Circulating NK cells and their subsets in Behçet's disease
| العنوان: | Circulating NK cells and their subsets in Behçet's disease |
|---|---|
| المؤلفون: | Hasan, M. S., Ryan, P. L., Bergmeier, L. A., Fortune, F. |
| المصدر: | Clinical and Experimental Immunology |
| بيانات النشر: | John Wiley and Sons Inc., 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, Adolescent, NK cells, GPI-Linked Proteins, immunotherapies and innate immunity, Granzymes, Interferon-gamma, Young Adult, Lysosomal-Associated Membrane Protein 1, Azathioprine, immunopathology, Humans, Aged, Inflammation, Behçet's disease, Perforin, Behcet Syndrome, Translational, Receptors, IgG, Original Articles, Middle Aged, CD56 Antigen, Lymphocyte Subsets, Killer Cells, Natural, Blood Circulation, Original Article, Female |
| الوصف: | Summary Behçet's disease (BD) is an autoinflammatory, chronic relapsing/remitting disease of unknown aetiology with both innate and acquired immune cells implicated in disease pathogenesis. Peripheral blood natural killer (NK) cells and their CD56Dim/CD56Bright subsets were surface phenotyped using CD27 and CD16 surface markers in 60 BD patients compared to 60 healthy controls (HCs). Functional potential was assessed by production of interferon (IFN)‐γ, granzyme B, perforin and the expression of degranulation marker CD107a. The effects of disease activity (BDActive versus BDQuiet) and BD medication on NK cells were also investigated. Peripheral blood NK cells (P |
| اللغة: | English |
| تدمد: | 1365-2249 0009-9104 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::61c7a8a29730f806e556f7d64dc27c8fTest http://europepmc.org/articles/PMC5383445Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........61c7a8a29730f806e556f7d64dc27c8f |
| قاعدة البيانات: | OpenAIRE |
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