أعرض في EDS

Alterations of Mast Cells in the Esophageal Mucosa of the Patients With Non-Erosive Reflux Disease

التفاصيل البيبلوغرافية
العنوان: Alterations of Mast Cells in the Esophageal Mucosa of the Patients With Non-Erosive Reflux Disease
المؤلفون: Xi-ping Ding, Yue Yu, Li Xie, Ke Chen, Qiao-min Wang, Wen Hu
المصدر: Gastroenterology Research
سنة النشر: 2011
مصطلحات موضوعية: medicine.medical_specialty, Pathology, Gastrointestinal tract, business.industry, Nerd, Degranulation, Reflux, Mast cell, Gastroenterology, behavioral disciplines and activities, humanities, Pathogenesis, medicine.anatomical_structure, Esophagus, Internal medicine, Medicine, Immunohistochemistry, Original Article, Non-erosive reflux disease, business
الوصف: Background : Mast cells (MCs) are widely distributed in the gastrointestinal tract, which could be involved in visceral hypersensitivity and gut dysmotility. Whether esophageal MCs play a role in non-erosive reflux disease (NERD) has yet to be determined. The aim of this study was to characterize esophageal MCs distribution, degranulation, and ultrastructure. Methods : The esophageal mucosa at 5 cm above the end of esophagus was obtained from 26 NERD and 14 healthy volunteers (control) by gastroscopy. Immunohistochemistry was performed and average MC counts per high-power field (HPF) and the percentage of degranulated MCs were obtained. The ultrastructure of MCs was observed by transmission electron microscope (TEM). Results : More MCs were observed in NERD (7.23 ± 2.41 cells/HPF) as compared with controls (3.79 ± 1.67 cells/HPF) (P < 0.01) and the percentage of degranulated MCs in NERD was also significantly higher than controls (26.85 ± 8.79% vs 11.5 ± 4.18%, P < 0.01). Under TEM, more Golgi apparatus, mitochondria and endoplasmic reticulum were found in MCs in patients with NERD. Special secreting particles were also found in cytoplasm, more vacuoles were left after MCs degranulation in patients with NERD. Conclusions : Our results indicate that increased numbers of MCs and MCs activation may be involved in the pathogenesis of NERD. doi:10.4021/gr284w
تدمد: 1918-2805
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47e1be896eb8ab6300f0d75df5d2cc7Test
https://pubmed.ncbi.nlm.nih.gov/27942317Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....f47e1be896eb8ab6300f0d75df5d2cc7
قاعدة البيانات: OpenAIRE
ResultId 1
Header edsair
OpenAIRE
edsair.doi.dedup.....f47e1be896eb8ab6300f0d75df5d2cc7
770
3

unknown
769.66943359375
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....f47e1be896eb8ab6300f0d75df5d2cc7&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Alterations of Mast Cells in the Esophageal Mucosa of the Patients With Non-Erosive Reflux Disease )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xi-ping+Ding%22&quot;&gt;Xi-ping Ding&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yue+Yu%22&quot;&gt;Yue Yu&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li+Xie%22&quot;&gt;Li Xie&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ke+Chen%22&quot;&gt;Ke Chen&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Qiao-min+Wang%22&quot;&gt;Qiao-min Wang&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wen+Hu%22&quot;&gt;Wen Hu&lt;/searchLink&gt; )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Gastroenterology Research )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2011 )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22medicine%2Emedical%5Fspecialty%22&quot;&gt;medicine.medical_specialty&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Pathology%22&quot;&gt;Pathology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Gastrointestinal+tract%22&quot;&gt;Gastrointestinal tract&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22business%2Eindustry%22&quot;&gt;business.industry&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Nerd%22&quot;&gt;Nerd&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Degranulation%22&quot;&gt;Degranulation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Reflux%22&quot;&gt;Reflux&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mast+cell%22&quot;&gt;Mast cell&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Gastroenterology%22&quot;&gt;Gastroenterology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22behavioral+disciplines+and+activities%22&quot;&gt;behavioral disciplines and activities&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22humanities%22&quot;&gt;humanities&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Pathogenesis%22&quot;&gt;Pathogenesis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22medicine%2Eanatomical%5Fstructure%22&quot;&gt;medicine.anatomical_structure&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Esophagus%22&quot;&gt;Esophagus&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Internal+medicine%22&quot;&gt;Internal medicine&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Medicine%22&quot;&gt;Medicine&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Immunohistochemistry%22&quot;&gt;Immunohistochemistry&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Original+Article%22&quot;&gt;Original Article&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Non-erosive+reflux+disease%22&quot;&gt;Non-erosive reflux disease&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22business%22&quot;&gt;business&lt;/searchLink&gt; )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Background : Mast cells (MCs) are widely distributed in the gastrointestinal tract, which could be involved in visceral hypersensitivity and gut dysmotility. Whether esophageal MCs play a role in non-erosive reflux disease (NERD) has yet to be determined. The aim of this study was to characterize esophageal MCs distribution, degranulation, and ultrastructure. Methods : The esophageal mucosa at 5 cm above the end of esophagus was obtained from 26 NERD and 14 healthy volunteers (control) by gastroscopy. Immunohistochemistry was performed and average MC counts per high-power field (HPF) and the percentage of degranulated MCs were obtained. The ultrastructure of MCs was observed by transmission electron microscope (TEM). Results : More MCs were observed in NERD (7.23 &#177; 2.41 cells/HPF) as compared with controls (3.79 &#177; 1.67 cells/HPF) (P &lt; 0.01) and the percentage of degranulated MCs in NERD was also significantly higher than controls (26.85 &#177; 8.79% vs 11.5 &#177; 4.18%, P &lt; 0.01). Under TEM, more Golgi apparatus, mitochondria and endoplasmic reticulum were found in MCs in patients with NERD. Special secreting particles were also found in cytoplasm, more vacuoles were left after MCs degranulation in patients with NERD. Conclusions : Our results indicate that increased numbers of MCs and MCs activation may be involved in the pathogenesis of NERD. doi:10.4021/gr284w )
Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1918-2805 )
Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => &lt;link linkTarget=&quot;URL&quot; linkTerm=&quot;https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47e1be896eb8ab6300f0d75df5d2cc7&quot; linkWindow=&quot;_blank&quot;&gt;https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47e1be896eb8ab6300f0d75df5d2cc7&lt;/link&gt;&lt;br /&gt;&lt;link linkTarget=&quot;URL&quot; linkTerm=&quot;https://pubmed.ncbi.nlm.nih.gov/27942317&quot; linkWindow=&quot;_blank&quot;&gt;https://pubmed.ncbi.nlm.nih.gov/27942317&lt;/link&gt; )
Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....f47e1be896eb8ab6300f0d75df5d2cc7 )
RecordInfo Array ( [BibEntity] => Array ( [Languages] => Array ( [0] => Array ( [Text] => Undetermined ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => medicine.medical_specialty [Type] => general ) [1] => Array ( [SubjectFull] => Pathology [Type] => general ) [2] => Array ( [SubjectFull] => Gastrointestinal tract [Type] => general ) [3] => Array ( [SubjectFull] => business.industry [Type] => general ) [4] => Array ( [SubjectFull] => Nerd [Type] => general ) [5] => Array ( [SubjectFull] => Degranulation [Type] => general ) [6] => Array ( [SubjectFull] => Reflux [Type] => general ) [7] => Array ( [SubjectFull] => Mast cell [Type] => general ) [8] => Array ( [SubjectFull] => Gastroenterology [Type] => general ) [9] => Array ( [SubjectFull] => behavioral disciplines and activities [Type] => general ) [10] => Array ( [SubjectFull] => humanities [Type] => general ) [11] => Array ( [SubjectFull] => Pathogenesis [Type] => general ) [12] => Array ( [SubjectFull] => medicine.anatomical_structure [Type] => general ) [13] => Array ( [SubjectFull] => Esophagus [Type] => general ) [14] => Array ( [SubjectFull] => Internal medicine [Type] => general ) [15] => Array ( [SubjectFull] => Medicine [Type] => general ) [16] => Array ( [SubjectFull] => Immunohistochemistry [Type] => general ) [17] => Array ( [SubjectFull] => Original Article [Type] => general ) [18] => Array ( [SubjectFull] => Non-erosive reflux disease [Type] => general ) [19] => Array ( [SubjectFull] => business [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Alterations of Mast Cells in the Esophageal Mucosa of the Patients With Non-Erosive Reflux Disease [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Xi-ping Ding ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Yue Yu ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Li Xie ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Ke Chen ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Qiao-min Wang ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Wen Hu ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 15 [M] => 02 [Type] => published [Y] => 2011 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-print [Value] => 19182805 ) [1] => Array ( [Type] => issn-locals [Value] => edsair ) [2] => Array ( [Type] => issn-locals [Value] => edsairFT ) ) [Numbering] => Array ( [0] => Array ( [Type] => volume [Value] => 4 ) [1] => Array ( [Type] => issue [Value] => 2 ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Gastroenterology research [Type] => main ) ) ) ) ) ) )
IllustrationInfo