DM at 7-14 days (p&lt;0.05). Orange complex species and PI measurements displayed a superior correlation with biomarker levels when compared with other complexes or clinical measurements during EG. Conclusions: The mean GCF biomarker levels for IL-1β and MMP-8 were most significantly elevated in T1DM subjects compared with healthy individuals during EG, not resulting from differences in the mean PI or microbial composition. &#169; 2009 John Wiley &amp; Sons A/S. ; link_to_subscribed_fulltext )
Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper )
Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English )
Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 0303-6979 )
Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => Journal of Clinical Periodontology; http://www.scopus.com/mlt/select.url?eid=2-s2.0-72549107943&amp;selection=ref&amp;src=s&amp;origin=recordpage; Journal Of Clinical Periodontology, 2010, v. 37 n. 1, p. 9-16; 6466146; 16; 169087; WOS:000272771700002; http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0303-6979&amp;volume=37&amp;spage=9&amp;epage=16&amp;date=2010&amp;atitle=Pro-inflammatory+biomarkers+during+experimental+gingivitis+in+patients+with+type+1+diabetes+mellitus:+a+proof-of-concept+study; eid_2-s2.0-72549107943; http://hdl.handle.net/10722/66053; 37 )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1111/j.1600-051X.2009.01500.x )
Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://doi.org/10.1111/j.1600-051X.2009.01500.x&lt;br /&gt;http://library.hku.hk:4550/resserv?sid=HKU:IR&amp;issn=0303-6979&amp;volume=37&amp;spage=9&amp;epage=16&amp;date=2010&amp;atitle=Pro-inflammatory+biomarkers+during+experimental+gingivitis+in+patients+with+type+1+diabetes+mellitus:+a+proof-of-concept+study&lt;br /&gt;http://hdl.handle.net/10722/66053 )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.1D1DED08 )
RecordInfo Array ( [BibEntity] => Array ( [Identifiers] => Array ( [0] => Array ( [Type] => doi [Value] => 10.1111/j.1600-051X.2009.01500.x ) ) [Languages] => Array ( [0] => Array ( [Text] => English ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => Periodontal Index [Type] => general ) [1] => Array ( [SubjectFull] => Nucleic Acid Hybridization [Type] => general ) [2] => Array ( [SubjectFull] => Matrix Metalloproteinase 9 - analysis [Type] => general ) [3] => Array ( [SubjectFull] => Matrix Metalloproteinase 8 - analysis [Type] => general ) [4] => Array ( [SubjectFull] => Interleukin-8 - analysis [Type] => general ) [5] => Array ( [SubjectFull] => Gingival Crevicular Fluid - chemistry [Type] => general ) [6] => Array ( [SubjectFull] => Gingivitis - metabolism [Type] => general ) [7] => Array ( [SubjectFull] => Case-Control Studies [Type] => general ) [8] => Array ( [SubjectFull] => Cohort Studies [Type] => general ) [9] => Array ( [SubjectFull] => Adolescent [Type] => general ) [10] => Array ( [SubjectFull] => Adult [Type] => general ) [11] => Array ( [SubjectFull] => Bacteria - classification [Type] => general ) [12] => Array ( [SubjectFull] => Biofilms [Type] => general ) [13] => Array ( [SubjectFull] => Biological Markers - analysis [Type] => general ) [14] => Array ( [SubjectFull] => Dental Plaque - microbiology [Type] => general ) [15] => Array ( [SubjectFull] => Humans [Type] => general ) [16] => Array ( [SubjectFull] => Interleukin-1beta - analysis [Type] => general ) [17] => Array ( [SubjectFull] => Inflammation Mediators - analysis [Type] => general ) [18] => Array ( [SubjectFull] => Dental Plaque Index [Type] => general ) [19] => Array ( [SubjectFull] => Diabetes Mellitus [Type] => general ) [20] => Array ( [SubjectFull] => Type 1 - complications - metabolism [Type] => general ) [21] => Array ( [SubjectFull] => Young Adult [Type] => general ) [22] => Array ( [SubjectFull] => Prospective Studies [Type] => general ) [23] => Array ( [SubjectFull] => Follow-Up Studies [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Pro-inflammatory biomarkers during experimental gingivitis in patients with type 1 diabetes mellitus: A proof-of-concept study [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Salvi, GE ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Giannobile, WV ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lee, A ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Rutger Persson, G ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Franco, LM ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Braun, TM ) ) ) [6] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lang, NP ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 01 [Type] => published [Y] => 2010 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-print [Value] => 03036979 ) [1] => Array ( [Type] => issn-locals [Value] => edsbas ) ) ) ) ) ) )
IllustrationInfo