The Different Roles of hRAD50 in Microsatellite Stable and Unstable Colorectal Cancers
| العنوان: | The Different Roles of hRAD50 in Microsatellite Stable and Unstable Colorectal Cancers |
|---|---|
| المؤلفون: | Jingfang Gao, Hong Zhang, Xiao-Feng Sun, Gunnar Arbman |
| المصدر: | Disease markers Disease Markers, Vol 24, Iss 2, Pp 127-134 (2008) |
| بيانات النشر: | IOS Press, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | hRAD50, Adult, Male, congenital, hereditary, and neonatal diseases and abnormalities, DNA repair, Clinical Biochemistry, Biology, medicine.disease_cause, Frameshift mutation, microsatellite stability, Intestinal mucosa, Genetics, medicine, Coding region, Humans, DNA Breaks, Double-Stranded, Intestinal Mucosa, Molecular Biology, neoplasms, Aged, lcsh:R5-920, Mutation, Biochemistry (medical), Microsatellite instability, General Medicine, Middle Aged, medicine.disease, Molecular biology, Colorectal cancer, digestive system diseases, Acid Anhydride Hydrolases, DNA-Binding Proteins, DNA Repair Enzymes, Rad50, immunohistochemistry, Immunohistochemistry, Female, Microsatellite Instability, Other, lcsh:Medicine (General), Colorectal Neoplasms |
| الوصف: | RAD50 protein is essential for DNA double-strand break repair and maintaining genomic integrity. In this study, we investigated the clinicopathological significance of hRAD50 expression and mutation in microsatellite stable (MSS) and unstable (MSI) colorectal cancers (CRCs). hRAD50 expression was examined in primary CRC (n=268), the corresponding distant (n=69) and adjacent normal mucosa (n=138), and lymph node metastasis (n=44) by immunohistochemistry. hRAD50 mutation was analyzed in 87 primary CRCs by PCR-SSCP-DNA sequencing. hRAD50 expression was increased in MSS primary CRCs, but not MSI ones, compared with distant/adjacent normal mucosa (pp=0.05) to early tumor stage, better differentiation, high inflammatory infiltration, p53 overexpression. Frameshift mutations of (A)9at coding region ofhRAD50were only found in MSI CRCs. Our results suggest that hRAD50 may play different roles in the development of MSS and MSI CRCs: increased hRAD50 expression in MSS CRCs may be a cellular response against tumor from further progression, whilehRAD50mutation may be involved in the development of MSI CRCs. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1875-8630 0278-0240 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd8da09226e954c923eb1d47b5cd4a4Test http://europepmc.org/articles/PMC3850595Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....edd8da09226e954c923eb1d47b5cd4a4 |
| قاعدة البيانات: | OpenAIRE |
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