Association of gender, ABCA1 gene polymorphisms and lipid profile in Greek young nurses
| العنوان: | Association of gender, ABCA1 gene polymorphisms and lipid profile in Greek young nurses |
|---|---|
| المؤلفون: | Georgios Vasilopoulos, Dimitrios Degiannis, Agathi Karakosta, Christina Marvaki, Apostolia Marvaki, Genovefa Kolovou, Vana Kolovou, Sophie Mavrogeni, Antonia Kalogiani |
| المصدر: | Lipids in Health and Disease Lipids in Health and Disease, Vol 11, Iss 1, p 62 (2012) |
| بيانات النشر: | BioMed Central, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Blood lipids, Nurses, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Young Adult, Endocrinology, Gene Frequency, Internal medicine, Genotype, medicine, ABCA1 Gene, Humans, lcsh:RC620-627, Allele frequency, Genetic Association Studies, Genetics, Biochemistry, medical, Electrophoresis, Agar Gel, Sex Characteristics, biology, medicine.diagnostic_test, Greece, Research, Biochemistry (medical), Lipids, lcsh:Nutritional diseases. Deficiency diseases, biology.protein, Population study, Apolipoprotein A1, lipids (amino acids, peptides, and proteins), ATP-Binding Cassette Transporters, Female, Lipid profile, ATP Binding Cassette Transporter 1 |
| الوصف: | Objective One of the important proteins involved in lipid metabolism is the ATP-binding cassette transporter A1 (ABCA1) encoding by ABCA1 gene. In this study we evaluated the single nucleotide polymorphisms (SNPs) of ABCA1 gene. We analyzed SNPs in chromosome 9 such as rs2230806 (R219K) in the position 107620867, rs2230808 (R1587K) in the position 106602625 and rs4149313 (I883M) in the position 106626574 according to gender and lipid profile of Greek nurses. Methods The study population consisted of 447 (87 men) unrelated nurses who were genotyped for ABCA1 gene polymorphisms. Additionally, lipid profile [total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol (LDL-C) and apolipoprotein A1] was evaluated. Results The distribution of all three studied ABCA1 gene polymorphisms did not differ according to gender. However, only R219K genotype distribution bared borderline statistical significance (p = 0.08) between the two studied groups. Moreover, allele frequencies of R219K, R1587K and I88M polymorphisms did not differ according to gender. In general, blood lipid levels did not seem to vary according to ABCA1 gene polymorphisms, when testing all subjects or when testing only men or only women. However, a significant difference of LDL-C distribution was detected in all subjects according to R1587K genotype, indicating lower LDL-C levels with KK polymorphism (p = 0.0025). The above difference was solely detected on female population (p = 0.0053). Conclusions The ABCA1 gene polymorphisms frequency, distribution and lipid profile did not differ according to gender. However, in the female population the KK genotype of R1587K gene indicated lower LDL-C levels. Further studies, involving a higher number of individuals, are required to clarify genes and gender contribution. |
| اللغة: | English |
| تدمد: | 1476-511X 1076-2086 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52c5890ed239a8a816b20569f70cf25Test http://europepmc.org/articles/PMC3391977Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e52c5890ed239a8a816b20569f70cf25 |
| قاعدة البيانات: | OpenAIRE |
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In this study we evaluated the single nucleotide polymorphisms (SNPs) of ABCA1 gene. We analyzed SNPs in chromosome 9 such as rs2230806 (R219K) in the position 107620867, rs2230808 (R1587K) in the position 106602625 and rs4149313 (I883M) in the position 106626574 according to gender and lipid profile of Greek nurses. Methods The study population consisted of 447 (87 men) unrelated nurses who were genotyped for ABCA1 gene polymorphisms. Additionally, lipid profile [total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol (LDL-C) and apolipoprotein A1] was evaluated. Results The distribution of all three studied ABCA1 gene polymorphisms did not differ according to gender. However, only R219K genotype distribution bared borderline statistical significance (p = 0.08) between the two studied groups. Moreover, allele frequencies of R219K, R1587K and I88M polymorphisms did not differ according to gender. In general, blood lipid levels did not seem to vary according to ABCA1 gene polymorphisms, when testing all subjects or when testing only men or only women. However, a significant difference of LDL-C distribution was detected in all subjects according to R1587K genotype, indicating lower LDL-C levels with KK polymorphism (p = 0.0025). The above difference was solely detected on female population (p = 0.0053). Conclusions The ABCA1 gene polymorphisms frequency, distribution and lipid profile did not differ according to gender. However, in the female population the KK genotype of R1587K gene indicated lower LDL-C levels. 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