Ciliary Neurotrophic Factor (CNTF) Induces Serum Amyloid A, Hypoglycaemia and Anorexia, and Potentiates IL-1 Induced Corticosterone and IL-6 Production in Mice
العنوان: | Ciliary Neurotrophic Factor (CNTF) Induces Serum Amyloid A, Hypoglycaemia and Anorexia, and Potentiates IL-1 Induced Corticosterone and IL-6 Production in Mice |
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المؤلفون: | Leland Shapiro, Jean D. Sipe, Lavinia Cantoni, Maria Carelli, Pietro Ghezzi, Mario Conni, Fabio Benigni, Marina Sironi, Giamila Fantuzzi, Charles A. Dinarello |
المصدر: | Cytokine. 7:150-156 |
بيانات النشر: | Elsevier BV, 1995. |
سنة النشر: | 1995 |
مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, Time Factors, Cell Survival, Immunology, Mice, Inbred Strains, Nerve Tissue Proteins, Chick Embryo, Anorexia, Biology, Ciliary neurotrophic factor, Biochemistry, Mice, chemistry.chemical_compound, Transduction (genetics), Corticosterone, Internal medicine, medicine, Animals, Humans, Immunology and Allergy, Ciliary Neurotrophic Factor, Nerve Growth Factors, Serum amyloid A, Interleukin 6, Molecular Biology, Neurons, Serum Amyloid A Protein, Interleukin-6, Body Weight, Ciliary ganglion, Drug Synergism, Drug Tolerance, Feeding Behavior, Hematology, Glycoprotein 130, Hypoglycemia, Recombinant Proteins, Endocrinology, chemistry, biology.protein, Biological Assay, medicine.symptom, Interleukin-1 |
الوصف: | Ciliary neurotrophic factor (CNTF) supports the survival of ciliary ganglion neurons and was shown to induce the synthesis of acute-phase proteins and fever. We studied the effect of CNTF, alone or in association with IL-1, on levels of corticosterone (CS), glucose, serum amyloid A (SAA), and IL-6. We also compared the effect of CNTF with that of IL-6, since the gp130 receptor subunit for CNTF is shared with that of IL-6. A single intravenous injection of CNTF induced hypoglycaemia and SAA and potentiated IL-1-induced CS and IL-6. Chronic CNTF, but not IL-6, resulted in decreased food intake and body weight up to days 6-7. After this time, body weight and food intake recovered even if CNTF treatment was continued, indicating that a phenomenon of tolerance occurred. Finally, CNTF (unlike IL-1) was not toxic in adrenalectomized mice. Therefore the similarities of CNTF activities with those of other cytokines, particularly IL-6, might go beyond the activation of the same receptor-signal transduction pathway of IL-6. |
تدمد: | 1043-4666 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bca3e010d763f027e8f9ebced38827Test https://doi.org/10.1006/cyto.1995.1020Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....c8bca3e010d763f027e8f9ebced38827 |
قاعدة البيانات: | OpenAIRE |
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