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CRELD1 modulates homeostasis of the immune system in mice and humans.

التفاصيل البيبلوغرافية
العنوان: CRELD1 modulates homeostasis of the immune system in mice and humans.
المؤلفون: Bonaguro, Lorenzo, Köhne, Maren, Rahmouni, Souad, Georges, Michel, Falk, Christine S, Li, Yang, Mass, Elvira, Beyer, Marc-Daniel, Joosten, Leo A B, Netea, Mihai G, Ulas, Thomas, Schultze, Joachim, Schmidleithner, Lisa, Aschenbrenner, Anna C, Schulte-Schrepping, Jonas, Warnat-Herresthal, Stefanie, Horne, Arik, Kern, Paul, Günther, Patrick, Ter Horst, Rob, Jaeger, Martin
المصدر: Nature immunology 21(12), 1517 - 1527 (2020). doi:10.1038/s41590-020-00811-2
بيانات النشر: Springer Nature Limited
سنة النشر: 2020
مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Animals, Cell Adhesion Molecules: genetics, Cell Adhesion Molecules: metabolism, Cell Survival: genetics, Cell Survival: immunology, Extracellular Matrix Proteins: genetics, Extracellular Matrix Proteins: metabolism, Gene Expression, Gene Knockout Techniques, Homeostasis: immunology, Humans, Immune System: immunology, Immune System: metabolism, Immunomodulation, Immunosenescence, Lymphocyte Activation: genetics, Lymphocyte Activation: immunology, Lymphocyte Count, Mice, T-Lymphocytes: immunology, T-Lymphocytes: metabolism, Wnt Signaling Pathway, CRELD1 protein, human, mouse, Cell Adhesion Molecules, Extracellular Matrix Proteins
جغرافية الموضوع: DE
الوصف: CRELD1 is a pivotal factor for heart development, the function of which is unknown in adult life. We here provide evidence that CRELD1 is an important gatekeeper of immune system homeostasis. Exploiting expression variance in large human cohorts contrasting individuals with the lowest and highest CRELD1 expression levels revealed strong phenotypic, functional and transcriptional differences, including reduced CD4+ T cell numbers. These findings were validated in T cell-specific Creld1-deficient mice. Loss of Creld1 was associated with simultaneous overactivation and increased apoptosis, resulting in a net loss of T cells with age. Creld1 was transcriptionally and functionally linked to Wnt signaling. Collectively, gene expression variance in large human cohorts combined with murine genetic models, transcriptomics and functional testing defines CRELD1 as an important modulator of immune homeostasis.
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/pmid:33169013; info:eu-repo/semantics/altIdentifier/issn/1529-2916; info:eu-repo/semantics/altIdentifier/issn/1529-2908; https://pub.dzne.de/record/154270Test; https://pub.dzne.de/search?p=id:%22DZNE-2021-00124%22Test
الإتاحة: https://doi.org/10.1038/s41590-020-00811-2Test
https://pub.dzne.de/record/154270Test
https://pub.dzne.de/search?p=id:%22DZNE-2021-00124%22Test
حقوق: info:eu-repo/semantics/closedAccess
رقم الانضمام: edsbas.18753FC
قاعدة البيانات: BASE
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