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Comparison of telomere length and insulin-like growth factor-binding protein 7 promoter methylation between breast cancer tissues and adjacent normal tissues in Turkish women

التفاصيل البيبلوغرافية
العنوان: Comparison of telomere length and insulin-like growth factor-binding protein 7 promoter methylation between breast cancer tissues and adjacent normal tissues in Turkish women
المؤلفون: Kaya Z., Akkiprik M., Karabulut S., Peker I., Gullu Amuran G., Ozmen T., Gulluoglu B.M., Kaya H., Ozer A.
المساهمون: Bayburt University, 55876457500, 57195257114, 55771646300, 56448719400, 57192116611, 7801655696, 6603333281, 7102340078, 7005139386
بيانات النشر: John Wiley and Sons Inc.
المجموعة: Bayburt University Institutional Repository (DSpace@Bayburt)
مصطلحات موضوعية: breast cancer, insulin-like growth factor-binding protein 7, methylation, telomere, telomere length, insulin like growth factor binding protein 7, somatomedin binding protein, unclassified drug, insulin-like growth factor binding protein-related protein 1, adult, advanced cancer, Article, breast carcinoma, cancer grading, cancer growth, cancer staging, cancer tissue, controlled study, estrogen receptor positive breast cancer, family history, female, histology, human, human cell, human epidermal growth factor receptor 2 positive breast cancer, human tissue, major clinical study, menopause, mixed tumor, polymerase chain reaction
الوصف: Background: Both insulin-like growth factor-binding protein 7 (IGFBP7) and telomere length (TL) are associated with proliferation and senescence of human breast cancer. This study assessed the clinical significance of both TL and IGFBP7 methylation status in breast cancer tissues compared with adjacent normal tissues. We also investigated whether IGFBP7 methylation status could be affecting TL. Methods: Telomere length was measured by quantitative PCR to compare tumors with their adjacent normal tissues. The IGFBP7 promoter methylation status was evaluated by methylation-specific PCR and its expression levels were determined by western blotting. Results: Telomeres were shorter in tumor tissues compared to controls (P<.0001). The mean TL was higher in breast cancer with invasive ductal carcinoma (IDC; n=72; P=.014) compared with other histological type (n=29), and TL in IDC with HER2 negative (n=53; P=.017) was higher than TL in IDC with HER2 positive (n=19). However, telomeres were shortened in advanced stages and growing tumors. IGFBP7 methylation was observed in 90% of tumor tissues and 59% of controls (P=.0002). Its frequency was significantly higher in IDC compared with invasive mixed carcinoma (IMC; P=.002) and it was not correlated either with protein expression or the other clinicopathological parameters. Conclusion: These results suggest that IGFBP7 promoter methylation and shorter TL in tumor compared with adjacent tissues may be predictive biomarkers for breast cancer. Telomere maintenance may be indicative of IDC and IDC with HER2 (?) of breast cancer. Further studies with larger number of cases are necessary to verify this association. © 2016 Wiley Periodicals, Inc.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 0887-8013
العلاقة: Journal of Clinical Laboratory Analysis; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.1002/jcla.22083Test; https://hdl.handle.net/20.500.12403/478Test; 31
DOI: 10.1002/jcla.22083
الإتاحة: https://doi.org/20.500.12403/478Test
https://doi.org/10.1002/jcla.22083Test
https://hdl.handle.net/20.500.12403/478Test
حقوق: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.14E286BE
قاعدة البيانات: BASE
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