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N-acetyltransferase-2 genotypes among Jordanian patients with diabetes mellitus

التفاصيل البيبلوغرافية
العنوان: N-acetyltransferase-2 genotypes among Jordanian patients with diabetes mellitus
المؤلفون: Yazun Jarrar, Yacoub M. Irshaid, Mousa Abujbara, Kamel Ajlouni, Mohammed El-Khateeb
المصدر: Int. Journal of Clinical Pharmacology and Therapeutics. 51:593-599
بيانات النشر: Dustri-Verlgag Dr. Karl Feistle, 2013.
سنة النشر: 2013
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, Genotype, Arylamine N-Acetyltransferase, Type 2 diabetes, Young Adult, Gene Frequency, Polymorphism (computer science), Internal medicine, Diabetes mellitus, Odds Ratio, medicine, Humans, Pharmacology (medical), N acetyltransferase 2, Child, Genotyping, Aged, Pharmacology, Type 1 diabetes, Chi-Square Distribution, Jordan, business.industry, Acetylation, Sequence Analysis, DNA, Middle Aged, medicine.disease, Arabs, Diabetes Mellitus, Type 1, Phenotype, Endocrinology, Diabetes Mellitus, Type 2, Case-Control Studies, Female, business
الوصف: Background: There are incon- sistent reports concerning N-acetyltransfer- ase 2 (NAT2) genotypes in diabetes mellitus (DM). Objective: The objective of the study was to explore any association between NAT2 genotypes and Type 1 and Type 2 DM in Jordanians. Methods: 106 Type 1 and 110 Type 2 DM patients attending the "National Center for Diabetes, Endocrinology and Ge- netics", Amman, Jordan, were included in the study. DNA was extracted from venous blood using a commercial DNA extraction kit. NAT2 genotyping was performed using polymerase chain reaction-restriction frag- ment length polymorphism (PCR-RFLP). Results: The frequency of the genotype that encodes rapid acetylation (the wild-type genotype NAT2*4/4) was similar in the two types of diabetes mellitus. Those which en- code intermediate acetylation (NAT2*4/5, NAT2*4/6, and NAT2*4/7) were higher in Type 2 diabetes (0.482) compared to Type 1 diabetes (0.339), while the frequency of genotypes which encode slow acetyla- tion (NAT2*5/5, NAT2*5/6, NAT2*5/7, NAT2*6/6, NAT2*6/7, and NAT2*7/7) were higher in Type 1 diabetes (0.547) compared to Type 2 diabetes (0.418). Conclusion: There is excess of genotypes encoding intermedi- ate acetylation in Type 2 DM and an excess of slow acetylator genotypes in Type 1 DM. Furthermore, NAT2*4/6 genotype (which encodes intermediate acetylation) was more prevalent in Type 2 DM. Type 1 DM behaved similar to non-diabetic controls in regard to acetylation status.
تدمد: 0946-1965
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f959d9217aa3e981fb06b7ac57519fTest
https://doi.org/10.5414/cp201883Test
رقم الانضمام: edsair.doi.dedup.....e8f959d9217aa3e981fb06b7ac57519f
قاعدة البيانات: OpenAIRE
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