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Prognostic impact of the glypican family of heparan sulfate proteoglycans on the survival of breast cancer patients

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العنوان: Prognostic impact of the glypican family of heparan sulfate proteoglycans on the survival of breast cancer patients
المؤلفون: Grillo, Paulina Karin, Gyorffy, Balazs, Götte, Martin
المصدر: http://lobid.org/resources/99370674181806441Test#!, 147(7):1937-1955.
سنة النشر: 2021
المجموعة: Publisso (ZB MED-Publikationsportal Lebenswissenschaften)
مصطلحات موضوعية: Gene Expression Regulation, Neoplastic [MeSH], Survival analysis, Protein Interaction Maps [MeSH], Aged, 80 and over [MeSH], Aged [MeSH], Glypicans, Glypicans/genetics [MeSH], Breast cancer, Prognosis, Tumor Cells, Cultured [MeSH], Gene expression, Breast Neoplasms/mortality [MeSH], Breast Neoplasms/pathology [MeSH], Female [MeSH], Follow-Up Studies [MeSH], Original Article – Cancer Research, Adult [MeSH], Humans [MeSH], Breast Neoplasms/genetics [MeSH], Breast Neoplasms/metabolism [MeSH], Middle Aged [MeSH], Proteoglycans, Glypicans/metabolism [MeSH], Survival Rate [MeSH], Biomarkers, Tumor/metabolism [MeSH], Tumor/genetics [MeSH]
الوصف: Purpose!#!Dysregulated expression of proteoglycans influences the outcome and progression of numerous cancers. Several studies have investigated the role of individual glypicans in cancer, however, the impact of the whole glypican family of heparan sulfate proteoglycans on prognosis of a large patient cohort of breast cancer patients has not yet been investigated. In the present study, our aim was to investigate the prognostic power of the glypicans in breast cancer patients.!##!Methods!#!We used a public database including both gene expression data and survival information for 3951 breast cancer patients to determine the prognostic value of glypicans on relapse-free survival using Cox regression analysis. Moreover, we performed quantitative Real-Time PCR to determine glypican gene expression levels in seven representative breast cancer cell lines.!##!Results!#!We found that high GPC3 levels were associated with a better prognosis in overall breast cancer patients. When stratified by hormone receptor status, we found that in worse prognosis subtypes low GPC1 levels correlate with a longer relapse-free survival, and in more favorable subtypes low GPC6 was associated with longer survival.!##!Conclusion!#!Our study concludes that glypicans could act as subtype-specific biomarkers for the prognosis of breast cancer patients and sparks hope for future research on glypicans possibly eventually providing targets for the treatment of the disease.
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: https://repository.publisso.de/resource/frl:6449886Test; https://doi.org/10.1007/s00432-021-03597-4Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164625Test/
DOI: 10.1007/s00432-021-03597-4
الإتاحة: https://doi.org/10.1007/s00432-021-03597-4Test
https://repository.publisso.de/resource/frl:6449886Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164625Test/
حقوق: https://creativecommons.org/licenses/by/4.0Test/
رقم الانضمام: edsbas.1CE0722E
قاعدة البيانات: BASE
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