The combination of aldehyde dehydrogenase 1 (ALDH1) and CD44 is associated with poor outcomes in endometrial cancer
| العنوان: | The combination of aldehyde dehydrogenase 1 (ALDH1) and CD44 is associated with poor outcomes in endometrial cancer |
|---|---|
| المؤلفون: | Hsin-Hui Huang, Tai Kuang Chao, Mu-Hsien Yu, Yu-Ching Chou, Yu Chi Wang |
| المصدر: | PLoS ONE, Vol 13, Iss 10, p e0206685 (2018) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, medicine.medical_treatment, lcsh:Medicine, Immunostaining, Kaplan-Meier Estimate, Endometrium, Pathology and Laboratory Medicine, Targeted therapy, 0302 clinical medicine, Medicine and Health Sciences, lcsh:Science, Staining, Aged, 80 and over, Multidisciplinary, Tissue microarray, Middle Aged, Prognosis, Isoenzymes, medicine.anatomical_structure, Hyaluronan Receptors, 030220 oncology & carcinogenesis, Immunohistochemistry, Female, Anatomy, Endometrial Carcinoma, Research Article, Adult, medicine.medical_specialty, Histology, Research and Analysis Methods, Carcinomas, Aldehyde Dehydrogenase 1 Family, 03 medical and health sciences, Signs and Symptoms, Uterine Cancer, Uterine cancer, Diagnostic Medicine, Internal medicine, medicine, Biomarkers, Tumor, Humans, Clinical significance, Aged, business.industry, Endometrial cancer, Uterus, lcsh:R, Reproductive System, Cancer, Cancers and Neoplasms, Biology and Life Sciences, Retinal Dehydrogenase, medicine.disease, Survival Analysis, Endometrial Neoplasms, 030104 developmental biology, Specimen Preparation and Treatment, Tissue Array Analysis, Lesions, lcsh:Q, business, Gynecological Tumors |
| الوصف: | Aldehyde dehydrogenase 1 (ALDH1) and CD44 have been established as biomarkers for predicting the survival of many types of cancer patients. This study evaluated the expression and clinical significance of these putative cancer-cell markers in a series of tumor samples from endometrial cancer (EC) patients using tissue microarray. We examined 245 endometrial samples, including 132 (53.87%) pre-malignancy lesions and 113 (46.12%) malignant endometrial lesions from biopsies or hysterectomies. We examined the expression of CD44 and ALDH1 in these samples using immunohistochemistry staining. Correlations in the relative expression of these markers with clinicopathological parameters were also assessed. A high level of expression of ALDH1 was found in 44.25% (50/113) of the endometrial cancer samples, which was significantly correlated with a poor overall survival rate (p = 0.035). High-level CD44 expression was found in 35.4% (40/113) of the cases and was also correlated with a poor overall survival rate (p = 0.035). A simultaneous high expression of both markers was correlated with an extremely poor overall survival (p = 0.013). Our results show that tumors with higher expressions of both ALDH1 and CD44 were related to a poorer overall survival rate among EC patients. The combination of ALDH1 and CD44 could be a promising marker for developing additional targeted therapy for severe endometrial cancers. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f47dfa83c78125be81124b1d7639f7Test http://europepmc.org/articles/PMC6205661?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e3f47dfa83c78125be81124b1d7639f7 |
| قاعدة البيانات: | OpenAIRE |
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