Persistent level of mental distress in PTSD patients is not reflected in cytokine levels 1 year after the treatment
العنوان: | Persistent level of mental distress in PTSD patients is not reflected in cytokine levels 1 year after the treatment |
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المؤلفون: | Helge Prytz Toft, Terje Tilden, Jørgen G. Bramness, Ingeborg Bolstad, Lars Lien |
المصدر: | Acta Neuropsychiatrica |
بيانات النشر: | Cambridge University Press, 2021. |
سنة النشر: | 2021 |
مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Interleukin-1beta, Anxiety, behavioral disciplines and activities, Severity of Illness Index, Feeding and Eating Disorders, Stress Disorders, Post-Traumatic, 03 medical and health sciences, Mental distress, 0302 clinical medicine, Internal medicine, mental disorders, medicine, Humans, VDP::Medisinske Fag: 700, Biological Psychiatry, Depression (differential diagnoses), Inflammation, Psychiatric Status Rating Scales, Inpatients, business.industry, Depression, Norway, Tumor Necrosis Factor-alpha, After discharge, Middle Aged, Serum samples, 030227 psychiatry, Interleukin 1β, VDP::Medical disciplines: 700, Psychiatry and Mental health, Interleukin 1 Receptor Antagonist Protein, Cytokine, Case-Control Studies, Cytokines, Female, medicine.symptom, business, 030217 neurology & neurosurgery, Follow-Up Studies |
الوصف: | Objective:Cross-sectional data show that post-traumatic stress disorder (PTSD) patients often have increased levels of circulating inflammatory markers. There is, however, still a paucity of longitudinal studies with long follow-up times on levels of cytokines in such patients. The current study assesses patients with and without PTSD diagnosis 1 year after discharge from inpatient treatment.Methods:Patients in treatment for serious non-psychotic mental disorders were recruited at the beginning of their treatment stay at a psychiatric centre in Norway. Ninety patients submitted serum samples and filled out the Hopkins Symptom Checklist-90 Revised Global Severity Index (HSCL-90R GSI) questionnaire during their mainstay and at a follow-up stay 1 year after discharge. Of these patients, 33 were diagnosed with PTSD, 48 with anxiety, depression, or eating disorder, while 9 patients had missing data. The patients were diagnosed using the Mini-International Neuropsychiatric Interview (MINI).Results:At the follow-up stay (T3), PTSD patients had higher levels of GSI scores than non-PTSD patients (p = 0.048). These levels were unchanged from the year before (T2) in both groups. The levels of circulating cytokines/chemokine did not differ between the PTSD and non-PTSD patients at T3. At T2, however, the PTSD and non-PTSD groups exhibited different levels of interleukin 1β (IL-1β) (p = 0.053), IL-1RA (p = 0.042), and TNF-α (p = 0.037), with the PTSD patients having the higher levels.Conclusion:Despite exhibiting different mental distress scores, the PTSD and non-PTSD patients did not differ regarding levels of circulating inflammatory markers at 1-year follow-up. |
وصف الملف: | application/pdf |
اللغة: | English |
تدمد: | 0924-2708 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f475eabb8b0a0abfcaa7913d558c99Test https://hdl.handle.net/10037/21876Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....d0f475eabb8b0a0abfcaa7913d558c99 |
قاعدة البيانات: | OpenAIRE |