A ventral root avulsion injury model for neurogenic underactive bladder studies
| العنوان: | A ventral root avulsion injury model for neurogenic underactive bladder studies |
|---|---|
| المؤلفون: | Huiyi H. Chang, Leif A. Havton |
| المصدر: | Experimental neurology, vol 285, iss Pt B |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Urologic Diseases, 0301 basic medicine, Serotonin, Physical Injury - Accidents and Adverse Effects, media_common.quotation_subject, Clinical Sciences, And conus medullaris, Cauda equine, Spinal cord injury, Neurodegenerative, Underactive bladder, Urination, Article, 03 medical and health sciences, 0302 clinical medicine, Developmental Neuroscience, medicine, Psychology, Animals, Humans, Traumatic Head and Spine Injury, media_common, Neurology & Neurosurgery, Animal, Electromyography, business.industry, Urinary retention, Neurosciences, Urinary Bladder Diseases, Cauda equina, medicine.disease, Spinal cord, External urethral sphincter, Conus medullaris, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Neurology, Anesthesia, Disease Models, Spinal Diseases, medicine.symptom, Urinary bladder disease, business, Spinal Nerve Roots, 030217 neurology & neurosurgery |
| الوصف: | Detrusor underactivity (DU) is defined as a contraction of reduced strength and/or duration during bladder emptying and results in incomplete and prolonged bladder emptying. The clinical diagnosis of DU is challenging when present alone or in association with other bladder conditions such as detrusor overactivity, urinary retention, detrusor hyperactivity with impaired contractility, aging, and neurological injuries. Several etiologies may be responsible for DU or the development of an underactive bladder (UAB), but the pathobiology of DU or UAB is not well understood. Therefore, new clinically relevant and interpretable models for studies of UAB are much needed in order to make progress towards new treatments and preventative strategies. Here, we review a neuropathic cause of DU in the form of traumatic injuries to the cauda equina (CE) and conus medullaris (CM) portions of the spinal cord. Lumbosacral ventral root avulsion (VRA) injury models in rats mimic the clinical phenotype of CM/CE injuries. Bilateral VRA injuries result in bladder areflexia, whereas a unilateral lesion results in partial impairment of lower urinary tract and visceromotor reflexes. Surgical re-implantation of avulsed ventral roots into the spinal cord and pharmacological strategies can augment micturition reflexes. The translational research need for the development of a large animal model for UAB studies is also presented, and early studies of lumbosacral VRA injuries in rhesus macaques are discussed. |
| وصف الملف: | application/pdf |
| تدمد: | 1090-2430 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e8c32e4e4d2cc8c34fd0009371e98eTest https://pubmed.ncbi.nlm.nih.gov/27222131Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e1e8c32e4e4d2cc8c34fd0009371e98e |
| قاعدة البيانات: | OpenAIRE |
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