ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1
العنوان: | ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1 |
---|---|
المؤلفون: | Daoguang Yan, Yu Huang, Wenbin Zhong, Xiuye Cao, Guoping Pan, Meng-Yang Xu, Qun Niu, Qing Yi, Xiaoqin Feng, Mingchuan Li |
المصدر: | Blood. 139:1052-1065 |
بيانات النشر: | American Society of Hematology, 2022. |
سنة النشر: | 2022 |
مصطلحات موضوعية: | Receptors, Steroid, Carcinogenesis, T-Lymphocytes, T cell, Immunology, Apoptosis, Biochemistry, Virus, Mice, hemic and lymphatic diseases, Tumor Cells, Cultured, medicine, Pi, Animals, Humans, Leukemia-Lymphoma, Adult T-Cell, Protein kinase B, Cell Proliferation, Human T-lymphotropic virus 1, Hyperactivation, Gene Expression Regulation, Leukemic, Chemistry, Mechanism (biology), Gene Products, tax, Cell Biology, Hematology, Prognosis, medicine.disease, HTLV-I Infections, Xenograft Model Antitumor Assays, Human T cell leukemia virus, Leukemia, medicine.anatomical_structure, Cancer research |
الوصف: | Human T-cell leukemia virus 1 (HTLV-1) causes adult T-cell leukemia (ATL), but the mechanism underlying its initiation remains elusive. In this study, ORP4L was expressed in ATL cells but not in normal T-cells. ORP4L ablation completely blocked T-cell leukemogenesis induced by the HTLV-1 oncoprotein Tax in mice, whereas engineering ORP4L expression in T-cells resulted in T-cell leukemia in mice, suggesting the oncogenic properties and prerequisite of ORP4L promote the initiation of T-cell leukemogenesis. For molecular insight, we found that loss of miR-31 caused by HTLV-1 induced ORP4L expression in T-cells. ORP4L interacts with PI3Kδ to promote PI(3,4,5)P3 generation, contributing to AKT hyperactivation; NF-κB–dependent, p53 inactivation-induced pro-oncogene expression; and T-cell leukemogenesis. Consistently, ORP4L ablation eliminates human ATL cells in patient-derived xenograft ATL models. These results reveal a plausible mechanism of T-cell deterioration by HTLV-1 that can be therapeutically targeted. |
تدمد: | 1528-0020 0006-4971 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51da57051e6de7c93638950da36898fTest https://doi.org/10.1182/blood.2021013579Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....d51da57051e6de7c93638950da36898f |
قاعدة البيانات: | OpenAIRE |
ResultId |
1 |
---|---|
Header |
edsair OpenAIRE edsair.doi.dedup.....d51da57051e6de7c93638950da36898f 905 3 unknown 905.362609863281 |
PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi.dedup.....d51da57051e6de7c93638950da36898f&custid=s6537998&authtype=sso |
FullText |
Array
(
[Availability] => 0
)
|
Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Daoguang+Yan%22">Daoguang Yan</searchLink><br /><searchLink fieldCode="AR" term="%22Yu+Huang%22">Yu Huang</searchLink><br /><searchLink fieldCode="AR" term="%22Wenbin+Zhong%22">Wenbin Zhong</searchLink><br /><searchLink fieldCode="AR" term="%22Xiuye+Cao%22">Xiuye Cao</searchLink><br /><searchLink fieldCode="AR" term="%22Guoping+Pan%22">Guoping Pan</searchLink><br /><searchLink fieldCode="AR" term="%22Meng-Yang+Xu%22">Meng-Yang Xu</searchLink><br /><searchLink fieldCode="AR" term="%22Qun+Niu%22">Qun Niu</searchLink><br /><searchLink fieldCode="AR" term="%22Qing+Yi%22">Qing Yi</searchLink><br /><searchLink fieldCode="AR" term="%22Xiaoqin+Feng%22">Xiaoqin Feng</searchLink><br /><searchLink fieldCode="AR" term="%22Mingchuan+Li%22">Mingchuan Li</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => <i>Blood</i>. 139:1052-1065 ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => American Society of Hematology, 2022. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2022 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Receptors%2C+Steroid%22">Receptors, Steroid</searchLink><br /><searchLink fieldCode="DE" term="%22Carcinogenesis%22">Carcinogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22T-Lymphocytes%22">T-Lymphocytes</searchLink><br /><searchLink fieldCode="DE" term="%22T+cell%22">T cell</searchLink><br /><searchLink fieldCode="DE" term="%22Immunology%22">Immunology</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis%22">Apoptosis</searchLink><br /><searchLink fieldCode="DE" term="%22Biochemistry%22">Biochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Virus%22">Virus</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink><br /><searchLink fieldCode="DE" term="%22hemic+and+lymphatic+diseases%22">hemic and lymphatic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+Cells%2C+Cultured%22">Tumor Cells, Cultured</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%22">medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Pi%22">Pi</searchLink><br /><searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Leukemia-Lymphoma%2C+Adult+T-Cell%22">Leukemia-Lymphoma, Adult T-Cell</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+kinase+B%22">Protein kinase B</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+Proliferation%22">Cell Proliferation</searchLink><br /><searchLink fieldCode="DE" term="%22Human+T-lymphotropic+virus+1%22">Human T-lymphotropic virus 1</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperactivation%22">Hyperactivation</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+Expression+Regulation%2C+Leukemic%22">Gene Expression Regulation, Leukemic</searchLink><br /><searchLink fieldCode="DE" term="%22Chemistry%22">Chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Mechanism+%28biology%29%22">Mechanism (biology)</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+Products%2C+tax%22">Gene Products, tax</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+Biology%22">Cell Biology</searchLink><br /><searchLink fieldCode="DE" term="%22Hematology%22">Hematology</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Edisease%22">medicine.disease</searchLink><br /><searchLink fieldCode="DE" term="%22HTLV-I+Infections%22">HTLV-I Infections</searchLink><br /><searchLink fieldCode="DE" term="%22Xenograft+Model+Antitumor+Assays%22">Xenograft Model Antitumor Assays</searchLink><br /><searchLink fieldCode="DE" term="%22Human+T+cell+leukemia+virus%22">Human T cell leukemia virus</searchLink><br /><searchLink fieldCode="DE" term="%22Leukemia%22">Leukemia</searchLink><br /><searchLink fieldCode="DE" term="%22medicine%2Eanatomical%5Fstructure%22">medicine.anatomical_structure</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+research%22">Cancer research</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Human T-cell leukemia virus 1 (HTLV-1) causes adult T-cell leukemia (ATL), but the mechanism underlying its initiation remains elusive. In this study, ORP4L was expressed in ATL cells but not in normal T-cells. ORP4L ablation completely blocked T-cell leukemogenesis induced by the HTLV-1 oncoprotein Tax in mice, whereas engineering ORP4L expression in T-cells resulted in T-cell leukemia in mice, suggesting the oncogenic properties and prerequisite of ORP4L promote the initiation of T-cell leukemogenesis. For molecular insight, we found that loss of miR-31 caused by HTLV-1 induced ORP4L expression in T-cells. ORP4L interacts with PI3Kδ to promote PI(3,4,5)P3 generation, contributing to AKT hyperactivation; NF-κB–dependent, p53 inactivation-induced pro-oncogene expression; and T-cell leukemogenesis. Consistently, ORP4L ablation eliminates human ATL cells in patient-derived xenograft ATL models. These results reveal a plausible mechanism of T-cell deterioration by HTLV-1 that can be therapeutically targeted. ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1528-0020<br />0006-4971 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51da57051e6de7c93638950da36898f" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51da57051e6de7c93638950da36898f</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1182/blood.2021013579" linkWindow="_blank">https://doi.org/10.1182/blood.2021013579</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => OPEN ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi.dedup.....d51da57051e6de7c93638950da36898f ) |
RecordInfo |
Array
(
[BibEntity] => Array
(
[Languages] => Array
(
[0] => Array
(
[Text] => Undetermined
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 14
[StartPage] => 1052
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => Receptors, Steroid
[Type] => general
)
[1] => Array
(
[SubjectFull] => Carcinogenesis
[Type] => general
)
[2] => Array
(
[SubjectFull] => T-Lymphocytes
[Type] => general
)
[3] => Array
(
[SubjectFull] => T cell
[Type] => general
)
[4] => Array
(
[SubjectFull] => Immunology
[Type] => general
)
[5] => Array
(
[SubjectFull] => Apoptosis
[Type] => general
)
[6] => Array
(
[SubjectFull] => Biochemistry
[Type] => general
)
[7] => Array
(
[SubjectFull] => Virus
[Type] => general
)
[8] => Array
(
[SubjectFull] => Mice
[Type] => general
)
[9] => Array
(
[SubjectFull] => hemic and lymphatic diseases
[Type] => general
)
[10] => Array
(
[SubjectFull] => Tumor Cells, Cultured
[Type] => general
)
[11] => Array
(
[SubjectFull] => medicine
[Type] => general
)
[12] => Array
(
[SubjectFull] => Pi
[Type] => general
)
[13] => Array
(
[SubjectFull] => Animals
[Type] => general
)
[14] => Array
(
[SubjectFull] => Humans
[Type] => general
)
[15] => Array
(
[SubjectFull] => Leukemia-Lymphoma, Adult T-Cell
[Type] => general
)
[16] => Array
(
[SubjectFull] => Protein kinase B
[Type] => general
)
[17] => Array
(
[SubjectFull] => Cell Proliferation
[Type] => general
)
[18] => Array
(
[SubjectFull] => Human T-lymphotropic virus 1
[Type] => general
)
[19] => Array
(
[SubjectFull] => Hyperactivation
[Type] => general
)
[20] => Array
(
[SubjectFull] => Gene Expression Regulation, Leukemic
[Type] => general
)
[21] => Array
(
[SubjectFull] => Chemistry
[Type] => general
)
[22] => Array
(
[SubjectFull] => Mechanism (biology)
[Type] => general
)
[23] => Array
(
[SubjectFull] => Gene Products, tax
[Type] => general
)
[24] => Array
(
[SubjectFull] => Cell Biology
[Type] => general
)
[25] => Array
(
[SubjectFull] => Hematology
[Type] => general
)
[26] => Array
(
[SubjectFull] => Prognosis
[Type] => general
)
[27] => Array
(
[SubjectFull] => medicine.disease
[Type] => general
)
[28] => Array
(
[SubjectFull] => HTLV-I Infections
[Type] => general
)
[29] => Array
(
[SubjectFull] => Xenograft Model Antitumor Assays
[Type] => general
)
[30] => Array
(
[SubjectFull] => Human T cell leukemia virus
[Type] => general
)
[31] => Array
(
[SubjectFull] => Leukemia
[Type] => general
)
[32] => Array
(
[SubjectFull] => medicine.anatomical_structure
[Type] => general
)
[33] => Array
(
[SubjectFull] => Cancer research
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Daoguang Yan
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Yu Huang
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Wenbin Zhong
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Xiuye Cao
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Guoping Pan
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Meng-Yang Xu
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Qun Niu
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Qing Yi
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Xiaoqin Feng
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Mingchuan Li
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 17
[M] => 02
[Type] => published
[Y] => 2022
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 15280020
)
[1] => Array
(
[Type] => issn-print
[Value] => 00064971
)
[2] => Array
(
[Type] => issn-locals
[Value] => edsair
)
[3] => Array
(
[Type] => issn-locals
[Value] => edsairFT
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 139
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Blood
[Type] => main
)
)
)
)
)
)
)
|
IllustrationInfo |