Tart cherry (Prunus cerasus L.) dietary supplement modulates visceral adipose tissue CB1 mRNA levels along with other adipogenesis-related genes in rat models of diet-induced obesity
| العنوان: | Tart cherry (Prunus cerasus L.) dietary supplement modulates visceral adipose tissue CB1 mRNA levels along with other adipogenesis-related genes in rat models of diet-induced obesity |
|---|---|
| المؤلفون: | Paolo Cocci, Michele Moruzzi, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Consuelo Amantini, Giulio Lupidi, Seyed Khosrow Tayebati, Daniele Tomassoni, Ilenia Martinelli, Federica Maggi, Francesco Alessandro Palermo, Silvia Damiano, Gilberto Mosconi |
| المصدر: | European journal of nutrition. 60(5) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, TRPV1, Medicine (miscellaneous), Adipose tissue, 030209 endocrinology & metabolism, Intra-Abdominal Fat, Prunus avium, Diet, High-Fat, 03 medical and health sciences, 0302 clinical medicine, Fatty acid amide hydrolase, Internal medicine, medicine, Animals, Obesity, RNA, Messenger, 030109 nutrition & dietetics, Nutrition and Dietetics, Adipogenesis, Adiponectin, biology, Leptin, food and beverages, biology.organism_classification, Endocannabinoid system, Prunus cerasus, Rats, Endocrinology, Adipose Tissue, Dietary Supplements, lipids (amino acids, peptides, and proteins) |
| الوصف: | There is increasing evidence for the involvement of dietary bioactive compounds in the cross-talk modulation of endocannabinoid system and some of the key regulators of transcriptional control for adipogenesis. We aimed to characterize the expression of cannabinoid CB1/CB2 receptors and fatty acid amide hydrolase (FAAH) along with selected adipogenesis-related genes (PPARγ, SREBP-1c and PREF-1), adipocyte-secreted factors (leptin and adiponectin), mitochondrial bioenergetic modulators (PGC-1A and UCP-2), and transient receptor potential vanilloid subtype 1 (TRPV1) and 2 (TRPV2) channels in visceral adipose tissue of rats fed with a high-fat diet (HFD) containing either tart cherry seeds alone or tart cherry seeds and juice for 17 weeks. The visceral adipose tissue was weighed and checked the expression of different markers by qRT-PCR, Western blot and immunohistochemistry. Tart cherry supplements were able to downregulate the HFD-induced mRNA expression of CB1 receptor, SREBP-1c, PPARγ, leptin, TRPV1 and TRPV2 resulting in potential anti-adipogenic effects. The present study points out that the intake of bioactive constituents of tart cherry may attenuate the effect of adipogenesis by acting directly on the adipose tissue and modulating the interplay between CB1, PPARγ and TRPV channel gene transcription. |
| تدمد: | 1436-6215 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91b23ac469ec4ee9e92e2a988122774Test https://pubmed.ncbi.nlm.nih.gov/33386893Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d91b23ac469ec4ee9e92e2a988122774 |
| قاعدة البيانات: | OpenAIRE |
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