Effect and impact of mechanical ventilation in myotonic dystrophy type 1: a prospective cohort study
| العنوان: | Effect and impact of mechanical ventilation in myotonic dystrophy type 1: a prospective cohort study |
|---|---|
| المؤلفون: | Hélène Prigent, Frédéric Lofaso, Pascal Laforêt, Ghilas Boussaïd, Jean-Claude Raphaël, Djillali Annane, David Orlikowski |
| المصدر: | Thorax. 73:1075-1078 |
| بيانات النشر: | BMJ, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, medicine.medical_treatment, Myotonic dystrophy, Home ventilation, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Myotonic Dystrophy, Medicine, Non-invasive ventilation, In patient, Prospective Studies, Prospective cohort study, Mechanical ventilation, Proportional hazards model, business.industry, Prognosis, medicine.disease, Respiration, Artificial, Respiratory Function Tests, Survival Rate, 030228 respiratory system, Breathing, Patient Compliance, Female, France, Respiratory Insufficiency, business, 030217 neurology & neurosurgery, Follow-Up Studies |
| الوصف: | Few studies have assessed the impact of home ventilation in patients with myotonic dystrophy type 1 (DM1) and no specific recommendations are available. We assessed the survival associated with category of home ventilation adherence of patients with DM1 followed up at a home ventilation unit using a Cox proportional hazards model. 218 patients were included; those who refused or delayed their acceptance of non-invasive ventilation were at higher risk for severe events (invasive ventilation or death) (P=0.03). Risk of death was associated with orthopnoea (HR 2.37; 95% CI 1.17 to 4.80; P75%: HR 3.26; 95% CI 1.32 to 8.04; P |
| تدمد: | 1468-3296 0040-6376 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3dda253991ba12111bff08ddec0e8fTest https://doi.org/10.1136/thoraxjnl-2017-210610Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....db3dda253991ba12111bff08ddec0e8f |
| قاعدة البيانات: | OpenAIRE |
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