Current whole-body MRI applications in the neurofibromatoses: NF1, NF2, and schwannomatosis
| العنوان: | Current whole-body MRI applications in the neurofibromatoses: NF1, NF2, and schwannomatosis |
|---|---|
| المؤلفون: | Ahlawat, Shivani, Fayad, Laura M, Khan, Muhammad Shayan, Bredella, Miriam A, Harris, Gordon J, Evans, D Gareth, Farschtschi, Said, Jacobs, Michael A, Chhabra, Avneesh, Salamon, Johannes M, Wenzel, Ralph, Mautner, Victor F, Dombi, Eva, Cai, Wenli, Plotkin, Scott R, Blakeley, Jaishri O, Whole Body MRI Committee for the REiNS International Collaboration, REiNS International Collaboration Members 2016 |
| المصدر: | Neurology, vol 87, iss 7 Suppl 1 |
| بيانات النشر: | eScholarship, University of California, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Neurofibromatosis 2, Clinical Trials as Topic, screening and diagnosis, Neurofibromatosis 1, Skin Neoplasms, Neurology & Neurosurgery, Neurofibromatoses, Clinical Sciences, Neurosciences, REiNS International Collaboration Members 2016, Magnetic Resonance Imaging, Neurofibromatosis, Detection, Rare Diseases, Clinical Research, Whole Body MRI Committee for the REiNS International Collaboration, Humans, Multicenter Studies as Topic, Biomedical Imaging, Whole Body Imaging, Cognitive Sciences, Neurilemmoma, Cancer, 4.2 Evaluation of markers and technologies |
| الوصف: | ObjectivesThe Response Evaluation in Neurofibromatosis and Schwannomatosis (REiNS) International Collaboration Whole-Body MRI (WB-MRI) Working Group reviewed the existing literature on WB-MRI, an emerging technology for assessing disease in patients with neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN), to recommend optimal image acquisition and analysis methods to enable WB-MRI as an endpoint in NF clinical trials.MethodsA systematic process was used to review all published data about WB-MRI in NF syndromes to assess diagnostic accuracy, feasibility and reproducibility, and data about specific techniques for assessment of tumor burden, characterization of neoplasms, and response to therapy.ResultsWB-MRI at 1.5T or 3.0T is feasible for image acquisition. Short tau inversion recovery (STIR) sequence is used in all investigations to date, suggesting consensus about the utility of this sequence for detection of WB tumor burden in people with NF. There are insufficient data to support a consensus statement about the optimal imaging planes (axial vs coronal) or 2D vs 3D approaches. Functional imaging, although used in some NF studies, has not been systematically applied or evaluated. There are no comparative studies between regional vs WB-MRI or evaluations of WB-MRI reproducibility.ConclusionsWB-MRI is feasible for identifying tumors using both 1.5T and 3.0T systems. The STIR sequence is a core sequence. Additional investigation is needed to define the optimal approach for volumetric analysis, the reproducibility of WB-MRI in NF, and the diagnostic performance of WB-MRI vs regional MRI. |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=od_______325::73046b4b95083546c27fd56c4a878fedTest https://escholarship.org/uc/item/9fk3x4pzTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.od.......325..73046b4b95083546c27fd56c4a878fed |
| قاعدة البيانات: | OpenAIRE |
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International Collaboration Whole-Body MRI (WB-MRI) Working Group reviewed the existing literature on WB-MRI, an emerging technology for assessing disease in patients with neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN), to recommend optimal image acquisition and analysis methods to enable WB-MRI as an endpoint in NF clinical trials.MethodsA systematic process was used to review all published data about WB-MRI in NF syndromes to assess diagnostic accuracy, feasibility and reproducibility, and data about specific techniques for assessment of tumor burden, characterization of neoplasms, and response to therapy.ResultsWB-MRI at 1.5T or 3.0T is feasible for image acquisition. 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