مراجعة
p21-activated kinase signaling in breast cancer
العنوان: | p21-activated kinase signaling in breast cancer |
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المؤلفون: | Gururaj, Anupama E, Rayala, Suresh K, Kumar, Rakesh |
بيانات النشر: | BioMed Central Ltd. |
سنة النشر: | 2004 |
المجموعة: | BioMed Central |
مصطلحات موضوعية: | breast cancer, hormone independence, mouse model, p21-activated kinase, Rho GTPase |
الوصف: | The p21-activated kinases signal through a number of cellular pathways fundamental to growth, differentiation and apoptosis. A wealth of information has accumulated at an impressive pace in the recent past, both with regard to previously identified targets for p21-activated kinases that regulate the actin cytoskeleton and cellular stress pathways and with regard to newly identified targets and their role in cancer. Emerging data also provide new clues towards a previously unappreciated link between these various cellular processes. The present review attempts to provide a quick tutorial to the reader about the evolving significance of p21-activated kinases and small GTPases in breast cancer, using information from mouse models, tissue culture studies, and human materials. |
نوع الوثيقة: | review |
اللغة: | English |
العلاقة: | http://breast-cancer-research.com/content/7/1/5Test |
الإتاحة: | http://breast-cancer-research.com/content/7/1/5Test |
حقوق: | Copyright 2004 BioMed Central Ltd |
رقم الانضمام: | edsbas.11738E41 |
قاعدة البيانات: | BASE |
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