Diabetes mellitus impairs circulating proangiogenic granulocytes
العنوان: | Diabetes mellitus impairs circulating proangiogenic granulocytes |
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المؤلفون: | Marianna D’Anna, Benedetta Maria Bonora, Lisa Menegazzo, Mattia Albiero, Angelo Avogaro, Roberta Cappellari, Gian Paolo Fadini |
المصدر: | Diabetologia. 63(9) |
سنة النشر: | 2019 |
مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, medicine.medical_specialty, Angiogenesis, Neutrophils, Endocrinology, Diabetes and Metabolism, Integrin alpha4, Neovascularization, Physiologic, 030209 endocrinology & metabolism, CD49d, Diabetes Mellitus, Experimental, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Antigen, Diabetes mellitus, Internal medicine, Internal Medicine, Medicine, Animals, Humans, Dapagliflozin, Aged, Type 1 diabetes, business.industry, Endothelial Cells, Middle Aged, medicine.disease, In vitro, Endothelial stem cell, Eosinophils, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 1, nervous system, chemistry, Diabetes Mellitus, Type 2, Case-Control Studies, Female, business, Granulocytes |
الوصف: | Cardiovascular risk in diabetes is at least in part attributable to defective angiogenesis. Since diabetes negatively affects blood cells involved in angiogenesis, we herein evaluated whether diabetes impairs proangiogenic granulocytes (PAGs). We characterised and quantified PAGs as CD49d+ granulocytes in peripheral blood of participants with type 2 or type 1 diabetes and in non-diabetic control participants. We evaluated PAG antigenic profile and assessed in vitro functional properties of CD49d+ granulocytes using 2D and 3D angiogenesis assays. We also quantified PAGs before and after glucose control with a sodium–glucose cotransporter 2 (SGLT2) inhibitor, dapagliflozin. In parallel, we measured Ly6G+CD49d+ PAGs in streptozotocin-induced type 1-like diabetic mice vs non-diabetic control mice. PAGs were composed of eosinophils (>80%) and neutrophils ( |
تدمد: | 1432-0428 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48cf0be8eab338ed2ba9c4b08696d66Test https://pubmed.ncbi.nlm.nih.gov/32306097Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....c48cf0be8eab338ed2ba9c4b08696d66 |
قاعدة البيانات: | OpenAIRE |
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