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Kynurenine/Tryptophan Ratio as a Potential Blood-Based Biomarker in Non-Small Cell Lung Cancer

التفاصيل البيبلوغرافية
العنوان: Kynurenine/Tryptophan Ratio as a Potential Blood-Based Biomarker in Non-Small Cell Lung Cancer
المؤلفون: Mandarano, Martina, Orecchini, Elena, Bellezza, Guido, Vannucci, Jacopo, Ludovini, Vienna, Baglivo, Sara, Tofanetti, Francesca Romana, Chiari, Rita, Loreti, Elisabetta, Puma, Francesco, Sidoni, Angelo, Belladonna, Maria Laura
المساهمون: Mandarano, Martina, Orecchini, Elena, Bellezza, Guido, Vannucci, Jacopo, Ludovini, Vienna, Baglivo, Sara, Tofanetti, Francesca Romana, Chiari, Rita, Loreti, Elisabetta, Puma, Francesco, Sidoni, Angelo, Belladonna, Maria Laura
بيانات النشر: MDPI
ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
سنة النشر: 2021
المجموعة: Sapienza Università di Roma: CINECA IRIS
مصطلحات موضوعية: immunohistochemical biomarker, indoleamine-2,3-dioxygenase 1 (IDO1), kynurenine/tryptophan (Kyn/Trp) ratio, non-small cell lung cancer (NSCLC), serum biomarker, adenocarcinoma of lung, adult, aged, 80 and over, B7-H1 antigen, biomarkers, tumor, carcinoma, non-small-cell lung, squamous cell, female, follow-up studie, human, indoleamine-pyrrole 2,3,-dioxygenase, kynurenine, lung neoplasm, lymphocytes, tumor-infiltrating, male, middle aged, neoplasm recurrence, local, prognosi, survival rate, tryptophan
الوصف: The enzyme indoleamine 2,3-dioxygenase 1 (IDO1) degrade tryptophan (Trp) into kynurenine (Kyn) at the initial step of an enzymatic pathway affecting T cell proliferation. IDO1 is highly expressed in various cancer types and associated with poor prognosis. Nevertheless, the serum Kyn/Trp concentration ratio has been suggested as a marker of cancer-associated immune suppression. We measured Kyn and Trp in blood samples of a wide cohort of non-small-cell lung cancer (NSCLC) patients, before they underwent surgery, and analyzed possible correlations of the Kyn/Trp ratio with either IDO1 expression or clinical-pathological parameters. Low Kyn/Trp significantly correlated with low IDO1 expression and never-smoker patients; while high Kyn/Trp was significantly associated with older (>= 68 years) patients, advanced tumor stage, and squamous cell carcinoma (Sqcc), rather than the adenocarcinoma (Adc) histotype. Moreover, high Kyn/Trp was associated, among the Adc group, with higher tumor stages (II and III), and, among the Sqcc group, with a high density of tumor-infiltrating lymphocytes. A trend correlating the high Kyn/Trp ratio with the probability of recurrences from NSCLC was also found. In conclusion, high serum Kyn/Trp ratio, associated with clinical and histopathological parameters, may serve as a serum biomarker to optimize risk stratification and therapy of NSCLC patients.
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33922388; info:eu-repo/semantics/altIdentifier/wos/WOS:000650354800001; volume:22; issue:9; numberofpages:14; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; https://hdl.handle.net/11573/1660546Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85104497944
DOI: 10.3390/ijms22094403
الإتاحة: https://doi.org/10.3390/ijms22094403Test
https://hdl.handle.net/11573/1660546Test
حقوق: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.10517747
قاعدة البيانات: BASE
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